Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0033774 (pruritus)
 14,546 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sweet itch is an intensely pruritic dermatitis of horses recurring annually in Ireland from April to November. The tissue changes of sweet itch have similarities to immediate-type hypersensitivity reactions which occur in skin sensitised to the saliva of bloodsucking insects. There was subepidermal oedema, and marked eosinophilia; the blood vessels were tortuous and enlarged. Microfilaria were not found in serial sections of lesions of 5 affected horses. The histopathology of the immediate dermal remal reaction to the intradermal injection of Culicoides extract shows dermal vasodilation and eosinophil diapedesis. Seven horses challenged intradermally with whole extract of Culicoides, Stomoxys calcitrans, Tabanidae and saline, gave immediate reactions to Culicoides, 3 gave immediate reactions to Stomoxys calcitrans. Immediate and delayed reactions only occurred at the sites of challenge with Culicoides extract. Three normal ponies when challenged intradermally with extracts of biting flies, showed minimal dermal reactions.
 ...
PMID:A report on clinical aspects and histopathology of sweet itch. 73 65

Common fruits and vegetables were tested as such with the "scratch-chamber" method in 388 patients with various atopic disorders. Of the patients with hypersensitivity to birch pollen, 36% showed immediate positive responses to these natural, fresh materials. Apple, carrot, parsnip and potato elicited reactions more often than, e.g. swede, tomato, onion and parsley. On the basis of clinical data, the relevancy of the results of the skin tests was 80-90%. Both "false positive" and "false negative" responses were seen. Itching and tingling with or without oedema of the lips, mouth and tongue were the most common complaints after eating raw fruits and vegetables. In addition, laryngeal and abdominal disturbances, rhinitis and hand dermatitis were recorded. Among patients without allergy to birch pollen, reactions to fruits and vegetables were rare. The nature of the allergens could not be determined.
 ...
PMID:Immediate reactions to fruits and vegetables. 87 78

Ammonium persulfate is widely used to "boost" peroxide hair bleaches. These persulfates can produce a variety of cutaneous and respiratory responses, including allergic eczematous contact dermatitis, irritant dermatitis, localized edema, generalized urticaria, rhinitis, asthma, and syncope. Some of these reactions appear to be truly allergic while others appear to be due to the release of histamine on a nonallergic basis. Patch tests may be performed with 2% to 5% aqueous solution of ammonium persulfate. Scratch tests may result in asthma and syncope. In some patients, merely rubbing a saturated solution of ammonium persulfate into the skin will evoke a large urticarial wheal. Hairdressers should be made aware that these ammonium persulfate hair bleach preparations may provoke severe reactions and should seek medical attention if the client complains of severe itching, tingling, a burning sensation, hives, dizziness, or weakness.
 ...
PMID:Persulfate hair bleach reactions. Cutaneous and respiratory manifestations. 96 35

Dermatitis in a breeding colony of black (C57BL/6 Nya) mice was characterized by intense pruritus leading to self-mutilation and death. The cause appeared to be infestation with the mite, Myobia musculi. Ulceration of the skin resulted in exudation of serum proteins and exposure of the animals' immune defenses to microorganisms and irritants, with subsequent hyperplasia of regional lymph nodes and spleen. Affected mice had an increase in sessile plasma cells, serum immunoglobulin concentration, and percent of circulating granulocytes. The mites were eliminated by treatment with a dichlorvos-ronnel combination in liquid form, which was dispensed onto the bedding with an automatic syringe. The incidence of dermatitis was reduced to zero. Our experience with M musculi in two other strains of mice, both white, indicates that pathogenicity of this mite for mice varies according to the strain, sex, age, and individual differences in sensitivity of the mice as well as the mating ratios employed.
 ...
PMID:Apparent acaridal dermatitis in a C57BL/6 Nya mouse colony. 97 45

Schistosomiasis mansoni, a potentially severe disease that victimizes an appreciable number of US citizens in this hemisphere, shows cutaneous changes corresponding to various stages in the life cycle of the causative parasite within its definitive host. A transient pruritus or dermatitis, probably irritative, characterizes the stage of cercarial penetration. Urticaria, periorbital edema, and rarely a purpuric eruption may occur four to six weeks later, shortly after oviposition by adult worms, probably as an expression of hypersensitivity to ova and their products. Papulonodular lesions, similar to but not as devasting as those developing internally, may rarely appear months later at the perineum or distant cutaneous sites as a manifestation of granulomatous hypersensitivity to eggs and, very rarely, worms, accidentally carried there through collateral and anastomosing vascular pathways.
 ...
PMID:Dermatologic manifestations of Schistosomiasis mansoni. 98 59

