Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0033774 (pruritus)
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Human Gene/Protein
prion protein precursor 11.1
ANKRD13B 11.1
B1F3 11.1
HECT domain containing 3 11.1
ENTPD3 protein 11.1
ANKRD13D 11.1
ANKRD13A 11.1
Itch 11.1
MRGPRX1 10.4
MRGPRX4 10.1
CCDC47 10.1
Kallikrein 5 9.8
IL-31 9.6
ARRDC1 9.5
USP53 9.5
TDRD10 9.5
GGT 2 9.1
LIG-1 9.1
MRGPRD 9.1
Neuromedin B receptor 9.1
TRPV3 protein 8.8
CFEOM2 8.8
CD39L3 8.8
HECW1 8.8
TrpV3 8.8
MRGPRX2 8.7
RNF11 8.5
ENTPD3 8.5
SREB3 8.5
constitutive photomorphogenic protein 8.5
intelectin 2 8.5
APC7 8.5
NDFIP2 8.5
oncostatin M receptor 8.5
histamine H4 receptor 8.5
NEDL1 8.4
ABCB4 protein 8.3
TAFA4 8.3
Prepronociceptin 8.3
GRPR 8.1
TMEM79 8.1
AIP2 8.1
Histamine H4 receptor 8.1
opioid receptor mu 8.0
WW domain containing E3 ubiquitin protein ligase 1 8.0
PFIC 8.0
TPSAB1 8.0
TPSB2 7.9
Vanilloid receptor subtype 1 7.9
GRAIL 7.9
ARRDC4 7.9
TAX1BP1 7.9
gastrin-releasing peptide receptor 7.9
AIF4 7.8
ABCB11 7.8
WWP1 7.8
Syntaxin 8 7.8
50 AA 7.8
ileal bile acid transporter 7.7
dermokine 7.7
OSMR 7.7
Cytochrome c oxidase subunit 1 7.6
RNF183 7.6
BHLHB5 7.6
NPP6 7.6
PCDH12 7.6
SLC10A4 7.6
FLG2 7.6
ABCB4 7.5
gamma adaptin 7.5
Fc-epsilon receptor 7.5
proteinase-activated receptor-2 7.5
ITCH 7.5
multidrug resistance protein 3 7.5
TJP2 7.5
WWP2 7.4
Gemin8 7.4
frizzled 4 7.4
neuropeptide Y receptor Y1 7.4
Alagille syndrome 7.4
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Disease
Subacute myelomonocytic leukemia 11.1
Cutaneous onchocerciasis 11.1
Harara 11.1
pruritus 11.1
Diffuse dermatitis 11.1
Subacute prurigo 11.1
anemia; progressive 11.1
Apocrine nevus 11.1
parasitic eye infection 11.1
High turnover osteopathy 11.1
Erythema gyratum 11.1
vagabond's disease 11.1
Hyaluronidase allergy 11.1
Mixed ductal-endocrine carcinoma 11.1
Alopecia, drug 11.1
Itch mite infestation 11.1
Itching purpura 11.1
Pruritus senilis 11.1
copra itch 11.1
Infestation by land leeches 11.1
Aquagenic pruritus 11.0
psychogenic pruritus 10.8
Epidermolysis bullosa pruriginosa 10.7
Chronic prurigo 10.5
Benign recurrent intrahepatic cholestasis 10.2
Compulsive skin picking 10.1
Chronic allergic conjunctivitis 10.1
Eczematid-like purpura of Doucas and Kapetanakis 10.1
Facial seborrheic dermatitis 10.1
Thrombosed haemorrhoids 10.1
parasitic skin disorder 10.1
Acute diffuse otitis externa 10.1
craw-craw 10.1
Childhood lichen sclerosus 10.1
Anogenital lichen sclerosus 10.1
Plane xanthoma 10.1
Seasonal allergic conjunctivitis 10.1
Autoimmune urticaria 10.1
parasitophobia 10.1
Generalized eruptive keratoacanthoma 10.1
Skin and subcutaneous tissue disorders 10.1
Acquired reactive perforating dermatosis 10.1
erythematosquamous dermatosis 10.1
Perianal Bowen's disease 10.1
Prurigo nodularis 9.9
Rhus dermatitis 9.8
Trombiculiasis 9.8
Aquagenic urticaria 9.8
Chronic dermatitis 9.8
lichen simplex chronicus 9.6
Asteatosis 9.5
Allergy to wheat 9.5
Chronic autoimmune urticaria 9.5
swimmer's ear 9.5
Leopard skin 9.5
Paraneoplastic dermatomyositis 9.5
Yeast infection 9.5
Notoedric mange 9.5
Cheyletiella dermatitis 9.5
Ureaplasma urethritis 9.5
dipetalonemiasis 9.5
eczematid 9.5
phthiriasis 9.5
prurigo 9.5
PFIC1 9.5
PFIC3 9.4
Reactive perforating collagenosis 9.4
Dandruff 9.4
