Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0033774 (pruritus)
 14,546 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Occupational diseases of the skin have been detected in 19.6% of 352 workers engaged in molybdenum production. These diseases are characterized by a relatively low incidence on the dermatitis transformation into eczema and a considerable length of this process, by weak skin reactions to molybdenum tests (with 20% aqueous solution of ammonium paramolybdate), by the predominance of skin itching in the clinical picture, by a secondary pyococcic infection, and by frequent combination of eczema with allergic involvement of the ENT organs. Experimental and clinical immunologic studies have revealed that mostly humoral immune mechanisms with a relatively weak involvement of the T-lymphocytes contribute to the pathogenesis of the dermatoses due to molybdenum exposure; this fact is responsible for poor clinical manifestation of the delayed type hypersensitivity reactions and at the same time a manifest IgE-dependent pattern of allergic reactions. A clear-cut correlation between the frequency of the dermatoses and molybdenum level in environmental dust was detected, as were a considerable molybdenum contamination of the skin and the fact that hot and humid microclimate are conducive to the development of dermatoses. Basing on the results of these studies, the authors have developed recommendations on the diagnosis and prevention of molybdenum-induced dermatoses.
 ...
PMID:[Clinico-immunologic characteristics and prevention of occupational allergic dermatoses due to molybdenum exposure]. 253 14

Discussed is a 38-year-old woman, whose chief complaints were an eczema-like lesion and itching of the nipple in the left breast. Thus, Paget's disease was suspected, and touch cytology and a cytological biopsy of an aspirated specimen were done. The results indicated a class II and class V status, respectively. A radical mastectomy, therefore, was performed immediately. Macroscopic findings of the resected tissue showed no tumor in the nipple or in the mammary gland. A histological examination led to the determination of a scirrhous carcinoma of the nipple. Seventeen months after the operation, the patient has had no recurrence.
 ...
PMID:[A scirrhous carcinoma of the nipple suspected of being Paget's disease]. 253 34

The causes of vaginal discharge for pruritus vulvae in a patient are considered in three categories: common causes like vaginal candidosis, Trichomonal vaginitis, Gardnerella vaginitis; less common causes like gonococcal infection, Chlamydia infection and T-mycoplasma infection; and uncommon causes which include allergy to nylon underwear, human papilloma infection and eczema. The clinical features of each and a suggested treatment regime are given.
 ...
PMID:Investigation and treatment of vaginal discharge and pruritus vulvae. 261 1

In a group of 535 children and 103 adult patients with atopic dermatitis no differences were observed between persons with normal and raised IgE level with respect to incidence of lesions in the first or the first three months of life, the total number of the positive RAST results and the most intense reactions, that is 4 degrees, the percent of helper and suppressor T-cells, duration of remission, darkening of lower eyelids, cheilitis, involvement of the hands, the feet, the elbow flexures or knee flexures. On the other hand, in individuals with raised IgE level, especially in patients with IgE level tenfold higher or more than normal, the co-existence of alergic diseases of the respiratory system, the appearance of itching after sweating, itching after emotion, pityriasis alba, and eczema of breasts were
 ...
PMID:[Atopic dermatitis in patients with normal and raised IgE levels]. 262 28

Gamma-linolenic acid in the form of a particular variety of evening primrose oil (Epogam) has been reported of value in the treatment of atopic eczema. Nine controlled trials of evening primrose oil were performed in eight centres. Four of the trials were parallel and five cross-over. Doctors and patients assessed the severity of eczema by scoring measures of inflammation, dryness, scaliness, pruritus and overall skin involvement. Individual symptom scores were combined to give a single global score at each assessment point. In the analysis of the parallel studies, both patient and doctor scores showed a highly significant improvement over baseline (P less than 0.0001) due to Epogam: for both scores the effect of Epogam was significantly better than placebo. Similar results were obtained on analysis of the cross-over trials, but in this case the difference between Epogam and placebo in the doctors' global score, although in favour of Epogam, failed to reach significance. The effects on itch were particularly striking. There was no placebo response to this symptom, whereas there was a substantial and highly significant response to Epogam (P less than 0.0001). When the improvements, or otherwise, in clinical condition were related to changes in plasma levels of dihomogammalinolenic and arachidoni acids, it was found that there was a positive correlation between an improvement in clinical score and a rise in the fatty acid levels.
 ...
PMID:Meta-analysis of placebo-controlled studies of the efficacy of Epogam in the treatment of atopic eczema. Relationship between plasma essential fatty acid changes and clinical response. 266 20

