Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033774 (pruritus)
 14,546 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Scabies is an inflammatory skin disease caused by the mite Sarcoptes scabiei. The mite itself provokes little dermatitis. The rash and itch associated with scabies is probably a manifestation of immune response. The immune response may help to limit the number of infesting organisms either directly by toxic products generated during the reaction or indirectly by evoking scratch. Critical studies using purified antigens from scabies mites in vivo and in vitro will be necessary in order to clarify the nature of the antigens involved and the role of different types of immune responses in producing clinical disease.
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PMID:The immunology of scabies. 641 47

We report two cases with adverse cutaneous reactions under lithium medication for manic-depressive disease. The first patient developed follicular keratosis, psoriasiform plaques and seborrheic dermatosis, the second only sclerotic plaques. Cutaneous side-effects that have been associated with lithium therapy include: acneiform eruption, pruritus, maculopapular eruptions, folliculitis, pretibial ulcerations, alopecia...and exacerbation of psoriasis. The exact pathophysiologic mechanism by which lithium induced cutaneous pathology is not completely understood. The various physiologic actions seem to be incomplete in substitution for other extracellular and intracellular cations and interference with cyclic adenosine monophosphate mediated processes.
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PMID:[Cutaneous lesions due to lithium therapy (author's transl)]. 646 94

The scrotal dermatitis is a syndrome with itching, oedema, scales and lichenification. Those symptoms change according to the aetiology agent. In the research of mycological and bacteriological elements was found "Candida" and staphilococus as the most common agent. This aetiology agent on an abnormal skin plus the rubbing and the soaking can explain the pathogenesis of this dermatosis.
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PMID:[Dermatitis of the scrotum]. 675 Feb 72

6 patients with itching due to skin disorder and 6 student controls were studied in the sleep laboratory. It was found that some of the patients had personality characteristics consistent with Sifneos' concept of alexithymia and that these were associated with a trend towards less REM sleep and with a significant lack of involvement in dreams collected under standardised sleep laboratory conditions. It is suggested that dreams collection in a sleep laboratory may be a valuable new method in the study of the link between emotional life and psychosomatic disorders.
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PMID:Sleep, scratching and dreams in eczema. A new approach to alexithymia. 711 18

Pruritic urticarial papules and plaques of pregnancy (PUPPP) was recently defined as an intensely pruritic cutaneous eruption occurring in the third trimester. We are reporting fifteen additional cases of this distinctive eruption. The lesions began in the third trimester in all but two patients. The rash consisted of a symmetric eruption of papules, urticarial lesions, and some erythema multiforme-like target lesions. Histologic examination showed a mild nonspecific lymphohistiocytic perivasculitis. Moderate or intense pruritus was present in all but one case. The abdomen and proximal extremities were most commonly involved, but two patients had lesions only on the lower legs. Clearing occurred prior to delivery (five cases), within 1 week of delivery (nine cases), and at 6 weeks postpartum (one case). The pruritus was decreased with topical corticosteroids and diphenhydramine in all cases except one. Fetal wastage did not occur. Subsequent pregnancies were uneventful in two patients. PUPPP is a benign dermatosis of pregnancy which resolves spontaneously or with delivery.
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PMID:Pruritic urticarial papules and plaques of pregnancy (PUPPP). A clinicopathologic study. 728 54

We describe the case of a young man of Calabrian origin, who came to our observation for the appearance of erythematous pustular, intensely itching, lesions on the arms, trunk and, in a less extent, on the face. The blood count revealed a differential cell count of 16.8% eosinophils. Serum IgE levels were elevated (1000 IU/ml), and T cell subsets showed an increase in CD8+ and a decrease in CD4+ with an inversion of CD4+/CD8+ ratio (= 0.78). The result of the following investigations were either normal or negative: anti-(ds)DNA antibody, anti-nuclear antibody, anti-smooth muscle antibody, anti-striated muscle antibody, serological tests for viral, bacterial, fungal and parasitic diseases and cultural examination of the material from lesion. Histopathological examination of a biopsy specimen from the left arm showed the presence of abundant perivascular inflammatory infiltrate in the dermis and inflammatory infiltrate, with numerous eosinophils, around sebaceous glands. Taken together, all these data suggest the diagnosis of eosinophilic pustular folliculitis, a dermatosis of unknown etiology, with a histopathological picture identical to Ofuji's disease. Eosinophilic pustular folliculitis can be associated with HIV infection or haematological diseases (as non-Hodgkin lymphomas, myeloma, etc.); it was also reported in adult immunocompetent healthy individuals and in children. On the basis of our findings, we propose that this case should be classified as an idiopathic form, as we were not able to demonstrate any associated disease.
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PMID:[Eosinophilic pustular folliculitis and Ofuji disease. A case report]. 750 2

