Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033774 (pruritus)
 14,546 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a group of 535 children and 103 adult patients with atopic dermatitis no differences were observed between persons with normal and raised IgE level with respect to incidence of lesions in the first or the first three months of life, the total number of the positive RAST results and the most intense reactions, that is 4 degrees, the percent of helper and suppressor T-cells, duration of remission, darkening of lower eyelids, cheilitis, involvement of the hands, the feet, the elbow flexures or knee flexures. On the other hand, in individuals with raised IgE level, especially in patients with IgE level tenfold higher or more than normal, the co-existence of alergic diseases of the respiratory system, the appearance of itching after sweating, itching after emotion, pityriasis alba, and eczema of breasts were
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PMID:[Atopic dermatitis in patients with normal and raised IgE levels]. 262 28

The effects of dietary supplement with n-3 fatty acids to patients with atopic dermatitis were investigated in a 12-week, prospective, double-blind study. The experimental group received daily 10 g of fish oil, containing 3 g n-3 fatty acids, of which eicosapentaenoic acid represented about 1.8 g. The controls received an isoenergetic placebo supplement containing olive oil. Compliance was monitored by gas chromatographic analysis of fatty acid pattern in serum phospholipids. Results favoured the experimental group with regard to scale (P less than 0.05), itch (P less than 0.05) and overall subjective severity (P less than 0.02) as compared to the controls.
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PMID:Effect of n-3 fatty acid supplement to patients with atopic dermatitis. 265 Jun 95

A double-blind comparative study was performed to investigate the usefulness of ketotifen syrup as compared with clemastine syrup in 284 patients with atopic dermatitis. The clinical efficacy of ketotifen was significantly superior to that of clemastine. Ketotifen alleviated not only pruritus but also other dermatologic symptoms.
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PMID:Clinical evaluation of ketotifen syrup on atopic dermatitis: a comparative multicenter double-blind study of ketotifen and clemastine. 266 Jun 32

Gamma-linolenic acid in the form of a particular variety of evening primrose oil (Epogam) has been reported of value in the treatment of atopic eczema. Nine controlled trials of evening primrose oil were performed in eight centres. Four of the trials were parallel and five cross-over. Doctors and patients assessed the severity of eczema by scoring measures of inflammation, dryness, scaliness, pruritus and overall skin involvement. Individual symptom scores were combined to give a single global score at each assessment point. In the analysis of the parallel studies, both patient and doctor scores showed a highly significant improvement over baseline (P less than 0.0001) due to Epogam: for both scores the effect of Epogam was significantly better than placebo. Similar results were obtained on analysis of the cross-over trials, but in this case the difference between Epogam and placebo in the doctors' global score, although in favour of Epogam, failed to reach significance. The effects on itch were particularly striking. There was no placebo response to this symptom, whereas there was a substantial and highly significant response to Epogam (P less than 0.0001). When the improvements, or otherwise, in clinical condition were related to changes in plasma levels of dihomogammalinolenic and arachidoni acids, it was found that there was a positive correlation between an improvement in clinical score and a rise in the fatty acid levels.
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PMID:Meta-analysis of placebo-controlled studies of the efficacy of Epogam in the treatment of atopic eczema. Relationship between plasma essential fatty acid changes and clinical response. 266 20

Atmoknesis, itching provoked by open exposure of the skin to air after undressing, is a common and distressing symptom. It occurs in many patients with psoriasis and atopic dermatitis, and in elderly patients with aquagenic pruritus. It also occurs in some patients with underlying systemic causes of generalized pruritus, such as hepatobiliary disease. It does not seem to be an important feature of certain other pruritic skin diseases such as dermatitis herpetiformis and bullous pemphigoid.
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PMID:Nonrashes. 5. Atmoknesis: pruritus provoked by contact with air. 266 1

Itch sensations and skin reactions induced by histamine iontophoresis at six different current intensities were studied in 27 atopic dermatitis (AD) patients and 20 healthy controls. Subjective itch ratings were assessed on a visual analogue scale (VAS) for 8-min periods after 10-sec histamine application, while changes of skin blood flow were simultaneously measured using two Laser Doppler flowmeters. Ten minutes after each histamine application, the areas of wheal and flare reactions were planimetrically evaluated. When no or weak current was applied, AD patients revealed stronger wheal and flare reactions than controls, possibly due to disturbed skin barrier function. Higher histamine doses, however, produced weaker subjective and vascular reactions in AD patients. In contrast to the controls, AD patients were unable to distinguish between weak and strong histamine stimulation, as shown by their VAS ratings. These results imply that AD patients have an altered histamine response. In particular, their afferent cutaneous nerve fibers show a decreased ability to signal itching to the central nervous system and to release vasoactive neuropeptides upon histamine stimulation.
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PMID:Skin reactions and itch sensation induced by epicutaneous histamine application in atopic dermatitis and controls. 267 98

