Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033774 (pruritus)
 14,546 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A patient (E.M.) with marked eosinophilia and hyperimmunoglobulin E (IgE) has been followed for 4 years. Peripheral blood eosinophilia reached levels in excess of 18,000 cells/mm3 and serum IgE concentration increased to more than 210,000 units/ml (about 0.48 mg IgE/ml). The IgE has both lambda and kappa light chains and is therefore considered polyclonal. The patient has an increase in peripheral blood lymphocytes which stain for surface IgE. Transfer of the patient's plasma (plasmsEM) to a rhesus monkey did not induce peripheral boood eosinophilia. The half life of IgEEM in a rhesus monkey was 2.2 days, which is similar to the half life of myeloma IgE in human subjects. The condition was not associated with defined morbidity except for mild persistent pruritus. Various studies revealed no evidence for atopic parasitic, immune deficiency or neoplastic disease.
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PMID:Massive polyclonal hyperimmunoglobulinemia E, eosinophilia and increased IgE-bearing lymphocytes. 4 11

A double-blind crossover study of the efficacy of disodium cromoglycate given by mouth to control the cutaneous, gastrointestinal and central-nervous-system manifestations of systemic mastocytosis was carried out in five patients for periods of eight to 32 months. In 15 of 18 trials, disodium cromoglycate produced marked amelioration of the clinical manifestations of pruritus, whealing, flushing, diarrhea, abdominal pain and disorders of cognitive function. By contrast, in all 19 trials with placebo, there was no improvement in these symptoms and signs. Histaminuria and peripheral-blood eosinophilia were unrelated to disease activity and were unaffected by drug therapy. Although it is poorly absorbed after administration by mouth, disodium cromoglycate is of clinical benefit to patients with systemic mastocytosis.
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PMID:Oral disodium cromoglycate in the treatment of systemic mastocytosis. 11 Nov 24

A discussion is presented on the epidemiological and clinical aspects of filariasis in persons returning from tropical countries. In our population filariasis is mainly imported from central and western Africa, especially Cameroon. Missionaries and voluntary workers spending periods of years in the tropics are particularly exposed. About 50% of the patients are normal on clinical examination and 40% do not even evidence symptoms due to the low parasite density. Therefore, demonstration of the parasite, which is the diagnostic aim, is often very difficult and requires special techniques. Whenever parasite demonstration is impossible, itching, eosinophilia and a positive immunofluorescence reaction are important diagnostic signs, but they may occasionally develop years after the subject's return. Treatment is by diethylcarbamazine and suramine; their administration and side effects are described and 2 cases involving severe reactions due to inadequate treatment are cited.
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PMID:[Filariasis in patients returned from the tropics. Studies on 64 cases]. 13 46

Animals were experimentally infested with Sarcoptes scabiei var suis at weekly intervals between birth and five weeks of age. Excoriations were observed on the luminal surface of the ear seven days after the initial infestation. Encrusted lesions developed in the ears of all pigs between the third and eighth weeks but spontaneously regressed and disappeared by the 14th week. A generalised pruritus, accompanied by focal erythematous skin lesions developed in a majority of pigs between seven and 11 weeks of age. The presence of pruritus was associated with an eosinophilia and histological changes in the skin which were consistent with an allergic reaction. The results are discussed in relation to their diagnostic significance and their importance in the control and eradication of the disease.
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PMID:Experimental Sarcoptes scabiei infestation in pigs: (1) pathogenesis. 43 1

Clinically apparent pancreatic disease due to sarcoidosis has not been described in typical sarcoid patients. A few cases have been described at exploratory laparotomy and pancreatic involvement in autopsied cases is more common than generally appreciated. We report a patient not previously known to have sarcoidosis whose presentation with pruritus, eosinophilia and cholestatic serum chemistry suggested a reaction to phenothiazines. The correct diagnosis was made during surgery for an asymptomatic gallstone. No other evidence of pancreatic disease has become apparent during follow-ups of two years.
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PMID:Granuloma (sarcoid?) of the pancreas. A case report. 66 51

A man who was suffering from recurrent staphylococcal infection had antecedent symptoms of severe pruritus. Laboratory investigations showed leukocytosis with eosinophilia, hyperimmunoglobulinemia of all fractions, but particularly of IgE, and a deficiency of cell-mediated immunity on in vivo testing. Phagocytosis and bactericidal activity of polymorphonuclear leukocytes were normal, but a cellular and serum-associated defect in leukocytotaxia was present. Ultrastructural changes were observed in polymorphonuclear leukocytes. Association of impaired leukocytotaxia and elevated levels of IgE is not uncommon. Recurrent bacterial infections in the patient described are probably related to defective chemotaxis.
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PMID:Defective leukocytotaxia and recurrent staphylococcal infecion: deficiency of leukocytotaxia and abnormal granulocytes associated with increase serum IgE levels in an adult with recurrent staphylococcal infection. 68 54