Papular acrodermatitis of childhood is an infectious disease characterized by a non-relapsing, non-itching, monomorphic erythemato-papular dermatitis limited to the face and limbs. It is always associated with anacute hepatitis, with hepatitis B antigen in the serum and with a reactive reticulohistiocytic lymphadenitis. In childhood other types of papular or papulovesicular acro-located eruptions, itching or non-itching, associated with reactive lymphadenitis, are observed, in the course of known diseases and with unknown cause. These acro-located cutaneous eruptions of unknown origin, which show varying features, should be classified as "papulovesicular acrolocated syndrome" until their ethiopathogenesis is known.
 ...
PMID:[Infantile papular acrodermatitis. Acrodermatitis papulosa and the infantile papulovesicular acrolocalized syndrome]. 99 19

Five patients with mycosis fungoides who had developed contact dermatitis to a nitrogen mustard, mechlorethamine hydrochloride, even in low concentrations (1 to 5 mg/100 ml), received daily total-body applications of extremely dilute solutions (0.01 to 0.1 mg/100 ml) of mechlorethamine. The concentrations of the drug were approximately doubled weekly if the patient could tolerate it, or they were raised more slowly if the patient could not. Attempts to desensitize one patient were discontinued since he was unable to tolerate a greater concentration than 1.0 mg/100 ml after trying for one year. Another patient was able to tolerate a concentration of 3 mg/100 ml after three months, at which time his skin had completely cleared and treatment was stopped. Three other patients were desensitized during a period of 8 to 13 months to the point of tolerating the full therapeutic concentration used in our clinic (20 mg/100 ml) without experiencing dermatitis or pruritus.
 ...
PMID:Mechlorethamine desensitization in therapy for mycosis fungoides. Topical desensitization to mechlorethamine (nitrogen mustard) contact hypersensitivity. 112 50

This retrospective study was performed in order to evaluate the frequency and the causes for itching during pregnancy. The series consists of 129 pregnant women with generalized itching, which is 1.2% of all deliveries. The most common cause for itching was hepatosis of pregnancy (83%). The other causes were pruritus of pregnancy without any liver dysfunction (12%), dermatitis (3%) and other (2%). The average time of the onset of itching was the 30th pregnancy week in hepatosis of pregnancy and the 26.5th pregnancy week in pruritus of pregnancy. The frequency of toxaemia of pregnancy varied within 24-33% in the different itching groups and that of urinary tract infection within 21-33%. The proportion of urinary tract infection was also fairly high, 23-24%, among the previous diseases. Perinatal mortality in previous pregnancies was reported by 14 patients (9.0%), 11 of them in hepatosis group (9.6%). The corresponding frequencies of perinatal mortality in the present pregnancy were 1.6% and 1.9%. The drugs most frequently used during the present pregnancy before admission were antibiotics and other chemotherapeutic agents, sulphonamide being the most common.
 ...
PMID:Itching during pregnancy. 113 34

Dermatophilosis was diagnosed in 2 of 13 captive polar bears (Thalarctos maritimus), causing generalized dermatitis of 3 years' and 6 months' duration, respectively. Progressive clinical signs included yellowing and darkening of the hair, pruritus, encrustation of skin, and reluctance to bathe. Dramatic resolution of lesions occurred during 8 weeks of twice-weekly intramuscular treatment with long-acting penicillin.
 ...
PMID:Dermatophilosis in two polar bears. 117 47

6 cases of acrodermatitis papulosa eruptiva infantum (acrodermatitis papulosa infantilis or Gianotti-Crostisyndrome: G.C.S.) were observed and the clinical features of this disease are discussed. 1. An erythemato-papular dermatitis mainly of the face, legs, arms, buttocks, not itching, without re-occurrence lasting on the average 20--25 days. 2. An distinct enlargement of the lymph nodes, especially of the inguinal and axillary areas (reactive reticulo-histocytic lymphadenitis). 3. Acute hepatitis, mostly without icterus. 4. Presence of HB Ag-Australia Antigen in the serum of patients a few days after the onset of the disease. Doubts concerning the entity of G.C.S. are getting irrelevant considering the distinct characteristics. The viral genesis already suggested by Gianotti and Crosti of the picture of the disease seems to be true: in all cases Australian antigens are positive. The infectiousness, but the small danger of infection, even if the disease dates back a few months, should not be underestimated. When diagnosing G.C.S. among others the akrolocalized papular-vesicular syndrome described by Crosti and Gianotti should be considered. In 2 patients we could find by electron microscopic studies microtubular aggregates having a diameter of 200 A. These aggregates were situated in the cytoplasm of endothelial cells of smaller vessels in the upper part of the corium.
 ...
PMID:[Entity of the Gianotti-Crosti's syndrome and its relation to hepatitis B infection]. 118 90


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>