The authors assess the clinical efficacy of sibicort, and ointment manufactured by Orion, Finland, used in therapy of patients suffering from neurodermatitis, eczema, and allergic dermatitis. Pathogenetic treatment combined with sibicort has been administered to 64 patients with disseminated true eczema, 115 ones with diffuse neurodermatitis, and 20 ones with allergic dermatitis. The ointment has been applied to and a little bit rubbed in the foci of lesions twice a day. Sibicort has proved to be a highly effective external drug for the treatment of allergic itching dermatoses. Both immediate and late results have been the best in neurodermatitis patients. No side effects or complications associated with this ointment application have been observed; the drug has been well tolerated.
 ...
PMID:[The use of sibicort in the combined therapy of patients with eczema, neurodermatitis and allergic dermatitis]. 272 10

The intensive morbidity index in respect of allergic dermatoses has made up 12.07 in 1986, allergic dermatitis being the most prevalent (72%). The morbidity has been the highest among subjects aged 21 to 40. Seasonal changes in the allergic dermatoses incidence rates have been determined: skin itching, urticaria, and neurodermatitis have been the most prevalent in October, whereas eczema occurred mostly in May.
 ...
PMID:[Morbidity from allergic dermatoses and pruritus in Blagoveshchensk]. 276 8

The contribution of secondary infection to severity and tendency to relapse in atopic dermatitis during childhood has been assessed. A total of 57 children aged between 4 months and 14 years were followed for an average of 4.73 months. A secondary infection was diagnosed in 22 (31.4%) of 70 relapses, since the lesions only subsided with antibiotics active on the bacteria isolated from the skin, usually a coagulase-positive Staphylococcus aureus. The eczema was more severe at presentation and hypogammaglobulinemia G more often found in those children who were more susceptible to secondary infections. The hypogammaglobulinemia G was present in 13 out of the 57 patients, but it normalized with age and was not correlated with IgE levels. In the children in whom the relapse or the worsening of the eczema could be attributed to secondary infection because of the positive response to the antibiotic treatment, the lesions had the appearance of pustules or showed more exudation, although in some cases only the worsening of the erythema and itching was observed. A secondary bacterial infection should be considered a likely cause of relapse or worsening of atopic dermatitis. Furthermore it may be that, at least in first year of life, hypogammaglobulinemia G is part of an immunologic impairment of atopic dermatitis which favors the susceptibility to secondary infections.
 ...
PMID:The effect of bacterial infection in the worsening of atopic dermatitis: correlations with humoral immunologic patterns. 276 15

Preparations containing urea were found to be effective in the treatment of ichthyosis vulgaris and so we were encouraged to test their use in other dry skin conditions. Urea creams are well applied to dry skin which is not inflamed. In the treatment of psoriasis, which requires a stronger water-binding substance, a combination of sodium chloride and urea in equal concentrations is optimal. Urea creams can be used in the prophylactic treatment of hand eczema and also as a prophylactic against infection, but not in the treatment of already existing infections. In psoriasis and ichthyosis urea is effective in creams substitution therapy. Though urea creams provided relief from itching in neurodermatitis, their use after treatment of eczema with fat-containing salves caused burning sensations. In our experience creams with a urea concentration of 5%-10% offer possibility for treating dry skin.
 ...
PMID:[Urea as a single drug in dry skin]. 280 24

Anti-hypertensive drugs, including diuretics and beta-blocking drugs, belong to a group of therapeutics used by about a fourth of the Danish population. As with cytostatics, antibiotics, and topical remedies, they rather frequently cause adverse drug reactions (ADR) in the skin. No exact statistical information is available concerning the extent of such side effects. The information obtained by Danish National Board of Health's Committee on Adverse Drug Reactions shows that 10-60% of ADR from diuretics, beta-blocking agents, and anti-hypertensive drugs are dermatological. The skin symptoms are not unique for any specific drug. But certain symptoms occur more frequently than others. Thiazides can give vasculitis, a phototoxic/-allergic eruption, erythema multiforme, or eczema. The combination of amiloride (5 mg) and hydrochlorothiazide (50 mg) carries the highest number of recorded ADR; 59% of these are in the skin. Half of the skin ADR are phototoxic eczema. Furosemide may give eczema, purpura, a bullous eruption, or Steven-Johnson's syndrome in rare cases. Methyldopa can induce eczematous eruptions on hands and feet, a lichenoid eruption, a lupus erythematosus-like eruption, or purpura. Hydralazine may give lupus erythematosus-like eruptions, eczema, or urticaria. Non-specific beta-blocking drugs can induce a morbilliform rash and may aggravate psoriasis. Captopril may induce pruritus in up to 15% of the patients and skin eruptions in 2%. The most serious dermatological side effect, exfoliative dermatitis, is very rarely seen following the use of anti-hypertensive drugs or diuretics.
 ...
PMID:Adverse reactions in the skin from anti-hypertensive drugs. 289 92


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>