Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033774 (pruritus)
 14,546 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fluticasone propionate is a fluoromethyl androstane 17beta-carbiothioate that is classified for dermatological use as a moderate potency corticosteroid. It is available in 0.05% cream and 0.005% ointment formulations for the treatment of patients with inflammatory dermatoses responsive to corticosteroids. Although it demonstrates greater activity than other corticosteroids of similar potency in vasoconstrictor assays in humans, fluticasone propionate demonstrates low potential to cause significant systemic effects such as suppression of the hypothalamopituitary-adrenal (HPA) axis. This is because it has a high affinity for the glucocorticoid receptor and high lipophilicity, and the small amount of drug that is absorbed is rapidly metabolised to the inactive carboxylic acid derivative in the liver (i.e. it has low systemic bioavailability). In clinical trials, the efficacy of fluticasone propionate cream at 4 weeks did not differ significantly from that of hydrocortisone butyrate 0.1% cream in patients with moderate to severe atopic dermatitis and betamethasone valerate 0.1% cream in patients with moderate to severe psoriasis. Likewise, after 4 weeks, the ointment form of fluticasone propionate had similar efficacy to betamethasone dipropionate 0.05% in patients with psoriasis or atopic dermatitis, although the latter agent may have a faster onset of activity in patients with atopic dermatitis. Fluticasone propionate ointment was generally more effective than hydrocortisone butyrate ointment in patients with psoriasis. A sustained response was usually observed after about 1 week's application of fluticasone propionate, and although once and twice daily administration had similar efficacy, a twice daily regimen may have a slightly faster onset of effect. In trials which included both adults and children, the only adverse events reported were local cutaneous reactions (most frequently, pruritus). Thus, fluticasone propionate, with its low potential for systemic toxicity and possible advantage of once daily administration, is a useful addition to the topical corticosteroids available for the treatment of psoriasis and atopic dermatitis.
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PMID:Topical fluticasone propionate: a review of its pharmacological properties and therapeutic use in the treatment of dermatological disorders. 1802 Apr 89

Pruritic urticarial papules and plaques of pregnancy (PUPPP) is among the most common dermatoses of pregnancy. Most reports of the effective treatment of PUPPP involve high potency topical corticosteroids or oral steroids. Many authorities have noted cases of PUPPP whose resolution followed parturition. A few have noted that PUPPP can arise and resolve the third trimester. A 36-year-old prima gravida at 38 weeks of gestation presented with a 2-week history of a pruritic papular abdominal eruption. She used fluticasone propionate 0.05 percent lotion twice a day. One week after starting this medication, the pruritus had resolved and the erythema/urticaria had abated; the pigmentary alteration had improved, but still remained. The PUPPP did not return after parturition. PUPPP can abate entirely during pregnancy. Fluticasone propionate 0.05 percent lotion, a class 5 (low-medium potency) corticosteroid, has a benign side effect profile and should be considered for the treatment of PUPPP during pregnancy.
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PMID:Pruritic urticarial papules and plaques of pregnancy wholly abated with one week twice daily application of fluticasone propionate lotion: a case report and review of the literature. 1909 42


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