Immunoblastic lymphadenopathy was first described in the german literature in 1975 by Lennert as "Lymphogranulomatosis X." The disease is characterized by generalized lymphadenopathy, hepatosplenomegaly, dysproteinemia, fever and hyperergic reactions such as pruritus, skin rush and eosinophilia. The first ORL occurrence of the disease in Waldeyer's ring and cervical lymph nodes is reported. The histologic picture is characterized by a vascular proliferation with immunoblasts, plasma cells and interstitial amorphous acidophilic material but without Sternberg cells. The origin of the disease from primary malignant neoplasia or hyperergic reactions has not yet been defined. Although prognosis is uncertain and therapy limited, the best management involves small doses of corticoids, supplemented by antibiotics.
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PMID:[Head and neck manifestations of lymphogranulomatosis X (author's transl)]. 70 Nov 5

Sweet itch is an intensely pruritic dermatitis of horses recurring annually in Ireland from April to November. The tissue changes of sweet itch have similarities to immediate-type hypersensitivity reactions which occur in skin sensitised to the saliva of bloodsucking insects. There was subepidermal oedema, and marked eosinophilia; the blood vessels were tortuous and enlarged. Microfilaria were not found in serial sections of lesions of 5 affected horses. The histopathology of the immediate dermal remal reaction to the intradermal injection of Culicoides extract shows dermal vasodilation and eosinophil diapedesis. Seven horses challenged intradermally with whole extract of Culicoides, Stomoxys calcitrans, Tabanidae and saline, gave immediate reactions to Culicoides, 3 gave immediate reactions to Stomoxys calcitrans. Immediate and delayed reactions only occurred at the sites of challenge with Culicoides extract. Three normal ponies when challenged intradermally with extracts of biting flies, showed minimal dermal reactions.
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PMID:A report on clinical aspects and histopathology of sweet itch. 73 65

A 41-year-old man developed intense itching without visible cutaneous changes, epigastric pressure pain, and a slight intolerance to alcohol. He was found to have persistent blood eosinophilia. The eosinophil granulocytes were of abnormal appearance in the light microscope: larger than normal, the nuclei were multilobulated (4-6 lobes), the cytoplasm contained atypical, large granules, ample glycogen, and up to 12 vacuoles. In the electron microscope too the eosinophil granules were entirely atypical, having an electron-dense matrix, often with a light central inclusion body which was inhomogeneous, having longitudinally oriented structures with a periodicity of about 10 nm. These findings are quite contrary to normal eosinophil granules. Enzymic studies of cytoplasmic enzymes from the granulocytes revealed a greatly reduced content of eosinophil cationic proteins, whereas 5 (7) other enzymes were present in a normal or slightly reduced quantity. The phagocytic capacity of the eosinophils against latex particles was normal. The patient developed generalized lymphomas, histologically very malignant, of the convoluted, acid phosphatase positive cell type (T-cell lymphoma). Sub-population studies of lymphocytes from a lymph node revealed 58% TE cells, while the remainder were B cells. At death, 3-1/2 years after the onset of symptoms, severe endomyocardial fibrosis was found. The thymus could not be identified. It is concluded that lymphomas should be described on the bais of clinical, histological, and histochemical criteria as well as studies of lymphocyte sub-populations and that the highly unusual eosinophil granulocytes still deserve particular attention. The endocardial fibrosis is assumed to have been due to substances liberated from the eosinophil cells.
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PMID:Unique eosinophil granules in a case of T-cell lymphoma. 89 57

The case is presented of a woman, who for seven years had vesicobullous outbreaks, typical of Dermatitis herpetiformis, with an extraordinary itching. The first biopsy had a doub acantholysis but the following one showed: "eccematoid-like spongiosis with eosinophilia" and "subepidermal bulla with eosinophilia, erythema multiformislike". The evolution of the case was to pemphigus foliaceus, and by the action of long-standing corthicotherapy ended in a typical Senear-Usher with present good health. These anomalous cases, first described clinically by Brocq, and histologically by Unna et Leredde, are best known now as "Pemphigus herpetiformis" (Jablonska et al.).
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PMID:[Herpetiforme pemphigus]. 103 84


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