Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033774 (pruritus)
 14,546 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The inflammatory linear verrucous nevus is a recently described variety of epidermal nevus clinically and histologically characterized by an inflammatory component. The lesion stars at birth or at early age, pruritus is constant. Histologically the picture is psoriasiform. The therapeutic response is poor. Seven cases are presented. Associated extracutaneous alterations were presented in four of them.
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PMID:[Inflammatory linear verrucous epidermal nevus. Clinical and histopathological aspects of 7 cases]. 39 30

The clinical and histological features of 13 malignant melanomas in children less than 13 years of age in New South Wales, Australia, were compared with those in a control group of children with 15 Spitz nevi, 4 of which were considered atypical, and 2 unusual compound nevocellular nevi. Six of the controls had been previously diagnosed histologically as malignant melanoma. The objective observations made by one or more histopathologists experienced in reporting melanocytic lesions, and the clinical details, mainly from the Sydney Melanoma Unit files, were entered on a detailed protocol. Evaluation was assisted by the use of SPSS-X software on a mainframe VAX computer. Six of the 13 children with malignant melanoma died with their disease. The most frequent clinical features found in the malignant melanomas were bleeding, ulceration, itching, and black or variegated color. Recent enlargement and darkening were noted in the majority of both the malignant melanomas and the Spitz nevi. Histological features favoring malignancy in this series were mitoses within 0.25 mm of the dermal margin of the melanoma, a dermal mitotic rate exceeding 2/mm2, ulceration, surface exudate, large pigment granules, and clear-cell differentiation. The median thickness of the malignant melanomas was 1.3 mm but in the 4 children who died with melanoma the median thickness was 2.9 mm. Absence of mitoses, predominance of spindle cells, and diffuse maturation favored Spitz nevus. The median thickness of the Spitz nevi was 0.7 mm.
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PMID:Malignant melanoma in childhood: a clinicopathologic study of 13 cases and comparison with Spitz nevi. 156 97

In the absence of more effective treatment for advanced tumors, early diagnosis and treatment of localized tumors is the most effective way of reducing the burden of illness associated with melanoma. This study examined the following factors: prevalence of signs of melanoma (a mole changing in size, shape, appearance, or color, itching or tingling, bleeding or weeping, becoming raised) in 1344 individuals in a randomly selected sample of 1075 households; the length of delay in seeking medical advice; the factors associated with either going to a medical practitioner or not going/delaying; and the actions of the medical practitioners when first presented with these signs. The results indicate that a large proportion of the sample (11.9%, n = 156) had observed signs of melanoma in the previous 12 months. Of the sample reporting signs that had first appeared in the previous 5 years, only 32% sought medical advice about the signs within the recommended period. Of the sample either not seeking advice at all or delaying, 49% reported that they thought the sign "wasn't serious/would clear up." Furthermore, 30% of the sample either did not known or underrated the importance of early detection and treatment of lesions. These results indicate that there is a deficit in the knowledge of the general public about the signs of melanoma, the severity of the disease, and the possible risks associated with delay.
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PMID:A community study of delay in presenting with signs of melanoma to medical practitioners. 173 10

Anamnestic data of 668 patients suffering from malignant melanoma were statistically evaluated. More than half of the patients had noticed a "mole" at the site where the melanoma was subsequently found. More than a third of the patients guessed that this mole had always been there, and an additional 15% were of the opinion that the mole had been present since childhood. About a third of the patients stated that the lesion had existed for more than 20 years. About 45% of them had been aware of it for between one and 20 years. Only 21.5% had not noticed any pigmented spot until less than one year before the diagnosis of melanoma. From the data, we conclude that in about 35% of the cases the pigmented area had first been noticed before puberty; in 49% of the cases, the lesion had not been observed until the patient's 36th year of age. Once the patients became aware of the growing development of the mole, 62% of them sought medical advice within one year. The other patients waited longer, 8.7% of them even more than 5 years, before having it removed. In the majority of the cases, the patients' attention was drawn to the malignant growth by changes in size and thickness. In 40% of the cases, changes in color were noted. The "classic" signs of alarm such as itching and bleeding were reported in 29.2% and 34.9% of the cases, respectively.
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PMID:[Growth dynamics and histogenesis of malignant melanomas based on anamnestic data]. 340 62

A 12-year-old white boy presented with symmetrically appearing papular, nodular, comedo-like, highly itching lesions involving the skin on his ankles. They had first appeared 3 years earlier. Numerous cutaneous biopsies showed tumoral buds of basalioma cells associated with follicular structures, infundibular cysts and also hypertrophy and hyperplasia of sebaceous glands. To the best of our knowledge, there are no reported cases with the same clinical and histopathological findings as in those reported here. We believe the lesions represent a "bilateral follicular basal cell nevus with comedones".
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PMID:Bilateral follicular basal cell nevus with comedo-like lesions. 619 99

