Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0033774 (pruritus)
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Human Gene/Protein
ENTPD3 protein 11.1
ANKRD13D 11.1
HECT domain containing 3 11.1
prion protein precursor 11.1
B1F3 11.1
ANKRD13B 11.1
ANKRD13A 11.1
Itch 11.1
MRGPRX1 10.4
MRGPRX4 10.1
CCDC47 10.1
Kallikrein 5 9.8
IL-31 9.6
USP53 9.5
TDRD10 9.5
ARRDC1 9.5
MRGPRD 9.1
GGT 2 9.1
Neuromedin B receptor 9.1
LIG-1 9.1
TRPV3 protein 8.8
CD39L3 8.8
TrpV3 8.8
HECW1 8.8
CFEOM2 8.8
MRGPRX2 8.7
RNF11 8.5
APC7 8.5
constitutive photomorphogenic protein 8.5
SREB3 8.5
ENTPD3 8.5
NDFIP2 8.5
oncostatin M receptor 8.5
intelectin 2 8.5
histamine H4 receptor 8.5
NEDL1 8.4
Prepronociceptin 8.3
ABCB4 protein 8.3
TAFA4 8.3
GRPR 8.1
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Disease
Harara 11.1
Hyaluronidase allergy 11.1
Infestation by land leeches 11.1
Cutaneous onchocerciasis 11.1
Erythema gyratum 11.1
parasitic eye infection 11.1
vagabond's disease 11.1
Itch mite infestation 11.1
Diffuse dermatitis 11.1
Subacute prurigo 11.1
Subacute myelomonocytic leukemia 11.1
pruritus 11.1
Apocrine nevus 11.1
anemia; progressive 11.1
Pruritus senilis 11.1
Itching purpura 11.1
Alopecia, drug 11.1
High turnover osteopathy 11.1
copra itch 11.1
Mixed ductal-endocrine carcinoma 11.1
Aquagenic pruritus 11.0
psychogenic pruritus 10.8
Epidermolysis bullosa pruriginosa 10.7
Chronic prurigo 10.5
Benign recurrent intrahepatic cholestasis 10.2
Eczematid-like purpura of Doucas and Kapetanakis 10.1
Anogenital lichen sclerosus 10.1
Childhood lichen sclerosus 10.1
parasitophobia 10.1
Plane xanthoma 10.1
Autoimmune urticaria 10.1
Chronic allergic conjunctivitis 10.1
Thrombosed haemorrhoids 10.1
Acquired reactive perforating dermatosis 10.1
Compulsive skin picking 10.1
parasitic skin disorder 10.1
Generalized eruptive keratoacanthoma 10.1
craw-craw 10.1
Skin and subcutaneous tissue disorders 10.1
Seasonal allergic conjunctivitis 10.1
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Symptom
Vulvovaginal pruritus 11.1
Cholestatic pruritus 11.1
Vesical tenesmus 11.1
Ear pruritus 11.1
Drug-induced pruritus 11.1
Anal irritation 11.1
Anogenital pruritus 11.1
Tongue symptoms 11.1
Pruritus scroti 11.1
Oral pruritus 11.1
Scalp pruritus 10.7
Generalized pruritus 10.7
Pruritus of pregnancy 10.5
Pruritus vulvae 10.5
Vulvovaginal pain 10.1
Cholinergic pruritus 10.1
General symptoms and signs 10.1
vaginal discomfort 10.0
redness of the eyes 9.3
Juvenile spring eruption 9.3
Intermittent diarrhea 9.1
Vulval pain 9.1
skin tenderness 9.1
Anal symptoms 9.1
Darier's sign 8.9
sneezing 8.9
skin pain 8.8
Sharp pain 8.8
symptom or complaint 8.8
runny eyes 8.8
prickling sensation 8.8
Auspitz's sign 8.8
dry skin 8.7
