Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0033774 (pruritus)
 14,546 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A clinical survey in Benin (Nigeria) has revealed that 393 out of 541 respondents experienced pruritus (itching) whenever they took chloroquine for malaria treatment. The reaction was always severe in 90% of the cases. Based on this experience, the pruritus-prone subjects were subsequently given antihistamine therapy either 30 min before or along with chloroquine administration (initial dose, 600 mg base oral, or 200 mg base i.m.). The success rates obtained with the following antihistamines were 49% (chlorpheniramine maleate, 4-8 mg oral), 46% (mepyramine maleate, 50-100 mg oral), and 60% (Promethazine hydrochloride, 50 mg oral or i.m.). Promethazine appears to be the most effective in the prevention of chloroquine-induced pruritus but the differences were not significant. The antihistamine was more frequently given 30 min before chloroquine, but this had no advantage over the concomitant administration of the two drugs, which may therefore be presented in one dosage form for a better treatment compliance.
 ...
PMID:Responsiveness of chloroquine-induced pruritus to antihistamine therapy--a clinical survey. 197 Dec 76

The cultural context of forest onchocerciasis was studied in the Boulou and Baka ethnic communities in the Dja-Lobo Division of southern Cameroon. A 2-day survey used focus group interviews followed by a questionnaire administered to 212 randomly selected individuals in 8 communities (88 male and 124 females heads of household) to assess their knowledge about onchocerciasis. Most people (98%) had some knowledge about the disease. Minak was the term used for filariasis by most people (97%) and people knew (90%) that black fly (nyamendimi) was responsible for its transmission. Other vectors of the illness identified were mosquitoes, dirty water, sorcery, and taboo foods. 81% thought that maternal transmission was possible and 66% indicated that filariasis could be transmitted sexually. Virtually all respondents associated itching and rash with minak (filariasis) and more than 60% also recognized the swelling of the skin and leopard skin as manifestations of filariasis. Filariasis, malaria, worms, and blindness were placed in the middle category when the severity of various diseases was ranked by 20 Boulou adults. In contrast, the Baka did not think that filariasis caused blindness, nor that it is linked to eye-worms. However, the 212 individuals ranked blindness as the most severe among other diseases (filaria, malaria, diarrhea, and intestinal worms). 80% of the Boulou and Baka adults had had filariasis in the previous year, but only 5% of the Boulou children and none of the Baka children had had filariasis during that time period. With respect to intestinal worms, 71% of the Boulou adults and 60% of the Baka adults had had intestinal worms in the previous year, while more than 90% of the Boulou children and all of the Baka children had had intestinal worms. Of the 90% who revealed that they had had filariasis at least once before, 69% sought treatment. 54% had tried traditional treatment, while 50% had tried Notezine, 49% had tried Phenergan, and 38% had tried M.G. Lumiere.
 ...
PMID:Ivermectin distribution and the cultural context of forest onchocerciasis in South Province, Cameroon. 864 8