Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The renal function of 27 pregnant women with EPH-gestosis were determined by measuring the level of proteinuria, the serum concentration of blood-urea-n (BUN), creatinin, beta 2-microglobulin and the creatinin clearance, in comparison with, 39 healthy pregnant women were examined. For statistics the regressions line with the week of gestation and spearman correlation between our parameters (proteinuria, BUN, creatinin, creatinin clearance and gestosis-index) were determined. The level of the proteinuria as well as the concentration of BUN and serum-creatinin are only limited useful to check the degree of a restriction of the renal function in EPH gestosis. Significant correlations were found between beta 2-microglobulin concentration and the serum creatinin concentration as well as the creatinin clearance, but not between beta 2-microglobulin and the gestosis index. Immunologic reactions in EPH-gestosis seem not to have a significant influence on beta 2-microglobulin concentration, but only the restriction of the degree of the glomerular filtration. Therefore beta 2-microglobulin is a useful parameter for renal function.
 ...
PMID:[Beta 2 microglobulin in the serum as a parameter for the evaluation of kidney function in pregnant patients with EPH gestosis]. 635 86

Immunofluorescent findings are revealing EPH-gestosis as an immunological disease similar to graft rejection. Deposits of immunoglobulins, complement, and fibrinogen/fibrin are localized in the glomerular capillaries, mesangium of the kidney and in the decidual arteries resembling findings in transplanted organs with signs of rejection. Fibrinoid changes of the villous stroma are found in greater amounts in placentae after gestosis revealing a more lively humoral reaction of the immune system. By mixed lymphocyte culture a cellular hyperreactivity of the mother against her fetus can be demonstrated. In conclusion, gestosis is a disease of humoral and cellular hyperreactivity finally resulting in the well-known peripheral symptoms edema, hypertension, and proteinuria. Early diagnosis followed by an effective therapy is desirable in preventing these secondary effects.
 ...
PMID:[Immunological concepts of the etiology of EPH-gestosis]. 644 14

Edema proteinuria hypertension gestosis represents a disease syndrome that is defined by its occurrence in association with pregnancy and by its patient population. Although the difference between true and superimposed EPH-gestosis remains poorly defined clinically, a clearer definition seems feasible if epidemiological data, which have been developed in long-term follow-up studies, are utilized. These circumstances permit the identification of a well-defined, young, primiparous population that is afflicted during pregnancy with a disease syndrome of unknown etiology. Among many suggested theories, the immunologic concept of EPH-gestosis has attracted increasing attention over the recent past. Assuming an immunologic etiology for this disease syndrome, EPH-gestosis is understood to represent a partial or total malfunction or maladaptation of the immune system of the mother and/or the fetus. According to this concept, EPH-gestosis is considered to represent partial rejection of the fetal allograft. In the present review evidence for an immunologic etiology of EPH-gestosis has been summarized. It may be concluded that, in spite of a large body of available information, no definitive proof for an immunologic etiology of EPH-gestosis has yet been presented. Only the further clarification of the immunologic processes involved in the tolerance of normal pregnancy will allow the detection in those mechanisms of abnormalities associated with EPH-gestosis. Until then, EPH-gestosis will remain a condition of unknown etiology. The immunologic concept, similar to other concepts, needs further clarification until the "concept" can become an etiology.
 ...
PMID:The immunologic concept of EPH-gestosis. 703 92

Gestosis index score at delivery was compared with factors reflecting the fetal development in a series of 95 patients with EPH-gestosis collected in Okayama University Medical School in 1975-1979. The prediction of small for date (SFD) was performed by means of multivariate analysis of 10 variables, i.e. gestosis index, maternal body weight, height, uterine fundal length, abdominal circumference, maternal age at delivery and urinary estriol within one week prior to delivery. The result was that gestosis index was as useful as uterine fundal length in predicting SFD. The more gestosis index score increased, the more markedly the fetal development ws disturbed. Especially in the cases with scoring above 4 and in those with hypertension and proteinuria, the incidence of SFD increased obviously. No correlation between gestosis index and neonatal asphyxia was noticed. From the growth pattern of uterine fundal length and BPD, intrauterine growth retardation (IUGR) in pregnancy with EPH-gestosis occurred mainly within the third trimester of pregnancy. The functional development of the fetus with EPH-gestosis was evaluated with the use of urinary estriol level and fetal heart rate (FHR) monitoring. In the cases with EPH-gestosis scoring above 4, extreme disturbance of functional development of the fetus was observed.
 ...
PMID:Estimation of gestosis of pregnancy (EPH-gestosis), relationship between fetal development and gestosis index. 719 59

Five cases of pregnant woman with symptoms of right upper quadrant pain, hemoconcentration, liver dysfunction, and thrombocytopenia are presented as representative of impending gestosis. Plasma volume expansion achieved by either bed rest or intravenous albumin administration appeared to be effective therapy. It is presumed that impending gestosis represents an early form of severe toxemia (edema/proteinuria/hypertension [EPH[ gestosis).
 ...
PMID:Impending gestosis. 731 42

