Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0034063 (pulmonary edema)
 10,665 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Despite the technical advances made during the last several years, chronic dialysis still is plagued by continuing problems. Intermittent volume overload is one of the most common. The radiologic evidence of pulmonary edema can be confusing in the end-stage renal disease population. The following case illustrates a hemodialysis patient with pulmonary edema whose initial chest x-ray appeared more consistent with metastatic malignancy.
 ...
PMID:Unusual presentation of pulmonary edema in a hemodialysis patient. 259 59

Hysteroscopy provides a means of accurately diagnosing and treating most forms of abnormal uterine bleeding. Submucous myomas and endometrial polyps may be easily removed with the resectoscope. If the myomas are large, pre-treatment with GnRH agonists will shrink the tumours, and facilitate hysteroscopic removal. One third of patients undergoing hysteroscopic myomectomy will have recurrent symptoms that require intervention. In the absence of malignancy, and in patients not desiring fertility, persistent dysfunctional uterine bleeding may be treated by endometrial ablation. These patients should be pre-treated with either danazol or GnRH agonists. Success with these techniques approaches 85%, but information about the long-term outcome for the majority of the reported cases is not available. Complications include uterine perforation and damage of intra-abdominal structures, fluid and electrolyte imbalance including pulmonary oedema, and anaphylactic reactions to certain distention media (32% dextran 70). These procedures provide the gynaecologist with an effective means of treating abnormal uterine bleeding without the attendant morbidity of a hysterectomy.
 ...
PMID:Hysteroscopic management of uterine bleeding. 269 28

Seventy-two adult patients with previously untreated acute myeloid leukemia received the CHA regimen as induction chemotherapy: CCNU 80 mg/m2 on day 1, Adriamycin 35 mg/m2 i.v. on days 1, 2 and 3, and continuous infusion of cytarabine 100 mg/m2/24 h from day 1 to 10. Forty-nine patients (68%) presented at least one of the following symptoms: acral erythema with dysesthesias in the palms and/or soles (39%); cholestatic hepatitis (39%); profuse sterile diarrhea associated with abdominal distention (33%); acute cerebellar dysfunction (32%) and non-cardiogenic pulmonary edema (21%). Most of these toxic symptoms appeared 8-20 days after the first dose. As these clinical features were absent or exceptional in patients treated with another regimen within a controlled trial, they are reported as toxic-side-effects of the chemotherapy regimen. Acral erythema was found to be predictive of complete remission (P less than 0.01, odds ratio: 6.33); neurotoxicity was prognostic for death in aplasia (P less than 0.05); the absence of any of the five symptoms was associated with failure of the induction regimen (P less than 0.02).
Eur J Cancer Clin Oncol 1989 Aug
PMID:Acral erythema and systemic toxicity related to CHA induction therapy in acute myeloid leukemia. 276 7

Recombinant interleukin 2 (rIL-2) administration, a new form of therapy for patients with far-advanced cancer, is associated with a "third space" syndrome, i.e., pulmonary edema, respiratory distress, and hypoxemia, which limits the dose and duration of treatment. To extend our knowledge regarding this toxicity, we established a sheep chronic lung lymph fistula model and measured hemodynamics, arterial blood gases, caudal mediastinal (lung) lymph flow (QL), and blood and lung lymph cellular changes before, during, and after (recovery) a 3-day continuous rIL-2 infusion (9 x 10(5) U/kg). Moderate systemic hypotension, mild pulmonary hypertension, and an increase in alveolar-arterial PO2 gradient was present on day 3 of rIL-2 infusion. QL increased from a base line of 1.9 +/- 0.2 to a maximum of 4.3 +/- 1.1 ml/15 min on day 3 of rIL-2 infusion. At no time was there a change in lymph-to-plasma protein ratio. The leukocyte count increased significantly to 16.1 +/- 4.5 x 10(3) cells/mm3 at recovery day 1. The percentage of blood lymphocytes decreased significantly by day 1 of rIL-2 infusion, returned to base-line levels on day 3, and significantly increased on day 2 of recovery. Lung lymph lymphocytes decreased significantly on days 1 and 2 of rIL-2 infusion. There was a shift in their size; i.e., their area increased from 32 +/- 7 to 57 +/- 19 micron 2 (P less than 0.05) by day 2 of rIL-2 infusion. By day 1 of recovery, lung lymph lymphocyte counts increased significantly.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Cardiorespiratory and cellular changes with interleukin 2 infusion in sheep. 278 28

Adoptive immunotherapy, the administration of interleukin-2 (IL-2) and interleukin-2 activated cells, leads to tumor regression in some patients with advanced cancer. Although this new therapeutic modality offers hope for the future, at present, a multitude of toxicities limit the total dose and duration of therapy. Among the toxic side effects a purported third space or vascular leak syndrome is the most serious. In this review, we detail the evidence for a third space syndrome (peripheral edema, ascites, oliguria, elevated serum creatinine levels) and cardiopulmonary dysfunction (hypotension, respiratory distress, pulmonary edema, hypoxemia) with adoptive immunotherapy in human and animal studies. We conclude that IL-2 administration is associated with increased pulmonary microvascular permeability, infiltration of the lung parenchyma with large esterase negative lymphoid cells, hypoxemia, systemic hypotension, positive fluid balance and, in animals, transient pulmonary hypertension. These abnormalities do not seem to be caused by IL-2 directly; the causes may be mediated by IL-2 activated lymphocytes or other IL-2 activated cellular mediators.
 ...
PMID:Cardiopulmonary toxicity of adoptive immunotherapy. 306 15

