Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0033774 (pruritus)
 14,546 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 942
Itch 622
IgE 545
She 322
scratch 288
alkaline phosphatase 259
mast cell 257
cytokine 214
substance P 170
Mol 131
opioid receptor 127
ubiquitin 111
IL-4 110
calcineurin 108
collagen 106
albumin 104
interferon 103
chronic renal failure 95
IL-31 85
TRPV1 85
CD4 75
IL-13 75
TNF 66
E3 ubiquitin ligase 64
parathyroid hormone 64
nerve growth factor 62
aspartate aminotransferase 61
calcitonin 60
IL-6 60
alanine aminotransferase 59
lymphoid 58
insulin 58
TRPA1 58
Pol 57
gastrin-releasing peptide 56
tumor necrosis factor 56
thymic stromal lymphopoietin 55
ICP 54
hemoglobin 51
IgA 49
epidermal growth factor receptor 47
ASA 44
histamine H1 receptor 44
phosphodiesterase 43
Rec 43
reserved 43
CO2 43
filaggrin 41
IFN 41
IL-5 39
tyrosine kinase 38
IL-10 36
lamp 36
CD8 35
bradykinin 35
gut 35
hairless 34
gastrin-releasing peptide receptor 34
Alagille syndrome 34
IL-17 34
transient receptor potential vanilloid 1 33
p53 33
serum albumin 32
Pseudomonas 32
AST 32
JAK2 32
proteasome 31
ubiquitin ligase 30
MRI 30
kappa opioid receptor 28
Janus kinase 28
ABCB11 27
5-hydroxytryptamine 27
erythropoietin 27
cyclooxygenase 27
ankyrin 1 27
prothrombin 26
IL-33 26
BP180 26
gamma-glutamyl transpeptidase 26
somatostatin 25
Autotaxin 25
bile salt export pump 25
interleukin-4 25
PCA 24
interleukin-2 24
IL-2 24
CAS 24
polypeptide 24
PAR-2 23
HLA 23
keratin 23
G protein-coupled receptor 23
STD 23
IFN-gamma 23
lipopolysaccharide 22
C-reactive protein 21
p38 21
MAPK 21
PBC 21
chemokine 21
TNF-alpha 21
calcium channel 21
IL-8 21
C1 inhibitor 20
mucin 20
JNK 20
histamine H4 receptor 20
axonal 20
COL7A1 20
ferritin 19
interferon-gamma 19
hairy 19
bombesin 19
ERK 19
PTH 19
EGFR 19
neuropeptide Y 18
TRPV3 18
PD-1 18
CSF 18
ABCB4 18
GPT 18
type VII collagen 18
proteinase-activated receptor-2 18
ATP 18
gamma-glutamyltransferase 18
beta-endorphin 17
dynorphin 17
ENT 17
TRPM8 17
TRP 17
San 17
JAMA 17
eosinophil cationic protein 17
thymus 16
AIF4 16
parathormone 16
DRG 16
BRAF 16
mu opioid receptor 16
5-lipoxygenase 16
STAT 15
lactate dehydrogenase 15
TCR 15
calcineurin inhibitor 15
GABA 15
PGP 9.5 15
IL-23 15
IL-1 15
CD20 15
glycoprotein 14
CRP 14
Ubiquitin 14
CD25 14
cytochrome P450 14
protease inhibitor 14
GTG 14
p63 14
serine protease 14
more...
