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Query: UMLS:C0033774 (pruritus)
 14,546 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fifteen patients (10 women and 5 men; median age 46 years; range 28-55), with recurrent severe carpal tunnel syndrome, were operated on with re-exploration and cover of the median nerve with free or pedicled flaps (five pedicled ulnar flaps, one pedicled dorsal forearm flap (served by the posterior interosseus artery), one groin flap, three free scapular flaps, and five free lateral arm flaps). The patients were followed up by a self-administered questionnaire at 3 months-14 years (median 8.5 years) after operation and replies were obtained from 14 patients. There was a significant improvement in pain (p = 0.01) and percussion tenderness at the wrist (p = 0.02), but no significant improvement in allodynia and cold intolerance in the hand as evaluated by the use of a visual analogue scale (VAS). Three of the 14 patients had less numbness/paraesthesiae and four had subjectively improved sensory function in the hand and fingers since the procedure. Ten patients had problems from the donor site, including a cosmetically unacceptable scar, allodynia, and itching. Four patients had worked before the operation and nine patients returned to ordinary or light work afterwards. In conclusion, 10/14 patients considered themselves as somewhat better, better, or cured, while four felt that they were unchanged or worse. We conclude that cover with vascularised fat may be worthwhile in some patients with recurrent severe carpal tunnel syndrome, preferably with a simple pedicled ulnar flap.
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PMID:Coverage of the median nerve with free and pedicled flaps for the treatment of recurrent severe carpal tunnel syndrome. 1214 Dec 6

We evaluated the postoperative pain relief and side-effects of continuous epidural infusion of three analgesic regimens following major thoracic and/or abdominal surgery. One hundred and twenty patients were randomly divided into three treatment groups: (1) 0.25% or 0.5% bupivacaine at a rate of 3-7 ml.hr(-1), (2) 0.01% morphine at a rate of 1-2 ml.hr(-1), (3) a combination of 0.125% or 0.25% bupivacaine and 0.0025% or 0.005% morphine at a rate of 2-4 ml.hr(-1). The study continued for the first 48 postoperative hours. The effect of pain relief was evaluated by assessment of the further requirement for parenteral analgesics. Sixty-four percent of the patients given bupivacaine, 56% of the patients given morphine and 80% of the patients given the combination required no supplemental analgesics. Continuous epidural infusion of bupivacaine was associated with hypotension (21%) and with numbness and weakness of hands or legs (18%). Continuous epidural infusion of morphine was associated with pruritus (18%) and with peristaltic depression (12%). The combination regimen was associated with pruritus (17%) and with drowsiness (14%). We conclude that the combination of bupivacaine and morphine significantly provides superior analgesia with less deleterious complications compared with either bupivacaine or morphine alone.
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PMID:Continuous epidural infusion for postoperative pain relief: a comparison of three regimens. 1523 98

This paper reviews a wide range of somatization-related symptoms that are encountered in dermatology. These include the unexplained cutaneous sensory syndromes especially the cutaneous dysesthesias associated with pain, numbness and pruritus; traumatic memories in post-traumatic stress disorder (PTSD) which are experienced on a sensory level as 'body memories' and may present as local or generalized pruritic states, urticaria and angioedema; and unexplained flushing reactions and profuse perspiration, in addition to unexplained exacerbations of stress-reactive dermatoses such as psoriasis and atopic eczema secondary to the autonomic hyperarousal in PTSD; classic 'pseudoneurologic' symptoms associated with dissociation including unexplained loss of touch or pain, in addition to the self-induced dermatoses such as dermatitis artefacta and trichotillomania that are encountered with dissociative states; and body dysmorphic disorder where the patient often presents with a somatic preoccupation involving the skin or hair.
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PMID:Somatization disorders in dermatology. 1645 79

We report a case of food-induced anaphylaxis caused by ingestion of royal jelly. After taking royal jelly and several other medicinal products, a 33-year-old Japanese male developed severe facial pruritus and erythema, followed by vertigo, numbness in his fingers, generalized pruritus, wheals, dyspnea, wheezing and impaired consciousness. He was treated with corticosteroid and fluid therapy, and his symptoms subsided. Upon allergy testing, his only positive reaction was to royal jelly. Given the clinical symptoms and the positive prick test to royal jelly, a diagnosis of anaphylaxis due to the ingestion of royal jelly was made. In this paper, we describe this case and review the relevant published work.
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PMID:Food-induced anaphylaxis caused by ingestion of royal jelly. 1670 Aug 35

