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Query: UMLS:C0033774 (pruritus)
 14,546 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We reported a case of verrucous carcinoma of the vulva, (VCV) presented at an 71 year old caucasian woman, who was admitted to University of Chile Clinical Hospital, December 11, 1987. She had complained of vulvar itching, pain and a tumor at left labium mayor during the last ten years. The tumor was removed, and then a simple vulvectomy with bilateral superficial lymphadenectomy through separate groin incisions was performed. All the 27 inguinal nodes were free of metastasis, and the vulvar skin presented a mixed dystrophy with light atypia (VIN I). She is alive and well one year after surgical treatment.
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PMID:[Verrucous carcinoma of the vulva]. 248 77

Chrysaora hysoscella L. rarely occurs in coastal waters of the Adriatic sea and is usually considered an innocuous jellyfish. In June 1989, P.D.N., a 29 year old healthy female, biologist at the Marine Biology Laboratory of Trieste, treated some samples of Chrysaora hysoscella captured that day. She took the animals from the transport tanks and cut the tentacles and oral arms from their bell. About ten minutes later she felt itching and burning of her hands, especially the right one. Twenty minutes later erythematous and slightly edematous lesions appeared on her fingers. These lesions spontaneously disappeared in about 2 hours. We decided to test Chrysaora hysoscella dermotoxicity on healthy volunteers by cutting a Chrysaora hysoscella tentacle and placing it on a gauze soaked in a solution of 3% NaCl and applying then to the volar side of the right wrist for one minute. Both volunteers presented itching and burning within forty seconds of contact. Three minutes later erythematous and vesicular lesions appeared on the sting site. To the best of our knowledge this is the second reported but first documented report of the dermotoxic effect of Chrysaora hysoscella. We underline that the absence of other previous reports may be due to both the relative rarity of this jellyfish and to the fact that people often confuses Chrysaora hysoscella with other more common jellyfish.
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PMID:[Dermatotoxicity caused by Chrysaora hysoscella. Presentation of a case]. 257 54

A case of hepatitis is reported in a 38-year-old alcoholic woman taking disulfiram to aid in maintaining sobriety. She presented with anorexia, vomiting, fatigue, right upper-quadrant pain, pruritus, darkened urine, and jaundice after about two weeks of disulfiram 500 mg/d. The patient also had been taking enalapril 10 mg/d for one year. Hepatocellular enzymes, total bilirubin, and eosinophils were significantly elevated. Hepatitis B core antibody, hepatitis A antibody, hepatitis B surface antibody, and antinuclear antibody were negative. After discontinuation of disulfiram, the clinical and biochemical manifestations of hepatitis began to resolve and the patient was discharged in a much improved condition. Seventeen previous cases of disulfiram-induced hepatitis are reviewed. It has been suggested that the mechanism of hepatotoxicity is an allergic or hypersensitivity reaction. The findings in this case are consistent with the earlier descriptions of hypersensitivity hepatitis, and lend further support to the possibility that disulfiram may cause hepatitis.
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PMID:Disulfiram-induced hepatitis: case report and review of the literature. 268 28

A female patient aged 39 with urticarial vasculitis is described. She has developed stubborn not itching blisters on the skin, suffered from periodic fevers, arthralgias; laboratory analyses have shown leukopenia, hypocomplementemia, immune complexes circulating in the blood and fixed in the skin vessel walls. Histologic examination has revealed leukocytoclastic vasculitis. The differential diagnosis between this condition, chronic urticaria, and lupus erythematosus is discussed.
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PMID:[Urticarial vasculitis]. 276 11

A case report is presented of a 43-year-old woman with generalized peliosis hepatitis that developed during longterm use of oral contraceptives (OCs). The patient had been in good health until the last 2 years when she began to experience vague epigastric pains and a feeling of abdominal distension. Several months prior to admission, she had started to complain of itching and fatigue. There was no history of dark urine, white stools, or hepatitis. On physical examination, no jaundice or cutaneous stigmata of chronic liver disease were observed. Laboratory studies showed a normal erythrocyte sedimentation rate and hematological blood count. A radionuclide study of the liver showed hepatomegaly; especially the left lobe was enlarged. A computerized tomographic scan of the liver showed multiple areas of decreased density in both of the enlarged lobes. There was no evidence of a tumor. Selective transfemoral angiography of the celiac artery also showed hepatic enlargement but no signs of a space-occupying lesion. At laparoscopy, the liver was grossly enlarged and had a lumpy appearance, but again there were no signs of a tumor. No evidence of veno-occlusive disease or hepatocellular adenoma was found. The diagnosis was peliosis hepatitis. The OCs were withdrawn, and the patient was discharged. Regular follow-up in the outpatient department showed no decrease in the size of the liver. The alkaline phosphatase level rose. The fatigue became worse, and cholestyramine was prescribed for progressive itching. In September 1980, the patient was admitted for reevaluation. A repeated CT scan and angiography of the liver again yielded no evidence of a tumor. Esophagoscopy showed the presence of varices grade 2. The liver at laparoscopy had the same appearance as it had in 1976. Histological examination of a biopsy specimen showed occasional dilated sinusoids and locally marked periportal and intralobular fibrosis. No regeneration nodules were found. The diagnosis was liver fibrosis. The patient's condition deteriorated gradually in the following years. She experienced increasing fatigue. Steatorrhea developed, and the patient lost weight. She needed increasing doses of cholestyramine and oral supplementation of vitamins A, D, and K. She was admitted for a 3rd time in February 1985. Esophagoscopy revealed varices grade 4. A CT scan of the liver showed no change. The patient successfully underwent an orthotopic liver transplantation in January 1987. The diagnosis of peliosis hepatis was well documented in this patient.
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PMID:Generalized peliosis hepatis and cirrhosis after long-term use of oral contraceptives. 312 33

