Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0033774 (pruritus)
 14,546 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Papaverine hydrochloride taken by mouth in doses of 100 mg four to six times daily or in 150-mg timed-release capsules two or three times daily is often effective in significantly decreasing itching in patients with atopic dermatitis. When used orally, as described here, it does not appear to have beneficial effects in other itchy dermatoses. It should be used as adjuvant treatment in combination with other accepted forms of therapy, since it alone cannot reverse the chronic skin changes brought about by months or years of scratching and rubbing.
 ...
PMID:Papaverine therapy in atopic dermatitis. 407 76

Papaverine hydrochloride (150 to 300 mg/dog every 12 hours) and doxycycline hyclate (3 mg/kg every 12 hours) were both administered orally as individual agents to 13 dogs with pruritus of allergic or idiopathic origin. No dog improved. Depression, anorexia, and vomiting were seen in one dog treated with papaverine hydrochloride. Under the conditions of the study, papaverine and doxycycline were not useful antipruritic agents for the dog.
 ...
PMID:Failure of papyerine hydrocholoride and doxycycline hyclate as antipruritis agents in pruritic dogs: Results of an open clinical trial. 1742 84