Eosinophilic folliculitis 9.1
Viral rhinitis 9.1
Mal seco 9.1
Acral lick dermatitis 9.1
Caterpillar dermatitis 9.1
Pruritic folliculitis of pregnancy 9.1
Xerosis cutis 9.1
Suppurative cholangitis 9.1
Pruritic urticarial papules and plaques of pregnancy 9.0
Exercise-induced anaphylaxis 9.0
Mazzotti reaction 9.0
xerosis 9.0
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Symptom
Anal irritation 11.1
Pruritus scroti 11.1
Drug-induced pruritus 11.1
Vesical tenesmus 11.1
Vulvovaginal pruritus 11.1
Tongue symptoms 11.1
Oral pruritus 11.1
Ear pruritus 11.1
Anogenital pruritus 11.1
Cholestatic pruritus 11.1
Scalp pruritus 10.7
Generalized pruritus 10.7
Pruritus of pregnancy 10.5
Pruritus vulvae 10.5
General symptoms and signs 10.1
Cholinergic pruritus 10.1
Vulvovaginal pain 10.1
vaginal discomfort 10.0
redness of the eyes 9.3
Juvenile spring eruption 9.3
Vulval pain 9.1
Anal symptoms 9.1
Intermittent diarrhea 9.1
skin tenderness 9.1
Darier's sign 8.9
sneezing 8.9
skin pain 8.8
runny eyes 8.8
Sharp pain 8.8
symptom or complaint 8.8
Auspitz's sign 8.8
prickling sensation 8.8
dry skin 8.7
Skin symptoms 8.6
inflammation of the vulva 8.5
Upper back pain 8.5
Postoperative nausea 8.5
vulval irritation 8.3
nasal congestion 8.1
Breast tenderness 8.0
enanthema 8.0
rhinorrhea 7.9
Vulvodynia 7.8
Purulent discharge 7.8
Incisional pain 7.8
glossopyrosis 7.8
Perineal pain 7.8
Burning mouth 7.8
Nasal symptoms 7.7
gastrointestinal colic 7.6
Urticarial vasculitis 7.6
localized rash 7.6
vaginal itching 7.6
scaly skin 7.6
generalized erythema 7.5
burning on urination 7.5
Visual discomfort 7.5
erythema 7.5
stuffy nose 7.5
feeling nervous 7.5
tingling 7.4
Pitting edema 7.4
throat irritation 7.4
dark urine 7.3
eye discharge 7.3
dry throat 7.3
Hyposensitivity 7.3
vestibulitis 7.2
Neurogenic pain 7.2
penile discharge 7.2
itchy nose 7.1
Crawling 7.1
anal pain 7.0
Vaginal dryness 6.9
disturbance of sensation 6.9
Local reaction 6.9
axillary pain 6.9
glossodynia 6.9
GI pain 6.8
Burning pain 6.8
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Drug
Naphcon-A 11.1
Keftab 11.1
Aluminum chlorohydrate 11.1
Croconazole hydrochloride 11.1
Nalfurafine hydrochloride 10.9
Zostrix 10.5
Alclometasone dipropionate 10.5
Alcaftadine 10.4
Patanol 10.2
Brompheniramine maleate 10.1
Pemirolast potassium 10.1
Pentyde 10.1
Gleptoferron 10.1
Olopatadine hydrochloride 9.7
Bepotastine besilate 9.6
Sulconazole nitrate 9.5
Elimite 9.5
Tiacrilast 9.5
Mometasone Furoate 9.5
Isoconazole nitrate 9.5
Clemastine fumarate 9.5
Crotamiton 9.4
Zyrtec 9.1
Aralen 9.1
Fenticonazole 9.1
Loprox 9.1
Pramiconazole 9.1
Calamine 9.0
Pimecrolimus 8.8
Zyrtec 8.8
Pemirolast 8.8
OncoScint 8.8
Ultravate 8.8
Proctosedyl 8.8
Apafant 8.6
Benzoic Acid 8.5
Alesion 8.5
Dimethindene maleate 8.5
Lomexin 8.5
Ebastine 8.5
Mizolastine 8.3
Cerebyx 8.3
Livostin 8.3
Levocabastine 8.3
Ethambutol hydrochloride 8.3
Periactin 8.2
Sertaconazole 8.2
Colestimide 8.1
Tazorac 8.1
Desoximetasone 8.1
Bupleurum root 7.9
Gris-PEG 7.9
Solganal 7.9
Dobutrex 7.9
Clocortolone pivalate 7.9
Tacalcitol 7.9
Atarax 7.9
Fluticasone propionate 7.8
Mectizan 7.8
Betamethasone dipropionate 7.8
Ultiva 7.8
Doxepine 7.8
Ogen 7.8
Flixotide 7.7
Dobutrex 7.6
Adapalene 7.6
Ophthetic 7.6
Ophthetic 7.6
Fosphenytoin 7.4
Gimeracil 7.4
Flurbiprofen axetil 7.4