Disease
pruritus 14546
atopic dermatitis 1504
rash 849
dermatitis 789
skin disease 751
urticaria 746
cholestasis 702
cancer 699
psoriasis 555
depression 494
eczema 490
asthma 435
allergic rhinitis 417
tumor 393
Contact Dermatitis 339
liver disease 293
primary biliary cirrhosis 268
eosinophilia 233
infestation 227
cirrhosis 213
diabetes 212
scabies 210
anaphylaxis 200
cold 194
prurigo 191
rhinitis 189
xerosis 179
hepatitis 173
cholangitis 169
carcinoma 163
lymphadenopathy 159
conjunctivitis 149
anemia 148
plaque 147
allergic conjunctivitis 142
acne 140
hypertension 139
chronic renal failure 137
HIV 136
lichen planus 133
lymphoma 127
pemphigoid 122
melanoma 120
chronic pain 120
primary sclerosing cholangitis 116
chronic urticaria 114
seborrheic dermatitis 114
erythroderma 113
renal disease 112
infectious diseases 111
vaginal discharge 110
fungal infection 108
lichen sclerosus 103
onchocerciasis 100
hyperkeratosis 100
renal failure 96
lice 89
mastocytosis 88
vasculitis 88
food allergy 87
ICP 86
hay fever 86
hyperparathyroidism 83
vitiligo 82
piles 82
conjunctiva 82
candidiasis 81
metastases 81
hepatitis C 81
polycythemia vera 78
AIDS 78
vagina 78
malaria 77
vaginitis 76
squamous cell carcinoma 74
Hodgkin's disease 74
mycosis fungoides 71
chronic liver disease 71
lichen 70
leukemia 70
thrombocytopenia 70
herpes zoster 70
neuropathy 69
immunodeficiency 68
autoimmune disease 68
obstructive jaundice 67
photosensitivity 67
breast cancer 66
ichthyosis 65
virus infection 64
systemic disease 64
herpes simplex 64
ichthyosis 63
cutaneous T-cell lymphoma 63
STD 63
pneumonia 61
folliculitis 61
adenocarcinoma 60
inflammatory bowel disease 60
portal hypertension 59
rosacea 59
purpura 58
herpes 58
arthritis 57
chronic hepatitis 56
incontinence 55
systemic lupus erythematosus 55
osteoporosis 54
epidermolysis bullosa 53
biliary obstruction 53
rheumatoid arthritis 52
xerostomia 52
lichen simplex chronicus 51
acne vulgaris 51
influenza 51
lupus 51
amyloidosis 51
worms 51
Infection 50
dermatitis herpetiformis 50
neutropenia 49
viral hepatitis 49
bacterial infection 48
sepsis 48
pemphigus 48
varicella 47
blindness 47
mange 47
sleep disturbances 47
warts 47
skin cancer 46
rare disease 45
keratoconjunctivitis 45
alopecia areata 45
bacterial vaginosis 45
gallstones 45
West 45
volvulus 44
PDB 43
obesity 42
urticaria pigmentosa 42
uremia 42
sepsis 41
colitis 41
incontinence 41
hepatocellular carcinoma 41
postherpetic neuralgia 41
dermatomyositis 41
malnutrition 41
mole 41
prolapse 41
Onchocerciasis 40
ulcerative colitis 40
tuberculosis 40
telangiectasia 39
erythema multiforme 39
vulvovaginitis 39
genital warts 38
chronic disease 38
sarcoidosis 38
more...
Symptom
pain 2566
erythema 1092
nausea 704
analgesia 559
vomiting 526
fatigue 454
sneezing 416
headache 391
anesthesia 360
diarrhea 356
discomfort 294
discomfort 290
rhinorrhea 248
abdominal pain 240
cough 202
nausea and vomiting 193
dry skin 189
Welt 185
dizziness 179
dyspnea 165
sleepiness 164
flushing 154
nasal congestion 140
weakness 140
anorexia 122
constipation 117
paresthesia 104
insomnia 103
arthralgia 102
tingling 101
Ill 96
splenomegaly 83
wheezing 82
photophobia 76
dysuria 75
myalgia 73
hepatomegaly 71
chills 71
numbness 70
bone pain 67
back pain 65
skin irritation 60
asthenia 52
shortness of breath 48
seizures 47
acute pain 45
nasal discharge 40
lethargy 40
night sweats 38
agitation 38
blurred vision 36
hepatosplenomegaly 36
collapse 35
tense 34
abdominal discomfort 32
chest pain 31
cancer pain 28
dry eye 28
