Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Urinary dopamine (DA) and sodium excretion in patients with nephrotic syndrome (NS) were studied under various sodium loading in metabolic ward. Twenty patients and 10 age-matched normal volunteers were enrolled in this study. When they were on a low-salt diet (34 mmol/d), urinary excretion of DA and sodium in patients with heavy edema were much lower than that in normal controls, while in patients with mild or without edema, urine DA and sodium excretion did not decrease significantly, but were not mobilized on sodium loading (170 mmol/d), and the plasma renin activity and aldosterone were not completely suppressed as well. The decrement of urine DA excretion was independent of Ccr or the severity of renal tubule lesions, but was associated with the severity of proteinuria. When the proteinuria reduced, urine DA and sodium excretion increased. From the above observations, we might assume that the abnormal retention of sodium and water in NS was due partly to a failure to mobilize DA in the kidney and the change of the physical environment in renal tubule caused by heavy proteinuria was responsible for it.
Zhonghua Nei Ke Za Zhi 1992 Sep
PMID:[Is the renal dopamine involved in the sodium retention in the nephrotic syndrome?]. 130 50

581 early cases of typical hemorrhagic fever with renal syndrome (HFRS) were dynamically studied on the clinical manifestations and laboratory findings from 1986 to 1989. All the patients were treated with various methods. The results showed: (1) The manifestations of microvascular damage, proteinuria and thrombocytopenia can be found at the first day of the onset in 80.0%, 72.2% and 33.3% respectively. In a word, the characteristic features of HFRS appear at the onset of the disease. (2) In 446 early cases the initial severity of the disease corresponded with the final severity at a rate of 89.2%; it indicated that the damage of HFRS may result from the first attack. (3) The time of the onset, peak and persistence of all the characteristic features were similar; it is suggested that the course of HFRS may be self-limited. (4) Based on the clinical understanding and the effective results in the 446 early cases treated with fluid therapy alone, we consider that the effective treatment of HFRS is early and reasonable fluid therapy.
Zhonghua Nei Ke Za Zhi 1992 Mar
PMID:[A study on pathogenesis and therapy of hemorrhagic fever with renal syndrome]. 135 14

This present study first reported 8 cases of Thin membrane nephropathy (TMN) in China. Most patients had persistent microscopic hematuria, who could be accompanied with mild proteinuria or macroscopic hematuria. The contrast microscopy showed glomerular hematuria in the majority of the cases. Some patients (25%, 2 cases) had familial hematuric histories, suggesting this disease may be associated with heredity. All the patients had normal renal function at following-up period (average 2.9 years), this result showed this disease was benign glomerular disease. LM showed pathological change is mild, IF was negative, diffuse thin GBM was outstanding change by EM. The thickness of TMN was 265 +/- 39 nm, the thickness of IgA GN and normal control were separately 383 +/- 32 nm and 398 +/- 34 nm, the thickness of TMN was significantly thinner than IgA GN and normal control (P less than 0.01). This study showed ultrastructural observation of glomeruli by EM was necessary to diagnose this disease.
Zhonghua Nei Ke Za Zhi 1992 Mar
PMID:[Thin membrane nephropathy (TMN). Analysis of 8 cases]. 139 29

In an attempt to evaluate the influence of hypertension and antihypertensive agents on IgAN, IgAN and hypertension experimental models were induced in SD rats and divided into 4 groups: (1) IgAN(n = 8); (2) IgAN+by hypertension(n = 8); (3) captopril 4mg/100gBW/d, for 42 days administered to rats as group (2) (n = 8); (4) nifedipine 300ug/100gBW/d, for 42 days administered to rats as group (2) (n = 8). Blood pressure was measured at the 12th, 14th, 16th, 18th and 20th week. Urinary protein, serum angiotensin II (AT II) and renal pathologic changes were examined at the 20th week. Our results suggest that hypertension worsens IgAN by glomerular mesangial proliferation in early stages. Though Captopril has the same therapeutic effect on hypertension as Nifedipine does, the former has been proven to have potentially beneficial effects on diminishing proteinuria as well as mesangial lesions. This is consistent with the suppression of serum ATII which favours glomerular microcirculation.
Zhonghua Nei Ke Za Zhi 1991 Sep
PMID:[The influence of hypertension and antihypertensive agents on experimental IgA nephropathy (IgAN)]. 180 38

It has been suggested that tubular-interstitial damage may be the main cause of Legionnaires disease (LD) associated acute renal failure (ARF). However, this hypothesis has rarely been examined. In China we firstly describe four patients with LD-ARF, who had proteinuria, hematuria, Leukocyturia and cylindruria. Two patients had nephrotic syndrome indicating acute glomerular injure, one of them was histopathologically proven to be rapidly progressive glomerulonephritis. Scr, UNa, RFI and FENa are markedly increased. Our results suggest that both tubular-interstitial and glomerular damage may be the important causes of LD-ARF in Chinese LD patients. To confirm this hypothesis further investigation are needed.
Zhonghua Nei Ke Za Zhi 1990 Oct
PMID:[Legionnaires disease associated with acute renal failure]. 208 96