A case of phenytoin-induced hepatitis with mononucleosis is reported, and syndromes associated with phenytoin hypersensitivity reactions are discussed. A 23-year-old black woman with a two-month history of seizure disorder was admitted to a hospital with nausea, vomiting, fever, lymphadenopathy, diffuse maculopapular rash, left-upper-quadrant tenderness, and hepatomegaly. She was receiving phenytoin sodium 300 mg/day; carbamazepine 200 mg four times daily had been discontinued four days before admission because of leukopenia. Phenytoin was discontinued after admission; however, phenytoin 1 g i.v. was given for a tonic-clonic seizure two days after admission, after which swelling of the face and legs and pruritus developed. Over the next few days, signs and symptoms of hepatotoxicity progressed, and she became comatose. Seizures were treated with diazepam. She began to recover after 10 days of supportive therapy and was discharged several weeks later on primidone therapy. Serious phenytoin hypersensitivity reactions may appear as dermatologic, lymphoid, or hepatic syndromes. Fever, rash, and lymphadenopathy often accompany hepatic injury. Encephalopathy and death may occur. Proposed mechanisms for phenytoin hypersensitivity include antigen-antibody reactions, alteration of lymphocyte function, and an enzyme abnormality causing the production of toxic metabolites. Treatment is supportive; phenobarbital and carbamazepine may be used with caution as alternate anticonvulsant therapy. The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.
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PMID:Phenytoin-induced hypersensitivity reactions. 367 71

A woman complained of severe itching and flushing after sexual intercourse or other physical contact with her husband. She developed a weal and flare on intradermal testing with her husband's semen and sweat, pooled donor semen and the sweat from her 2 sons. This is a report of allergy to human semen and the 1st reported case of allergy to human sweat.
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PMID:Woman allergic to husband's sweat and semen. 370 44

With the recent influx of southeast Asians into the United States, an increased incidence of human gnathostomiasis can be expected. A Laotian woman had had two weeks of pruritus associated with fleeting erythematous patches on her abdomen. A peripheral eosinophilia was present. She withdrew a Gnathostoma spinigerum from the skin of her abdomen. Gnathostomiasis is endemic in much of Asia and causes not only migratory cutaneous swellings with erythema but also serious visceral sequelae such as eosinophilic encephalomyelitis. Excision of the parasite is the treatment of choice when possible.
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PMID:Gnathostomiasis. Infestation in an Asian immigrant. 670 56

The article presents the case of a 38 year old patient, on OC (oral contraception) for 10 years. She had had recent administration of triacetyloleandomycin for a sinusitis. Pruritus and jaundice appeared suddenly and hospitalization was advised. Laparoscopy showed a cholestatic liver, and lobectomy diagnosed the presence of an hemangioma. If it is not possible to associate with certainty OC administration with the presence of benign hepatic tumors, it is possible to state that OC increases their volume and favors their rupture.
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PMID:[Jaundice and hepatic hemangioma after ten years of oral contraception and recent administration of triacetyloleandomycin]. 697 2

A 58 year old female patient with diabetes manifested 30 years ago is reported. She had digestive disorders since 20 years ago, and a diagnosis of cholecystopathy had been established. Furtherly, she had jaundice, acholia and pruritus; this picture remitted spontaneously. During the next year she had again jaundice, epigastric pain and vomitings; this picture also remitted with home rest. Fifteen days prior to her admittance she had again jaundice, epigastralgia extending to the back, vomitings and pruritus, as well as a diabetic uncontrol. She was admitted though bile ducts were not roentgenographically explored as a result of iodine allergy. A Fasciola hepatica was intraoperatively found.
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PMID:[Extrahepatic obstructive jaundice caused by Fasciola hepatica]. 699 49


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