Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

8 cases of membranous glomerulonephritis (MG) after renal transplants (RT) are presented; one being a recurrence of the original disease and the other 7 due to a different cause of renal insufficiency. The total incidence of MG after transplantation was 1.63%; 1.39% being the incidence of MG of new cases. Only 1 patient showed decrease of renal function and in this case the MG was accompanied by chronic rejection lesions. There was no sign of neoplasias nor drugs producing MG. As far as chronic infections are concerned, only one patient showed B antigen and it was not observed during the immunofluorescent test in the biopsy. 6 patients had urological complications after the renal transplant (3 cases of urinary fistula; 2 cases of obstructive uropathy; 1 case of short ureter). 2 patients experienced the start of hemodialysis due to focal and segmentary glomerulosclerosis. The beginning of proteinuria commences between 2 and 23 months after the RT (median 13,0 +/- 7,5 moths); with a range of between 2.0 and 12.0 gr/day (median: 6.8 +/- 3,2 Z gr/day), this being nephrotic in 4 cases. Proteinuria improved 1 case, and persisted in the other patients at the same level registered previous to the diagnosis. MG is a non-frequent complication or RT and is usually benign. Patients with post-transplant urologic complications could be considered to have a higher risk of developing a MG "de novo".
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PMID:[Membranous nephritis after renal transplantation]. 189 4

The clinical and histologic features of 81 patients with IgA nephropathy were analyzed. Azotemia was present in 32 per cent of the patients, proteinuria was present in 88 per cent, and gross or microscopic hematuria was present in all of the patients tested. The median age of histologic diagnosis was 27 years. The median age at onset of clinical signs was 20 years. There was no increased incidence in any HLA-A or -B antigen within the patient population over our control population. All patients had glomerular mesangial IgA deposition (by definition) greater than or equal to IgG or IgM. Histologic changes were quantitated and ranged from normal to necrotizing and/or crescentic glomerulonephritis. Many patients (48 per cent) had mild or moderate generalized glomerlular hypercellularity. Nonparametric statistical analysis showed strong correlations among patient age at histologic diagnosis, creatinine, proteinuria, global glomerular sclerosis, and interstital fibrosis. Our analysis suggests that IgA nephropathy is an indolent disease generally beginning in childhood. It is a cause of renal insufficiency in a significant number of patients. Interpretation of this series and other reported studies suggests that most cases of IgA nephropathy in the United States are best considered idiopathic but that hereditary and secondary forms may exist.
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PMID:IgA nephropathy. Correlation of clinical and histologic features. 621 35

Forty five Cameroonian patients in West Africa who were diagnosed as having membranous glomerulonephritis (MGN) were studied and followed up over a five year period. The mean age of these patients was 32.3 years with a female to male ratio of 5/4. Proteinuria (93.3%) and nephrotic syndrome (89%) were the two most important clinical manifestations at the time of diagnosis. Seventeen cases (37.8%) of the MGN were considered idiopathic while 62.2% were associated with known aetiological factors. Histologically, the majority of patients were at stage I (35.55%) or stage II (37.8%) of the World Health Organisation (WHO) classification. Except of the patients in stage I, most patients in stage II and all those in stages III and IV, showed associated important, tubular interstitial and vascular lesions. Immunofluorescence studies showed deposits to be mainly IgG (80%) and C3 (71.1%) while electron microscopy showed varied dense deposits in all cases. Seventeen patients with idiopathic MGN and 10 MGN patients whose only associates aetiological factor was a positive hepatis B antigen were followed up over 5 years. During this period, eight patients (29.6%) had a complete clinical remission, eleven patients (40.7%) improved their renal function and decreased their 24 hour proteinuria, while eight (29.6%) patients deteriorated into end stage renal failure and had to be commenced on dialysis; three of them died during this procedure.
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PMID:[Extramembranous glomerulonephritis: clinicopathologic finding in a group of 45 Cameroonians]. 1008 84