Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033774 (pruritus)
 14,546 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 200 patients aged 55 years and above were studied for cutaneous changes associated with ageing. The majority of patients (66%) were found to be in the age group of 55 to 64 years, of these 63% were males and 37% females. Pruritus was the commonest complaint in 78.5%. A variety of cutaneous lesions were observed. The commonest were cherry angiomas, seborrhoeic keratosis and naevus cell naevi. Not a single case of cutaneous malignancy was seen. Only 34.5% of the total dermatoses were found to be of infective aetiology. Diabetes was the most commonly associated systemic ailment. A psychosomatic background was observed in nearly 9.5% of the cases.
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PMID:A study of geriatric dermatoses. 2095 55

Inflammatory linear verrucous epidermal nevus (Ilven) is a rare variant of epidermal verrucous nevus that commonly affects females. Clinically is characterized by the appearance, since birth, of recurrent inflammatory phenomena with chronic eczematous or psoriasiform aspects, usually unilateral, with severe pruritus, and refractory to therapy.
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PMID:Case for diagnosis. Inflammatory linear verrucous epidermal nevus. 2115 5

Apocrine nevus is a rare tumor composed of increased mature apocrine glands and ductal structures within a fibrous stroma, located predominantly in the reticular dermis. They have been reported in association with apocrine carcinoma, extramammary Paget disease, and syringocystadenoma papilliferum; less commonly a pure apocrine nevus is identified, unassociated with another apocrine proliferation. Clinically apocrine nevi may appear as solitary or multiple nodules or plaques on the scalp, presternal skin, though they are seen most commonly in the axillae. We describe 4 cases of pure apocrine nevus, all of which appeared clinically as painless or mildly tender skin-colored axillary masses, 2 of which were bilateral. In each case, the lesions appeared in adulthood, and patients denied knowledge of congenital or childhood presence. Patients denied pruritis, discharge, bleeding, or antecedent trauma. Grossly, the specimens consisted of subcutaneous, multicystic ill-defined nodules. Biopsy showed prominent apocrine glands composed of irregularly columnar luminal cells with eosinophilic cytoplasm arranged in a somewhat organoid pattern filling the reticular dermis and extending into the subcutaneous adipose tissue. The glandular luminal cells displayed decapitation secretion. There was a paucity of pilosebaceous units. In one case, the overlying epidermis was papillomatous. The deepest portion of one specimen had lactational change simulating a lactational adenoma. No atypia was seen in either the glandular structures or the stroma. The adjacent sebaceous and eccrine structures were normal. The histologic features and immunohistochemical profile in relation to other apocrine lesions will be reviewed.
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PMID:Pure apocrine nevus: a report of 4 cases. 2231 89

In Europe often no clear distinction is made between deodorant and antiperspirant. Particularly in Germany, the labeling "deo" is used for both. Only antiperspirants are capable of influencing the activity of eccrine sweat glands. In the treatment of focal hyperhidrosis, the use of aluminum chloride solutions represents the first choice. The efficacy is well documented in a variety of studies. Subjective side effects include pruritus and - less often - irritant dermatitis, which can be treated symptomatically and usually does not require discontinuation of the treatment. Rare variants of focal hyperhidrosis like auriculotemporal syndrome, Ross syndrome and nevus sudoriferus also are suitable for treatment with topical aluminum chloride hexahydrate solutions.
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PMID:[Antiperspirants for the therapy of focal hyperhidrosis]. 2265 80

Multiple, pigmented, verrucous, cutaneous lesions in a 2-year-old female cat were pathologically examined. The lesions were linearly arranged on the right side of the body, and had developed along with moderate pruritus since infancy. Histologically, prominent exophytic, papillomatous outgrowths of the epidermis and acanthosis with intense ortho and parakeratotic hyperkeratosis were characteristic of the lesions. Dermal inflammation with mononuclear cells, neutrophils, and eosinophils was also noted. Inclusion bodies, cellular degeneration, and intranuclear viral particles suggesting papillomavirus infection in the keratinocytes were not observed. Papillomavirus antigen and DNA were not detected in the lesions by immunohistochemistry and polymerase chain reaction, respectively. In accordance with these clinical and histopathological features, the cutaneous lesions of the present cat were diagnosed as epidermal nevi, which were consistent with human inflammatory linear verrucous epidermal nevi.
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PMID:Feline epidermal nevi resembling human inflammatory linear verrucous epidermal nevus. 2267 41