A cross-sectional survey of 770 subjects in onchocerciasis hyperendemic villages and 223 subjects from a control community in Nebbi District in the West Nile region of Uganda revealed a high prevalence of onchocercal skin disease of 48% in endemic villages. The most common skin problem was troublesome itching (40%); and the prevalent skin lesions were chronic papular onchodermatitis (16%), depigmentation (4%), lichenified onchodermatitis (2%) and acute papular onchodermatitis (1%). Other typical varieties of onchocercal skin diseases such as, hanging groin, lymphoedema and marked lymphadenopathy were infrequent, and considered rare. Pityriasis vergicolor was the most common non-onchocercal skin lesion in both control and endemic communities, accounting for 37% of all non-onchocercal skin lesions. These skin lesions were associated with a variety of psycho-social and economic impact; and there was a positive correlation between the prevalence of troublesome itching and the prevalence of modules (correlation coefficient r = 0.62, p = 0.00). Given the prospects of onchocerciasis control based on mass ivermectin distribution in communities where blindness is common, we recommend that treatment be extended to communities where blindness is less common, but skin disease known to be predominant.
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PMID:Dermatological problems of onchocerciasis in Nebbi District, Uganda. 755 85

Insect hypersensitivity is the most common cause of equine pruritus. It is a seasonal, highly pruritic dermatosis that is caused by the salivary antigens of biting insects. The most common insects are discussed in terms of the area of the horse affected, clinical signs, therapy, and preventative strategies.
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PMID:Parasitic dermatoses that cause pruritus in horses. 763 60

A randomized controlled trial compared the effectiveness of 4 group treatments for atopic dermatitis, a chronic skin disorder characterized by severe itching and eczema: dermatological educational program (DE), autogenic training as a form of relaxation therapy (AT), cognitive-behavioral treatment (BT), and the combined DE and BT treatments (DEBT). BT comprised relaxation, self-control of scratching, and stress management. Group treatments were also compared with standard medical care (SMC). Assessments at 1-year follow-up showed that the psychological treatments (AT, BT, and DEBT) led to significantly larger improvement in skin condition than intensive (DE) or standard (SMC) dermatological treatment, accompanied by significant reductions in topical steroids used. The results corroborate preliminary reports that psychological interventions are useful adjuncts to dermatological treatment in atopic dermatitis.
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PMID:Treatment of atopic dermatitis: a comparison of psychological and dermatological approaches to relapse prevention. 767 40

Many pregnancies are complicated by a pruritus. A study of the liver functions, including a determination of plasma bile acids, and a biopsy of each doubtful dermatological lesion with direct immunofluorescence allow to distinguish the specific pruritic diseases of the pregnancy: pemphigoid gestationis, papulous and pruritic dermatitis and cholestasis of pregnancy. The pemphigoid gestationis is an autoimmune bullous acquired dermatosis, which recurs at each pregnancy; a positive direct immunofluorescence is specific of the disease; the fetal prognosis seems to be good; a systemic corticotherapy is necessary. The papulous and pruritic dermatitis are the most common dermatosis during the gestation: the maternal and fetal prognosis are excellent, but this diagnosis remains a diagnosis of elimination. The cholestasis of pregnancy is characterized by an isolated pruritus which rapidly disappears in the postpartum period; its pathogeny probably includes many factors, but it seems to be favoured by a genetic ground; the determination of plasma bile acid, even if it is not specific, leads toward the diagnosis. The mother often requires an aggressive symptomatic treatment but the delivery can be delayed till the pulmonary maturity is obtained.
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PMID:[Pruritus specific to pregnancy]. 782 15


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