In recent years the syndrome of hemolysis, elevated liver enzymes and low platelets (H-ELLP) has attracted increasing interest in obstetrics as a serious complication of pregnancy, either alone or in combination with the classical symptoms of EPH-gestosis or eclampsia. In 1993, we observed 3 cases of severe HELLP syndrome in a total of 1126 deliveries. We present the clinical characteristics and the laboratory findings in these cases. A common symptom was general malaise and upper abdominal discomfort or pain. All patients were delivered by cesarean section of healthy infants. We conclude that it is no longer sufficient to emphasize edema, proteinuria and hypertension, but that the signs and symptoms of the HELLP syndrome present a new and increasingly important challenge in obstetric practice.
 ...
PMID:[HELLP syndrome in routine obstetrical care. Three case reports]. 794 27

Proteinuria in preeclamptic women was qualitatively differentiated and in cases of pure glomerular proteinuria three groups according to the low-, medium- or high selectivity of glomerular proteinuria were formed. In these patients the incidence of liver dysfunction and severe proteinuria together with an increase in mean arterial blood pressure was investigated. The aim of this study was to find out if there is any connection between glomerular proteinuria of different selectivity and disturbed liver function. In patients with EPH-gestosis a pure glomerular proteinuria in SDS-PAA-disc electrophoresis of the urine was found. Together with the increase in glomerular selectivity an increase in quantitative urinary protein loss was found. In patients with high selective glomerular proteinuria the extent of proteinuria was about three times higher than in patients with low selectivity. In all patients a moderate elevation of the liver enzymes was found. In all patients disturbed liver function returned to normal within a few days after delivery. We conclude from these data that glomerular functional lesions pregnancy in patients with preexisting glomerulopathies or pregnancy induced renal dysfunction are accompanied in a high rate by moderate disorders of liver function.
 ...
PMID:[Selectivity of glomerular proteinuria and liver function in gestosis]. 804 89

A dynamic dopplerometry of the blood flow in the mother-placenta-fetus system, carried out in 79 women with EPH gestosis, revealed a direct correlation between uteroplacental and fetoplacental blood flow disturbances and gestosis, hypertension, edematous syndrome, and proteinuria severity. Comprehensive assessment of the blood flow in both uterine arteries and umbilical artery are preferable. When third-degree circulatory disturbances are revealed in the mother-placenta-fetus system, cesarean section is recommended. Comprehensive dopplerometric assessment of uterine and umbilical arteries blood flow may be regarded as an objective indicator of gestosis severity, whatever its clinical manifestations.
 ...
PMID:[The clinico-diagnostic importance of evaluating the blood flow in the mother-placenta-fetus system in EPH gestosis]. 804 77

This study represents a retrospective analysis of pregnancies with chronic arterial hypertension and their outcomes. The aim was to evaluate the influence of arterial hypertension on 101 essential and 109 cases of secondary hypertension in comparison to the control group consisting of 499 normotensive pregnancies. According to the obtained data, 27.7% of the women with chronic hypertension had proteinuria, 61% had bacteriuria and 58.6% had superimposed EPH gestosis. The occurrence of EPH gestosis among the controls was 5.6%, that is significantly less than in the experimental group (X2 = 282.8%; p < 0.001). The outcomes of pregnancies associated with chronic hypertension were: 19% preterm deliveries compared to the controls in which only 9.2% preterm deliveries occurred (X2 = 14.4; p < 0.001). Newborns from pregnancies with essential hypertension were significantly heavier, weighing 3177 +/- 734 g, than those from pregnancies with secondary hypertension, which weighted 2578 +/- 932 g. Perinatal mortality was higher in the study group and significantly higher in the pregnancies with associated secondary hypertension (30.3%) than in pregnancies associated with essential hypertension (15.8%).
 ...
PMID:[Fetal growth in pregnant women with chronic hypertension]. 817 92

The change in plasma concentration of human hepatocyte growth factor (hHGF) in pregnant women with HELLP (hemolysis, elevated liver enzyme and low platelets) syndrome was investigated, and the following results were obtained. (1) The plasma concentration of hHGF in pregnant women did not change with the gestational stage. (2) The plasma concentration of hHGF in pregnant women with EPH (edema, proteinuria and hypertension) gestosis was 0.19 +/- 0.07 ng/ml and did not differ greatly from that in control pregnant women. (3) The plasma concentration of hHGF in pregnant women with HELLP syndrome was 1.79 +/- 0.35 ng/ml; it was increased prominently compared to control pregnant women. (4) The plasma concentration of hHGF in pregnant women with HELLP syndrome changed parallel to the clinical symptoms of the syndrome.
 ...
PMID:Clinical use of human hepatocyte growth factor in the early detection of HELLP syndrome. 883 69


<< Previous 1 2 3 Next >>