The Agency for Toxic Substances and Disease Registry (ATSDR) prepared this health consultation to provide support for assessing the public health implications of hazardous chemical exposure, primarily through drinking water, related to releases of chromated copper arsenate (CCA) in the port of Djibouti. CCA from a shipment, apparently intended for treating electric poles, is leaking into the soil in the port area. CCA is a pesticide used to protect wood against decay-causing organisms. This mixture commonly contains chromium(VI) (hexavalent chromium) as chromic acid, arsenic(V) (pentavalent arsenic) as arsenic pentoxide and copper (II) (divalent copper) as cupric oxide, often in an aqueous solution or concentrate. Experimental studies of the fate of CCA in soil and monitoring studies of wood-preserving sites where CCA was spilled on the soil indicate that the chromium(VI), arsenic and copper components of CCA can leach from soil into groundwater and surface water. In addition, at CCA wood-preserving sites, substantial concentrations of chromium(VI), arsenic and copper remained in the soil and were leachable into water four years after the use of CCA was discontinued, suggesting prolonged persistence in soil, with continued potential for leaching. The degree of leaching depended on soil composition and the extent of soil contamination with CCA. In general, leaching was highest for chromium(VI), intermediate for arsenic and lowest for copper. Thus, the potential for contamination of sources of drinking water exists. Although arsenic that is leached from CCA-contaminated soil into surface water may accumulate in the tissues of fish and shellfish, most of the arsenic in these animals will be in a form (often called fish arsenic) that is less harmful. Copper, which leaches less readily than the other components, can accumulate in tissues of mussels and oysters. Chromium is not likely to accumulate in the tissues of fish and shellfish. Limited studies of air concentrations during cleanup of CCA-contaminated soil at wood- preserving sites showed that air levels of chromium(VI), arsenic and copper were below the occupational standards. Workers directly involved in the repackaging, containment or cleanup of leaking containers of CCA or of soil saturated with CCA, however, may be exposed to high levels of CCA through direct dermal contact, inhalation of aerosols or particulates and inadvertent ingestion. Few studies have been conducted on the health effects of CCA. CCA as a concentrated solution is corrosive to the skin eyes and digestive tract. Studies of workers exposed to CCA in wood-preserving plants have not found adverse health effects in these workers, but the studies involved small numbers of workers and therefore are not definitive. People exposed to very high levels of CCA, from sawing wood that still had liquid CCA in it or from living in a home contaminated with ash containing high levels of chromium(VI), arsenic and copper, experienced serious health effects including nosebleeds, digestive system pain and bleeding, itching skin, darkened urine, nervous system effects such as tingling or numbness of the hands and feet and confusion, and rashes or thickening and peeling of the skin. These health effects of the mixture are at least qualitatively reflective of the health effects of the individual components of CCA (arsenic, chromium(VI) and copper). For a given mixture, the critical effects of the individual components are of particular concern, as are any effects in common that may become significant due to additivity or interactions among the components. Effects of concern for CCA, based on the known effects of the individual components, include cancer (arsenic by the oral route, arsenic and chromium(VI) by the inhalation route), irritant or corrosive effects (all three mixture components), the unique dermal effects of arsenic, neurologic effects (arsenic and chromium(VI), and hematologic, hepatic and renal effects (all three components). Because arsenic, chromium(VI), and copper components affect some of the same target organs, they may have additive toxicity toward those organs. Few studies have investigated the potential toxic interactions among the components (arsenic, chromium(VI) and copper) of CCA. The available interaction studies and also possible mechanisms of interaction were evaluated using a weight-of-evidence approach. The conclusion is that there is no strong evidence that interactions among the components of CCA will result in a marked increase in toxicity. This conclusion reflects a lack of well designed interaction studies as well as uncertainties regarding potential mechanisms of interaction. Confidence in the conclusion is low. Workers exposed to high levels of CCA during cleanup of leaking containers of CCA or soil heavily contaminated with CCA should wear protective clothing and respirators if air concentrations of arsenic are above 10 microg/m3. In addition, they should not eat, drink or use tobacco products during exposure to CCA, and should thoroughly wash after skin contact with CCA and before eating, drinking, using tobacco products or using restrooms. When protective clothing becomes contaminated with CCA, it should be changed, and the contaminated clothing should be disposed off in a manner approved for pesticide disposal. Workers should leave all protective clothing, including work shoes and boots, at the workplace, so that CCA will not be carried into their cars and homes, which would endanger other people. People not involved in the cleanup of the CCA and who are not wearing protective clothing should be prevented from entering contaminated areas. Leaking containers of CCA must be repackaged and contained to prevent direct exposure of on-site personnel; and contaminated soil needs to be removed to prevent the CCA from leaching into surface water and groundwater, thereby contaminating sources of drinking water.
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PMID:Chemical-specific health consultation for chromated copper arsenate chemical mixture: port of Djibouti. 1842 80