CME EDUCATIONAL OBJECTIVES: 1.Understand the clinical presentation of a Becker nevus.2.Describe the differential diagnosis for Becker nevus.3.Be able to discuss the appropriate management for a Becker nevus. A 9-year-old healthy male presented to the dermatology clinic for evaluation of lesions on his chest. The lesions were unilateral and had been present for at least 1 year. No lesion had been previously noted in the affected area. No treatments had been tried prior to presentation. The patient denied pruritus or pain. Review of systems, medical history, and family history were unremarkable.
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PMID:A 9-year-old boy with a hyper-pigmented patch on the right chest. 2331 19

Melanoma is rare in childhood, but from the teens onwards, the incidence steadily rises with age. Exposure to ultraviolet light radiation is the main risk factor for developing melanoma. The first sign of a melanoma is usually an unusual looking freckle or mole. It may have a variety of colours including tan, dark brown, black, blue, red, light grey, or occasionally may lack pigment. Some melanomas are itchy or tender, and more advanced lesions may bleed easily or crust over. The British Association of Dermatologists suggests referring: a new mole appearing after the onset of puberty, or a long-standing mole, which is changing shape, colour or size; any mole which has three or more colours or has lost its symmetry; a mole which is itching or bleeding; or any new persistent skin lesion especially if it is growing, pigmented or vascular in appearance, and if the diagnosis is not clear. A new pigmented line in a nail, especially where there is associated damage to the nail, or a lesion growing under a nail should also be referred. Lesions which have a high index of suspicion for melanoma should not be removed in primary care. Patients should be referred urgently to secondary care with a history recording the duration of the lesion, change in size, colour, shape and symptoms.
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PMID:GPs have role in early detection of melanoma. 2390 86

Sorafenib is a multikinase inhibitor FDA-approved for the treatment of advanced renal cell and hepatocellular carcinoma. Dermatologic side effects include hand-foot skin reaction, facial and scalp erythema and desquamation, splinter subungual hemorrhages, alopecia, pruritus, xerosis, keratoacanthomas, and squamous cell carcinomas. We report sudden eruption of melanocytic nevi diffusely in a patient receiving sorafenib.
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PMID:Sorafenib induced eruptive melanocytic lesions. 2401 Dec 81

Nevus of Ota is a unilateral, asymptomatic cutaneous and mucosal hyperpigmentation of the face that is congenital or may appear during childhood. We present a case of symptomatic acquired nevus of Ota in an adult, associated with intense pruritus, not described in the literature so far. A 32-year-old woman presented with brownish mottled macules which appeared on her face progressively over 8 days, following the distribution of the first and second divisions of the left trigeminal nerve and partially covering the iris and sclera of the left eye. She reported an intense pruritus in this area. We performed a biopsy on the left forehead, which confirmed the diagnosis of nevus of Ota. Specific stains and immunohistochemistry revealed increased numbers of mast cells. Ophthalmological tests showed acute acquired melanocytosis of the left iris and sclera. The origin of the nevus is still unclear. Several hypotheses suggest a reactivation of melanocytes during their migration from the neural crest. The pruritus reported in our patient may be explained by the increased quantity of mast cells observed in the lesion and/or neuronal stimulation of the ophthalmic and maxillary divisions of the fifth cranial nerve.
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PMID:Pruritic acquired nevus of Ota. 2406 Jul 4

Inflammatory linear verrucous epidermal nevus (ILVEN) is a pruritic, erythematous scaly epidermal nevus which follows a Blaschko's lines. Lichen striatus, linear Darier disease, linear porokeratosis, linear lichen planus, linear psoriasis, and the verrucous stage of incontinentia pigmenti may all have similar clinical presentations as the linear verrucous epidermal nevus. ILVEN can be distinguished from true nevoid psoriasis by pruritus and lack of response to antipsoriatic treatments. Various therapeutic modalities have been described, but no one therapy has been successful consistently. Though giant ILVEN is a relative contraindication to surgical excision, here we report a case showing effectiveness of full thickness excision and skin grafting for this condition.
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PMID:Giant inflammatory linear verrucous epidermal nevus: successfully treated with full thickness excision and skin grafting. 2424 99


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