Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
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Query: UMLS:C0033774 (
pruritus
)
14,546
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Diverse sensory neurons exhibit distinct neuronal morphologies with a variety of axon terminal arborizations subserving their functions. Because of its clinical significance, the molecular and cellular mechanisms of
itch
are being intensely studied. However, a complete analysis of
itch
-sensing terminal arborization is missing. Using an MrgprC11
CreERT2
transgenic mouse line, we labeled a small subset of
itch
-sensing neurons that express multiple
itch
-related molecules including MrgprA3, MrgprC11, histamine receptor H1, IL-31 receptor,
5-hydroxytryptamine receptor 1F
, natriuretic precursor peptide B, and neuromedin B. By combining sparse genetic labeling and whole-mount placental alkaline phosphatase histochemistry, we found that
itch
-sensing skin arbors exhibit free endings with extensive axonal branching in the superficial epidermis and large receptive fields. These results revealed the unique morphological characteristics of
itch
-sensing neurons and provide intriguing insights into the basic mechanisms of
itch
transmission.
...
PMID:Visualizing the Itch-Sensing Skin Arbors. 3309 23