thinning 28
skin damage 28
syncope 27
tinnitus 27
pallor 27
otalgia 27
ataxia 27
dysesthesia 26
vertigo 25
respiratory distress 24
chest tightness 23
sore throat 23
Wind 21
dark urine 21
Sedation 21
epigastric pain 20
hoarseness 20
low back pain 18
angina 17
Generalized pruritus 17
ENT 17
Postoperative pain 16
Scratch 16
decreased appetite 16
skin pain 16
scaly skin 15
muscle cramps 15
tremor 14
spasm 14
anal pain 14
heartburn 13
hot flushes 13
throat irritation 13
stigma 13
neuralgia 12
paresis 12
Skin symptoms 12
stridor 11
Darier's sign 11
colic 11
stomach pain 11
urinary frequency 11
shoulder pain 11
abdominal cramps 11
hyperesthesia 11
exhaustion 11
right upper quadrant pain 11
polydipsia 11
eye pain 10
vaginal discomfort 10
Nasal symptoms 10
livedo 10
generalized erythema 10
chronic cough 9
pelvic pain 9
Vulvodynia 9
vestibulitis 9
spasticity 8
clubbing 8
cyanosis 8
redness of the eyes 8
anosmia 8
tachypnea 8
apathy 8
giddiness 8
giddiness 8
urethral discharge 8
rectal pain 8
postnasal drip 8
generalized rash 7
bloating 7
breakthrough pain 7
tenesmus 7
functional recovery 7
hyperemesis gravidarum 7
hypothermia 7
enuresis 7
hypalgesia 7
cachexia 7
rigors 7
stuffy nose 7
facial pain 6
dyschezia 6
myoclonus 6
fever of unknown origin 6
Scalp pruritus 6
neck pain 6
distraction 6
Crawling 6
glossodynia 6
dysarthria 6
Gastrointestinal symptoms 6
Burning 6
excessive sweating 6
memory loss 6
polyuria 6
lassitude 5
oliguria 5
swollen joints 5
eye discharge 5
acute stress 5
dental pain 5
more...
Drug
Dermatol 2251
Histamine 141
Asthma 139
Tacrolimus 48
Dial 36
Allergen 35
CSF 29
Fentanyl 24
Nephron 24
IL-2 24
Pimecrolimus 24
Nephron 22
Imiquimod 21
IFN-gamma 21
PTH 20
Gabapentin 19
ENT 19
niacin 17
vitamin E 16
Loratadine 14
Bupivacaine 13
Acyclovir 13
Olopatadine hydrochloride 13
Prednisolone 12
Ketotifen 12
Fluticasone propionate 12
lysine 12
Pregabalin 11
Omalizumab 11
Mectizan 11
Ketoconazole 11
ampicillin 10
nitroglycerin 10
Prograf 10
Retinoic acid 10
Ebastine 10
Prednisone 10
Levocabastine 9
Clobetasol propionate 9
Gefitinib 9
lactose 9
Norplant 9
Cardiovasc 9
EE2 8
Fluconazole 8
Aloe 8
Diphenhydramine 8
Ipilimumab 8
Auranofin 8
caffeine 7
Gel 7
Portal 7
Leaf 7
OTC 7
IPM 7
ADR 7
Albumin 7
OTC 7
MAP 7
HCH 7
Adapalene 7
Fosphenytoin 7
Sorafenib 7
Infliximab 6
Norplant 6
Calcipotriol 6
Cetuximab 6
Ketorolac 6
Aprepitant 6
Isotretinoin 6
Dakar 6
Erlotinib 6
Biopolymers 6
Nalfurafine hydrochloride 6
Spectrum 6
Methylprednisolone 6
Captopril 6
CPO 6
Indomethacin 6
Infliximab 6
Nedocromil sodium 6
CTX 6
Patanol 6
Crotamiton 5
Isoniazid 5
Ranitidine 5
Mirtazapine 5
Flixotide 5
ascorbate 5
EPI 5
Budesonide 5
Sertaconazole 5
Estrogens 5
ZnO 5
Adalimumab 5
Mizolastine 5
Doxycycline 4
Amoxicillin 4
Imatinib 4
CTX 4
Xylocaine 4
Ketorolac tromethamine 4
Retinoic Acid 4
Calamine 4
Mometasone furoate 4
Bepotastine besilate 4
Propofol 4
Tranilast 4
Zyrtec 4
Ofloxacin 4
Xylocaine 4
Xylocaine 4
Encore 4
Fenticonazole 4
Serum albumin 4
CTX 4
ALA 4
p75 4
citric acid 4
Lenalidomide 4
Alefacept 4
Menthol 3
Alcaftadine 3
Flunisolide 3
Bifidobacterium 3
Vitamin A 3
Clonidine 3
EPA 3
Dithranol 3
Zyrtec 3
Fraction 3
Triclosan 3
Fansidar 3
Trib 3
Fansidar 3
Cimetidine 3
9-THC 3
Betamethasone dipropionate 3
Periactin 3
Butorphanol 3
Coal tar 3
Selamectin 3
Adriamycin 3
Zaditen 3
Diclofenac sodium 3
Honey 3
Atarax 3
Acitretin 3
Cimetidine 3
Depo-Provera 2
Timolol 2
Leucovorin 2
IL-1ra 2
Check 2
Artemether 2
BoNT/A 2
Ginger 2
Glycyrrhiza 2
Tacalcitol 2
Sodium citrate 2
more...