Quinine sulfate 7.4
Bactroban 7.3
Epinastine 7.3
Amifloxacin 7.3
Uncaria hook 7.3
Selenium sulfide 7.3
Pevaryl 7.3
Amethocaine 7.3
Selamectin 7.2
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Enzyme
BAST 7.9
stratum corneum chymotryptic enzyme 6.8
KLK7 6.6
NAAT 5.6
tryptase 5.5
sphingomyelinase D 5.4
cathepsin S 4.9
5beta-reductase 4.9
lysophospholipase D 4.9
neuropsin 4.8
endoglycoceramidase 4.8
gamma-glutamyl transpeptidase 4.5
chymopapain 4.4
chymopapain 4.3
alpha-methylacyl-CoA racemase 4.3
ubiquitin-protein ligase 4.3
SOR 4.1
histidine decarboxylase 4.0
SRR 4.0
IOR 3.9
LTA4 hydrolase 3.9
ATP diphosphohydrolase 3.8
calcineurin 3.8
GMT 3.7
Der p 1 3.7
type III procollagen 3.7
carboxypeptidase G2 3.6
ferrochelatase 3.6
alkaline phosphatase 3.6
histamine N-methyltransferase 3.6
Rex 3.6
AST 3.5
kynurenine 3-monooxygenase 3.5
alanine aminotransferase 3.4
transpeptidase 3.4
AAE 3.4
chymase 3.3
diamine oxidase 3.3
glutamic dehydrogenase 3.3
aspartate aminotransferase 3.2
PPH 3.2
ornithine transcarbamylase 3.2
isoleucyl-tRNA synthetase 3.1
bile salt hydrolase 3.1
biliverdin reductase 3.0
ceramidase 2.7
CPM 2.7
phosphatidylinositol 4-kinase 2.7
monoacylglycerol lipase 2.7
proteinase-3 2.7
SOR 2.6
nucleotide pyrophosphatase 2.6
matriptase 2.5
MCS 2.5
phospholipase A1 2.4
phosphodiesterase 2.3
factor D 2.3
hexosaminidase 2.3
C3 convertase 2.2
chymosin 2.2
matriptase 2.1
bromelain 2.1
C3 convertase 2.1
CYP27A1 2.0
SPT 2.0
leucine aminopeptidase 2.0
papain 2.0
kallikrein 2.0
meprin 2.0
thromboxane synthase 2.0
fumarase 2.0
focal adhesion kinase 1.9
MTD 1.9
arylsulfatase 1.8
trypsin 1.8
endothelin-converting enzyme 1.8
plasmin 1.8
DCF 1.7
GTP cyclohydrolase I 1.7
enterokinase 1.7
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Compound
2-cyclohexylacetamide 11.1
Methdilazine 10.1
Fenistil 9.6
1-piperazinecarboxylic acid 9.1
Dimethyl cyanocarbonimidodithioate 9.1
Olopatadine 9.0
Naphthol AS 8.6
Tegin 8.5
Dexchlorpheniramine 8.5
Nodakenin 8.5
Doxepin hydrochloride 8.4
8-azabicyclo[3.2.1]octan-3-ol 8.3
1,2-decanediol 8.3
Azatadine 8.3
5-methylproline 8.3
Urushiol 8.3
Fosphenytoin 8.3
Diphenylcyclopropenone 8.2
8-azabicyclo[3.2.1]octan-3-ol 8.1
Cetirizine 8.0
Ursodeoxycholic acid 8.0
8-azabicyclo[3.2.1]octan-3-ol 7.9
butyl salicylate 7.9
Cyproheptadine hydrochloride 7.9
Benzanthrone 7.8
Azelastine 7.8
Hypolaetin 7.8
Tazarotene 7.7
Iodoquinol 7.6
Arildone 7.6
Vasocon 7.6
Quaternium-15 7.5
bromic acid 7.5
Disopyramide phosphate 7.5
Sulconazole 7.5
Econazole nitrate 7.4
Glycyrrhizinic acid 7.4
Dobutrex 7.4
Pectolinarigenin 7.4
Talampicillin 7.3
Ciclopirox olamine 7.3
Doxepin 7.2
Fexofenadine 7.2
Prednisolone acetate 7.2
Oxatomide 7.2
Flunisolide 7.1
Squaric acid 7.1
Emedastine 7.1
Mometasone furoate 7.1
Terfenadine 7.1
Trimeprazine 7.0
Fluocinonide 6.9
Monoethyl phthalate 6.9
benzyl benzoate 6.9
Pyrvinium 6.8
Glycin 6.8
Inox 6.8
Chlorpheniramine 6.8
RP 1 6.8
Dexpanthenol 6.7
Chlorpheniramine 6.7
Brompheniramine 6.7
Polidocanol 6.7
Papaverine hydrochloride 6.7
1,2-octanediol 6.7
Clemastine 6.7
Brinzolamide 6.6
2-furylmethyl 6.6
Menthone 6.6
Phthalic anhydride 6.6
Diethylcarbamazine 6.6
Dilaudid 6.5
Mercurochrome 6.5
Aurothioglucose 6.5
Halofantrine 6.5
Bitrex 6.5
Indoxyl 6.5
Ivermectin 6.4
palmitamide 6.4
Oxymorphone 6.4
more...