Skin symptoms 8.6
inflammation of the vulva 8.5
Upper back pain 8.5
Postoperative nausea 8.5
vulval irritation 8.3
nasal congestion 8.1
Breast tenderness 8.0
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Drug
Naphcon-A 11.1
Aluminum chlorohydrate 11.1
Croconazole hydrochloride 11.1
Keftab 11.1
Nalfurafine hydrochloride 10.9
Zostrix 10.5
Alclometasone dipropionate 10.5
Alcaftadine 10.4
Patanol 10.2
Brompheniramine maleate 10.1
Gleptoferron 10.1
Pentyde 10.1
Pemirolast potassium 10.1
Olopatadine hydrochloride 9.7
Bepotastine besilate 9.6
Elimite 9.5
Sulconazole nitrate 9.5
Isoconazole nitrate 9.5
Clemastine fumarate 9.5
Tiacrilast 9.5
Mometasone Furoate 9.5
Crotamiton 9.4
Aralen 9.1
Zyrtec 9.1
Fenticonazole 9.1
Loprox 9.1
Pramiconazole 9.1
Calamine 9.0
Pimecrolimus 8.8
OncoScint 8.8
Proctosedyl 8.8
Pemirolast 8.8
Zyrtec 8.8
Ultravate 8.8
Apafant 8.6
Alesion 8.5
Lomexin 8.5
Benzoic Acid 8.5
Dimethindene maleate 8.5
Ebastine 8.5
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Enzyme
BAST 7.9
stratum corneum chymotryptic enzyme 6.8
KLK7 6.6
NAAT 5.6
tryptase 5.5
sphingomyelinase D 5.4
cathepsin S 4.9
5beta-reductase 4.9
lysophospholipase D 4.9
neuropsin 4.8
endoglycoceramidase 4.8
gamma-glutamyl transpeptidase 4.5
chymopapain 4.4
chymopapain 4.3
alpha-methylacyl-CoA racemase 4.3
ubiquitin-protein ligase 4.3
SOR 4.1
histidine decarboxylase 4.0
SRR 4.0
IOR 3.9
LTA4 hydrolase 3.9
ATP diphosphohydrolase 3.8
calcineurin 3.8
GMT 3.7
Der p 1 3.7
type III procollagen 3.7
carboxypeptidase G2 3.6
ferrochelatase 3.6
alkaline phosphatase 3.6
histamine N-methyltransferase 3.6
Rex 3.6
AST 3.5
kynurenine 3-monooxygenase 3.5
alanine aminotransferase 3.4
transpeptidase 3.4
AAE 3.4
chymase 3.3
diamine oxidase 3.3
glutamic dehydrogenase 3.3
aspartate aminotransferase 3.2
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Compound
2-cyclohexylacetamide 11.1
Methdilazine 10.1
Fenistil 9.6
1-piperazinecarboxylic acid 9.1
Dimethyl cyanocarbonimidodithioate 9.1
Olopatadine 9.0
Naphthol AS 8.6
Tegin 8.5
Nodakenin 8.5
Dexchlorpheniramine 8.5
Doxepin hydrochloride 8.4
Azatadine 8.3
5-methylproline 8.3
Urushiol 8.3
1,2-decanediol 8.3
8-azabicyclo[3.2.1]octan-3-ol 8.3
Fosphenytoin 8.3
Diphenylcyclopropenone 8.2
8-azabicyclo[3.2.1]octan-3-ol 8.1
Cetirizine 8.0
Ursodeoxycholic acid 8.0
Cyproheptadine hydrochloride 7.9
8-azabicyclo[3.2.1]octan-3-ol 7.9
butyl salicylate 7.9
Benzanthrone 7.8
Azelastine 7.8
Hypolaetin 7.8
Tazarotene 7.7
Arildone 7.6
Iodoquinol 7.6
Vasocon 7.6
bromic acid 7.5
Quaternium-15 7.5
Disopyramide phosphate 7.5
Sulconazole 7.5
Econazole nitrate 7.4
Dobutrex 7.4
Glycyrrhizinic acid 7.4
Pectolinarigenin 7.4
Talampicillin 7.3
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