Twenty cases of primary nephrotic syndrome were treated with urokinase at a dosage of 60,000 units per day for two successive weeks. The results showed that after treatment the concentrations of fibrinogen, urine FDP, alpha 2-plasma inhibitor and plasminogen were significantly decreased (P value less than 0.01, less than 0.01, less than 0.001, less than 0.005 respectively). The concentration of antithrombin III was significantly increased (P less than 0.05). It is suggested that the treatment obviously increased the fibrinolytic activity and improved the hypercoagulated state. The clinical data showed that in addition to decrease of proteinuria and obvious increase of urine volume, the clinical manifestations and laboratory parameters showed no significant difference. Further study on the dosage and indications of urokinase is needed and the activity of coagulation and fibrinolysis in patients with deep vein thrombosis of lower extremities was also discussed.
Zhonghua Nei Ke Za Zhi 1989 Jun
PMID:[Primary nephrotic syndrome treated with urokinase--a report of 20 cases]. 258 15

The clinical features and long-term outcome of 91 cases of adult-onset PSGN in Hong Kong were reported. There were 46 male and 45 female with age ranging from 13 to 56 yrs (mean 18.6). The diagnosis was based on clinical manifestations and renal biopsy was performed in 29 cases. The main manifestations were acute nephritic syndrome (72.5%) and acute nephritic-nephrotic syndrome (27.5%). Serum creatinine was increased in 48.4% of the patients at presentation. Four cases presented with acute renal failure. Serial serum C3 levels were determined in 48 patients. It was decreased in all patients at presentation but returned to normal within 15 weeks. The follow-up duration of this series ranged from I to 19 yrs (mean 4.73 yr) 67.03% recovered early (within 3 mts); 14.29% recovered later (from 6 mts to 7 yrs): 16.48% had persistent or intermittent proteinuria and or haematuria. Two cases developed chronic renal insufficiency. Our results suggested that the prognosis of PSGN in adults is relatively good and the indications for renal biopsy in adult-onset PSGN were discussed.
Zhonghua Nei Ke Za Zhi 1989 Aug
PMID:[Clinical features and long-term outcome of 91 cases of adult onset post-streptococcal glomerulonephritis in Hong Kong]. 259 33

Hepatitis C virus (HCV) infection is one of the important causes of chronic and severe hepatitis in China. In an attempt to understand if there is any relationship between HCV infection and glomerulonephritis (GN), serum samples from 570 GN patients and 100 normal volunteers were screened for anti-HCV antibody (HCV-Ab) with ELISA method. Among the cases with positive HCV-Ab, serum HCV-RNA was tested with nested RT-PCR method. The incidence of serum HCV-Ab was 2 in 100 normal volunteers (2%) and 34 in 570 GN patients (6%). The incidence of positive serum HCV-RNA was 0 in normal volunteers whereas 21 in GN patients. The main clinical manifestation of GN patients with serum positive HCV-Ab was an unique proteinuria with/without nephrotic syndrome or renal failure, whereas the pathologic lesions in GN patients with serum positive HCV-Ab or HCV-RNA consisted of different disease entities. There was no close link between MPGN and active HCV infection. From the data observed, it seems that there is a coincidence between glomerular diseases and HCV infection rather than a matter of cause and consequence.
Zhonghua Nei Ke Za Zhi 1994 Jun
PMID:[Is there hepatitis C virus associated glomerulonephritis?]. 753 65

Renal biopsy was performed in 31 cases of primary glomerulonephritis and the effect of Hirudo in these patients observed. The results revealed that proteinuria decreased significantly, serum albumin increased significantly and cholesterol, triglyceride reduced significantly 4 weeks after treatment with Hirudo (P < 0.01 or P < 0.05); Fibrinogen and platelet aggregation reduced significantly (P < 0.01). However, platelet count, partial thromboplastin time, bleeding and clotting time did not change (P > 0.05); urine NAGase decreased significantly (P < 0.01). It is concluded that Hirudo may decrease proteinuria and alleviate renal parenchymal damage.
Zhonghua Nei Ke Za Zhi 1995 Apr
PMID:[The effect of hirudo on proteinuria, lipid metabolism and coagulation system in the patients with chronic glomerulonephritis]. 758 5

Ten cases of idiopathic acute renal failure (IARF) in idiopathic nephrotic syndrome (NS) were reported. Heavy proteinuria and severe edema were the main clinical manifestations in these cases. Sudden oliguria, decrease of urinary osmolarity and increase of blood urea nitrogen and creatinine occurred without any difinite cause. Pathological examination showed normal or near normal glomeruli, diffuse interstitial edema and patchy necrosis of the tubular cells. The renal function in all the patients recovered after therapy with diuretics, prednisone, etc. It is shown that IARF in idiopathic NS commonly occurred in patients with normal or near normal glomeruli, for example, minimal change disease (6/10 cases), mild mesangial proliferative glomerulonephritis (4/10 cass). The incidence of IARF in idiopathic NS was 4.1% (10/245 cases), the IARF was mostly reversible.
Zhonghua Nei Ke Za Zhi 1995 Mar
PMID:[Idiopathic acute renal failure in nephrotic syndrome--a report of 10 cases]. 764 34


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