Enzyme
alkaline phosphatase 259
alanine aminotransferase 129
calcineurin 109
ERK 94
aspartate aminotransferase 92
gamma-glutamyl transpeptidase 92
focal adhesion kinase 76
trypsin 69
mitogen-activated protein kinase 60
tryptase 58
phosphodiesterase 43
proteasome 34
AST 32
peroxidase 18
protein kinase C 17
protein kinase 15
lactate dehydrogenase 15
acetylcholinesterase 14
plasmin 14
cholinesterase 13
phospholipase C 12
superoxide dismutase 12
papain 12
histidine decarboxylase 11
diamine oxidase 11
kallikrein 11
ACE 10
creatine kinase 10
MEK 10
phospholipase A2 9
collagenase 9
hexosaminidase 8
KLK7 8
lysozyme 8
luciferase 8
ACS 7
ubiquitin-protein ligase 7
ornithine transcarbamylase 7
lipase 7
transpeptidase 7
cathepsin S 7
catalase 6
CYP3A4 6
ATPase 6
transglutaminase 6
P-glycoprotein 6
tyrosine hydroxylase 6
chymase 6
reverse transcriptase 5
NOS 5
thrombin 5
Rex 5
thromboplastin 5
urease 5
urease 5
tyrosinase 5
ferrochelatase 5
adenylate cyclase 5
prostate-specific antigen 4
monoamine oxidase 4
chymopapain 4
caspase-8 4
APC 4
granzyme B 4
xanthine oxidase 4
type III procollagen 4
CD10 4
pyruvate dehydrogenase 4
NO synthase 4
chymopapain 4
glutathione S-transferase 3
asparaginase 3
thyroid peroxidase 3
leucine aminopeptidase 3
beta-lactamase 3
DCF 3
phosphatidylinositol 3-kinase 3
endonuclease 3
lysophospholipase D 3
sulfatase 3
lipoxygenase 3
glutamate dehydrogenase 2
bromelain 2
indoleamine 2,3-dioxygenase 2
lactase 2
C3 convertase 2
SOR 2
RNA polymerase 2
caspase-3 2
C3 convertase 2
Mg2+-ATPase 2
5'-nucleotidase 2
Der p 1 2
AOR 2
AMP-activated protein kinase 2
MAT 2
tissue plasminogen activator 2
GMT 2
neuropsin 2
acid phosphatase 2
LTA4 hydrolase 2
aldehyde dehydrogenase 2
MCS 2
fumarase 2
glutathione peroxidase 2
monoacylglycerol lipase 2
PDE 2
BMT 2
CPM 2
stratum corneum chymotryptic enzyme 2
glucose-6-phosphate dehydrogenase 2
MAT 2
hyaluronidase 2
arylsulfatase 2
IKK 2
elastase 2
glutamate dehydrogenase 2
SOR 2
hyaluronidase 2
beta-glucuronidase 2
glutamate dehydrogenase 2
chymotrypsin 2
lipoprotein lipase 2
PRA 2
alpha-amylase 2
phosphatidylinositol 4-kinase 2
isoleucyl-tRNA synthetase 1
GAS 1
CaMKII 1
caspase-1 1
TSA 1
histamine N-methyltransferase 1
transcriptase 1
PRE 1
endoglycoceramidase 1
glutamine synthetase 1
factor D 1
DNA polymerase 1
apyrase 1
carbonic anhydrase 1
ATP diphosphohydrolase 1
topoisomerase 1
caspase-9 1
nucleotide pyrophosphatase 1
MEKK1 1
MTD 1
dihydrofolate reductase 1
cholesterol acyltransferase 1
MDH 1
matriptase 1
aequorin 1
kynurenine 3-monooxygenase 1
PNGase F 1
demethylase 1
12-lipoxygenase 1
FAST 1
prolyl hydroxylase 1
proteinase-3 1
ceramidase 1
enolase 1
more...