Atopic dermatitis (AD) is a chronically-relapsing disease of the skin caused by hereditary hypersensitivity to a lot of environmental substances. Disturbances of humoral and cellular immunity, abnormal vascular reactions and abnormal skin functions play a role in pathogenesis. AD shows different forms in different age-groups with pruritus as a commune feature. The treatment of AD is unsatisfactory and effective only by consequent cure. The principles are avoiding of pruritus and scratching, avoiding of chemical and mechanical irritants of the skin and avoiding of bacterial superinfections. Topic steroid-treatment is very effective, dose and application however have to be strongly controlled. The nutrition of children with AD should be as normal as possible, extreme regimes of diet have to be avoided. An effective prophylaxis of atopic disease is not known till now.
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PMID:[Recommendations for the treatment and prevention of atopic dermatitis in children]. 268 83

To record the potentially serious side-effects of melanoma and non-melanoma skin cancers and ocular damage following long-term PUVA chemotherapy, we re-examined 198 of 242 patients. These comprised: 90 with psoriasis, 27 with parapsoriasis, 19 with cutaneous T-cell lymphoma, 23 with vitiligo, eight with cutaneous mastocytosis, 16 with atopic dermatitis, three with prurigo nodularis, two with polymorphous light eruption and 10 with pruritus of chronic renal failure on dialysis, treated between 1977 and 1987 in our department. During the 10-year period, 11 patients died of unrelated disease. None of the patients reviewed had previous skin cancer or had been treated with arsenic, methotrexate or ionizing irradiation before PUVA treatment. None of the patients were children under 16 years of age. The mean age was 54.5 years, the sex ratio 102:96 (M:F). The mean cumulative dose of UVA for the whole group was 169.5 J/cm2. One patient with psoriasis, psoriatic arhropathy, ankylosing spondylitis and Crohn's disease, who was on azathioprine for 6 years, developed squamous-cell carcinoma on the left lower leg. Another patient with pustular psoriasis, who received PUVA treatment to her palms and soles only, developed malignant lentigo of Hutchinson on the right lower leg. PUVA lentigines were found in about 20% of patients. All patients had a yearly ophthalmological examination. None of them developed cataracts, lens opacities or had impairment of their visual acuity.
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PMID:Cutaneous and ocular side-effects of PUVA photochemotherapy--a 10-year follow-up study. 269 Nov 34

The authors assess the clinical efficacy of sibicort, and ointment manufactured by Orion, Finland, used in therapy of patients suffering from neurodermatitis, eczema, and allergic dermatitis. Pathogenetic treatment combined with sibicort has been administered to 64 patients with disseminated true eczema, 115 ones with diffuse neurodermatitis, and 20 ones with allergic dermatitis. The ointment has been applied to and a little bit rubbed in the foci of lesions twice a day. Sibicort has proved to be a highly effective external drug for the treatment of allergic itching dermatoses. Both immediate and late results have been the best in neurodermatitis patients. No side effects or complications associated with this ointment application have been observed; the drug has been well tolerated.
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PMID:[The use of sibicort in the combined therapy of patients with eczema, neurodermatitis and allergic dermatitis]. 272 10

The number of scratching episodes and average frequency with which they started during each sleep stage as well as the effects of nighttime pruritus on objective sleep parameters in nine children with atopic dermatitis were assessed in the sleep laboratory. Scratching episodes occurred during rapid eye movement (REM) sleep and non-REM (NREM) sleep. The largest average frequency corresponded to stage 1, followed by stage 2, REM sleep, stage 4, and stage 3. Sleep maintenance was markedly altered. Total sleep time decrease was related mainly to smaller amounts of stage 4 NREM sleep. REM sleep percentage of total sleep time was increased as compared with normal children of the same age. Furthermore, in six of nine patients REM sleep latency was found to be decreased.
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PMID:Sleep and nighttime pruritus in children with atopic dermatitis. 276 86


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