The aim of the present work was to study clinical course of depression in patients (pts) with diabetes mellitus (DM) and non-proliferative retinopathy (NPR). In total, 250 pts with DM were included into the study, and more separated into 2 groups (Gr): Gr.1 (n=115)--pts with DMT1 and DMT2 without NPR; mean ABP - SBP < or = 130 mmHg/DBP < or = 85 mmHg. Fundus photography grade 10/10. Gr.2 (n=135)--was subdivided in Gr.2a (n=43), pts with DMT1; fundus photography grade from > or = 20/10 to < or = 47/47; mean ABP - SBP < or = 130 mmHg/DBP < or = 85 mmHg; Gr.2b (n=92) pts with DMT2 fundus photography grade from > or = 20/10 to < or = 47/47, mean ABP - SBP < or = 160 mmHg/DBP < or = 90 mmHg. To assess depression severity a 12-question Screening Questionnaire was used, results were compared to Beck's and Hamilton's Depression and Sheehan's Anxiety Scales. According to Sheehan's Scale pts with DMT1 most often complained of profuse sweating (66+/-16%), while in DMT2 more often itching and numbness in different parts of the body (72+/-11%) were registered. According to the Beck's scale the most frequent and acute symptoms were: depressed mood, sadness (100-10%), disappointment about their future (78+/-14%), inferiority feeling (90+/-10%), irritation (89+/-11%), feeling of being unlucky (75+/-15%), decreased working ability (78+/-14%). DMT1 was characterized by light while DMT2 by moderate depression. Thus, depression is one of the most severe DM complications; it has negative effect both on pts compliance and quality of his/her life. When DM is complicated by NPR depression takes the most sever form (psychopathologic symptoms are observed in 85.9% of cases).
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PMID:[Psychopathologic peculiarities in patients with diabetes mellitus and non-proliferative retinopathy]. 1920 20

Olfaction and nasal trigeminal chemoreception together convey an impression of the physical and chemical qualities of inspired air. "Nasal pungency" refers to the nasal trigeminal impact of inhaled air pollutants as well as spicy foods and selected medicaments. Such diverse sensations as cooling, numbness, tingling, itching, burning, and stinging are all conveyed by the trigeminal system yet are successfully differentiated in psychophysical testing, with or without concomitant olfactory information. Here we briefly review the neurobiological and psychophysical evidence for qualitative specificity in the nasal trigeminal system.
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PMID:Qualitative effects in nasal trigeminal chemoreception. 1968 37

Notalgia paresthetica is a rare nerve compression. From the Greek word noton, meaning "back," and algia, meaning "pain," "notalgia paresthetica" implies that symptoms of burning pain, itching, and/or numbness in the localized region between the spinous processes of T2 through T6 and the medial border of the scapula constitute a nerve compression syndrome. The compressed nerve is the dorsal branch of the spinal nerve. It is compressed by the paraspinous muscles and fascia against the transverse process of these spinal segments. This is the first report of symptomatic relief by decompression of this nerve.
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PMID:Surgical decompression for notalgia paresthetica: a case report. 1979 Jan 77

Alpha-herpesviruses, including human herpes simplex virus 1 & 2, varicella zoster virus and the swine pseudorabies virus (PRV), infect the peripheral nervous system of their hosts. Symptoms of infection often include itching, numbness, or pain indicative of altered neurological function. To determine if there is an in vitro electrophysiological correlate to these characteristic in vivo symptoms, we infected cultured rat sympathetic neurons with well-characterized strains of PRV known to produce virulent or attenuated symptoms in animals. Whole-cell patch clamp recordings were made at various times after infection. By 8 hours of infection with virulent PRV, action potential (AP) firing rates increased substantially and were accompanied by hyperpolarized resting membrane potentials and spikelet-like events. Coincident with the increase in AP firing rate, adjacent neurons exhibited coupled firing events, first with AP-spikelets and later with near identical resting membrane potentials and AP firing. Small fusion pores between adjacent cell bodies formed early after infection as demonstrated by transfer of the low molecular weight dye, Lucifer Yellow. Later, larger pores formed as demonstrated by transfer of high molecular weight Texas red-dextran conjugates between infected cells. Further evidence for viral-induced fusion pores was obtained by infecting neurons with a viral mutant defective for glycoprotein B, a component of the viral membrane fusion complex. These infected neurons were essentially identical to mock infected neurons: no increased AP firing, no spikelet-like events, and no electrical or dye transfer. Infection with PRV Bartha, an attenuated circuit-tracing strain delayed, but did not eliminate the increased neuronal activity and coupling events. We suggest that formation of fusion pores between infected neurons results in electrical coupling and elevated firing rates, and that these processes may contribute to the altered neural function seen in PRV-infected animals.
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PMID:Pseudorabies virus infection alters neuronal activity and connectivity in vitro. 1987 91

Morvan syndrome is a rare autoimmune disease named after the French physician Augustin Marie Morvan. It is characterized by multiple, irregular contractions of the long muscles, weakness, pruritus, hyperhidrosis, insomnia, and delirium. Here, we describe a 17-year-old young man, previously diagnosed with B-cell lymphoma, who presented with multiple asynchronous fasciculations of the long muscles of his lower extremities accompanied by numbness. The patient responded initially to pulse corticosteroids with diminution of the fasciculations. He achieved complete remission following 7 consecutive, monthly intravenous immunoglobulin injections. The present case is described in the context of the available literature.
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PMID:Morvan syndrome following B-cell lymphoma. 2011 Feb 20


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