Compound
Clin 1272
Dec 952
water 372
calcium 272
sodium 199
Histamine 141
DNA 128
phosphate 111
creatinine 99
oxygen 95
His 80
urea 78
glucose 75
sulfate 70
salt 69
Ursodeoxycholic acid 69
potassium 67
TNF 66
5-HT 65
CO2 64
vitamin D 59
zinc 53
ethanol 52
ASA 52
acetate 52
nickel 51
FK506 50
Morphine 46
nitrogen 44
hydroxide 43
iron 43
nitric oxide 41
phosphorus 40
Ivermectin 37
Dial 36
Capsaicin 35
galactose 35
aluminum 34
alanine 33
salicylic acid 33
copper 32
acetone 31
tryptophan 31
Substance P 30
nitrate 30
Pac 28
iodine 27
KOH 27
Cetirizine 26
glutamate 26
arginine 25
Chloroquine 25
retinoic acid 25
serine 25
Chloroquine 25
Cyclosporine 24
tyrosine 24
Rifampicin 22
formaldehyde 21
PGE2 21
cysteine 20
hyaluronic acid 20
6-12 19
formaldehyde 19
Estrogen 19
GPT 18
Cbl 18
benzyl benzoate 18
ATP 18
silver 18
Naltrexone 18
PGD2 17
adenosylmethionine 17
Cardiol 17
NH2 17
sodium chloride 17
Azelastine 17
Vancomycin 16
PEG 16
lysine 16
GABA 15
GABA 15
A 42 15
Terfenadine 15
CAP 15
hydrogen 15
CAM 15
A 3 15
propylene glycol 15
leucine 15
HCl 15
noradrenaline 15
Parenteral 15
propylene glycol 14
CAP 14
mercury 14
Optimal 13
Bupivacaine 13
Keloid 13
Naloxone 13
methionine 13
acetic acid 13
APAP 13
tryptophan 13
cobalt 13
methanol 13
Olopatadine 13
N-acetylcysteine 12
azelaic acid 12
H2S 12
Isoproterenol 12
tryptophan 12
toluene 12
Etretinate 12
Acyclovir 12
Gly 12
Estrogen 12
Lidocaine 12
tryptophan 12
Curcumin 12
ethyl acetate 12
Neuronal 12
Prednisolone 12
ALP 11
Ketoconazole 11
chromium 11
phenol 11
Ondansetron 11
1-chloro-2,4-dinitrobenzene 10
Prednisone 10
ammonium 10
PAS 10
DSS 10
Tazarotene 10
ADP 10
ADR 10
ammonia 10
NIDA 10
nicotinic acid 10
Disodium cromoglycate 10
Adrenal 10
DMSO 9
Ile 9
cAMP 9
Salix 9
Fenistil 9
Nodular 9
Buprenorphine 9
Diphenhydramine 9
PEG 9
Allyl isothiocyanate 9
ACTH 9
Miconazole 9
bromide 9
AMP 9
ADP 8
ADP 8
MEK 8
Dexamethasone 8
MOP 8
more...