We report our experience in Singapore with the use of the new oral Retinoid-etretinate (Tigason RO 10-9359) in 23 patients suffering from various congenital disorders of keratinisation. In this study the drug was administered to 8 patients with Darier's disease, 7 patients with congenital ichthyosis, 4 patients with palmar plantar keratoderma, 2 patients with systematised epidermal naevus and 2 patients with progressive symmetrical erythrokeratoderma. The best results were obtained in patients with ichthyosis where complete clearance was possible. All patients with Darier's except one showed significant improvement. Palmar plantar keratoderma except for one patient gave only fair to minimal improvement. Etretinate was useful in systematised epidermal naevus and progressive symmetrical erythrokeratoderma. Pruritus and cheilitis were the commonest side effect. In two patients (both with Darier's disease) treatment was stopped because of side effects. The side effects were dose related. The histology showed a reduction of the keratin layer but remnants of the original features of the pathology were still present.
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PMID:Oral retinoid (Tigason R etretinate) therapy in congenital disorders of keratinisation. 622 85

Due to the recent increase of incidence of malignant melanoma and due to the significance of early detection for a definite cure from the disease, diagnosis and differential diagnosis of malignant melanoma are very important. At first glance the malignant potential of a pigmented mole can be evaluated by the macroscopical ABCD rule (Asymmetry, irregular Border, different Colors, and Diameter larger than 6 mm). In addition, also the history of the patient might be helpful. Thus a malignant melanoma should be considered when a patient reports a new rapidly growing pigmented lesion or a change in an existing mole in color, size, shape, and surface. Itching or burning should also arouse the suspicion of malignant change. Risk factors for the development of a malignant melanmoma are a high number of benign melanocytic nevi, large congenital melanocytic nevi, fair skin types with a tendency to sunburns and a malignant melanoma in the family of the patient. With dermatoscopy, which is skin surface microscopy at 10x magnification, the difficult macroscopical differential diagnosis is facilitated, because this technique opens a new dimension between macroscopy and microscopy.
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PMID:[Classification, diagnosis and differential diagnosis of malignant melanoma]. 819 99

The clinical and histopathological findings in a case of inflammatory linear verrucose epidermal nevus coexisting with lichen amyloidosus are presented. A 33-year-old woman had had linear verrucose lesions which were histopathologically compatible with ILVEN, and with which no amyloid deposits were associated, on her left lower leg for 30 years. She had noticed keratotic papules around the verrucose lesions on the left leg for the last 3 years. Histopathology of these papules revealed amyloid deposits in the upper dermis under the hyperkeratotic and acanthotic epidermis. Topical application of DMSO liniment with dexamethasone successfully treated the ILVEN. This remission of both lesions and itching also alleviated the keratotic papules on the left leg.
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PMID:Inflammatory linear verrucose epidermal nevus coexisting with lichen amyloidosus. 870 55

Vulvar melanomas are seen in about 3% of all melanomas. The percentage reaches 10% of all malignant tumors of the vulva. The mean age of the patients is approximately 55 years. The first symptoms noticed by the patients are bleeding, pruritus, or a mass in the groin. Vulvar melanomas are mostly located at the labia minora. The differential diagnosis comprises different pigmented lesions, such as seborrheic keratosis, nevocellular nevus, lentigo, or hyperpigmentations of different origin. There is no typical histopathological pattern, but mostly melanomas of this site are of the mucosal-lentiginous type. As treatment modalities, most investigators propose a complete excision for melanomas thinner than 1 mm, and for thicker melanomas a wide excision. Recent investigations have shown that hemivulvectomies or vulvectomies do not show a better survival. The question of a prophylactic ipsilateral lymph node dissection is not answered yet. The survival rates depend on the tumor thickness and/or the infiltration level. The importance of an early diagnosis should be stressed in vulvar melanomas, especially through an accurate inspection of the vulva at the time of a genital examination. In addition, vulvar self examinations are an excellent possibility for early diagnosis. This allows a definite treatment and vulvar conservation.
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PMID:Vulvar melanoma. 872 27

The purpose of this study was to evaluate the frequency of skin changes among 100 patients from the Hepatogastroenterology Department of the University Hospital, Strasbourg, France who were hepatitis C virus-positive (HCV) and HIV-negative. Their clinical data were compared to those of 50 HCV-, and HIV-negative patients from the same Department, who suffered from various liver diseases. Psoriasis, rosacea, seborrheic dermatitis, cherry angiomas, spider nevus and skin cancers were noted in similar proportions in the two groups. In 15% of HCV-positive patients vs. 4% of controls, chronic pruritus was noted (p < 0.05). In 9 HCV-positive patients, pruritus was not related to itching dermatosis, and only 2 of these patients had mild cholestasis. Four cases of lichen planus vs. 0 in the control group were recorded. The virological data of patients with pruritus or lichen planus were not different than those of the rest of the group. Our findings indicate that systematic skin check-up in HCV-positive patients is valuable.
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PMID:Systematic cutaneous examination in hepatitis C virus infected patients. 977 54


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