A new approach to cancer treatment has been developed based on the adoptive transfer of activated lymphocytes into cancer patients. Lymphocytes harvested from patients by leukapheresis are converted into lymphokine-activated killer (LAK) cells by incubation with recombinant interleukin-2 (rIL-2). These LAK cells are then infused back into the patients in combination with intravenous IL-2. Among 25 patients treated with this form of adoptive immunotherapy there were 11 patients with measurable tumor reductions, including 1 complete responder. The majority of responses occurred in patients with metastatic renal cell carcinoma, melanoma and colorectal carcinoma. The toxicities of IL-2, including fluid retention and pulmonary edema, limit therapy, and laboratory investigation is now aimed toward understanding the mechanism of IL-2 toxicity. The use of LAK cells and IL-2 in cancer therapy is still in a developmental stage and needs to be refined before its role can be definitely established.
 ...
PMID:Therapy of cancer using the adoptive transfer of activated killer cells and interleukin-2. 312 51

Systemic hyperthermia is an adjuvant method of treatment used in the management of advanced cancer; the hyperthermic state is induced by either the thermal blanket or the external blood shunt method. Strict monitoring of the cardiopulmonary status, the temperature, and the fluid balance is necessary. Chest radiographs were reviewed of 61 patients undergoing hyperthermia; pre-, intra-, and posthyperthermia radiographs were compared and significant radiographic findings tabulated. Intra- and postprocedural pulmonary edema, cardiomegaly, and pleural effusions were found in a significant number of patients. The radiologist should be familiar with systemic hyperthermia as a treatment modality for metastatic cancer and with the chest radiographic alterations resulting from it.
 ...
PMID:Thoracic radiographic changes after systemic hyperthermia for advanced cancer. 315 80

Adoptive immunotherapy is a new promising treatment for cancer but is associated with severe toxicity mainly related to a capillary leak syndrome. We report the case of a patient with metastatic hypernephroma, who had many complications such as coma, renal failure, pulmonary edema, life-threatening acidosis, cardiac arrhythmias and venous thrombosis. Critical care specialists should be aware of this type of cancer therapy because of multiple side effects requiring ICU supportive care.
 ...
PMID:Multiple organ failure during interleukin-2 administration and LAK cells infusion. 326 5

Based on a study of the literature and our own experience treating fisherman poisoned by mustard gas, this article outlines the clinical effects, and toxicological and mutagenic properties of the agent. Mustards are very persistent chemical agents that easily penetrate clothing. Mustard gas usually causes clinical symptoms after the liquid penetrates the skin or the vapor is inhaled. Skin lesions are similar to first- or second-degree burns and usually heal spontaneously in 4 to 6 weeks. Eye symptoms are photophobia and reduced vision. Following inhalation of the agent, pulmonary edema and long-term dyspnea may be seen. As mustard gas is an alkylating substance, it is conceivable that the risk of developing cancer may be increased, as observed in people who were involved with the production of mustard gas and in animals exposed to the gas. Also, transient significantly increased sister chromatid exchange rates have been found in fishermen exposed to mustard gas. Patients exposed to mustard gas must be treated immediately after exposure. Treatment should consist of cleaning of the exposed skin and clothes with an antigas powder and water and soap. The skin lesions should be treated as burns. Eye lesions and respiratory problems should be treated symptomatically.
 ...
PMID:Mustard gas: clinical, toxicological, and mutagenic aspects based on modern experience. 331 37

A study of 30 cases of pheochromocytoma encountered at our department between 1959 and 1986 is presented. Fourteen patients were males and 16 were females. Their ages ranged from 18 to 72 years with a peak incidence in the fifties. Hypertension was present in 87% of the patients. The incidence of extra-adrenal tumors was 30% and that of malignancy 7%. The 24-hr urinary level of catecholamine was to a certain degree in accord with the location of the tumor and type of hypertension. Computed tomography and venous sampling were very useful for the diagnosis which had an accuracy rate of 100% in this series. Preoperative management using an alpha-blocker was effective in controlling blood pressure and circulating blood volume in most cases. Postoperative blood pressure was normalized within a week after operation in 85% of the patients who had been suffering from hypertension, although elevated levels of norepinephrine in urine were still noted in 56% of the patients one week after operation. Of the 27 follow-up cases, 21 cases (78%) were in good health and 2 cases were alive with hypertension with a mean follow-up period of 8.1 years. Four patients died, one during angiography, one of pulmonary edema one day after operation and the other 2 of metastases of malignant pheochromocytoma.
 ...
PMID:[A clinical review of 30 pheochromocytoma patients]. 340 May 41


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>