Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A single intravenous injection of adriamycin (5 mg/kg) into rats caused the full expression of nephrotic syndrome characterized by heavy proteinuria, hypoalbuminemia, hypercholesterolemia, thoracic and ascitic fluid; swelling and fusion of foot processes of epithelial cells could be observed under electron microscope; histologic examination by light microscopy did not reveal any significant changes. The features of the model in clinic and pathology were very similar to those described humans with minimal change nephrotic syndrome. The observation in the various periods of the model indicated that the ultrastructure changes in epithelial cells occurred prior to the onset of proteinuria. The present study, combined with the results of quantitative analysis with image analyzer for alteration of glomerular polyanions, suggests that both morphologic changes and proteinuria may be the consequence of a common primary event that is the loss of glomerular polyanions. The model has the advantages of being rather simple and convenient; providing lasting proteinuria and pathological changes in stable condition; and having high reproducibility and a sufficient supply of the drug used.
Hua Xi Yi Ke Da Xue Xue Bao 1990 Sep
PMID:[Experiment study of adriamycin-induced nephrotic syndrome in rats]. 209 45

A single intravenous injection of adriamycin (5mg per kg.) into rats induced nephrosis. In the various periods of the model, alterations of glomerular anionic sites stained with colloidal iron were analyzed quantitatively by image analyzer for the first time at home and abroad. The results showed that there was a significant decrease in glomerular anionic charge sites at 3 hours after administration of adriamycin as compared with that of the control animals (P less than 0.01). Marked loss of the anionic charge sites preceded the onset of proteinuria and was steadily increasing along with progress of the disease. The results suggest that loss of glomerular anionic charge sites may play an important role in the development of proteinuria in nephrotic syndrome.
Hua Xi Yi Ke Da Xue Xue Bao 1989 Dec
PMID:[Changes of glomerular fixed anionic charge sites in adriamycin nephrosis in rats]. 248 54

Twenty-one patients with Lupus Nephritis (LN) were treated with cyclosporine-A (CsA) for three months. Serum soluble interleukin-2 receptors (SIL-2R) were measured before and after treatment and correlated prospectively with serologic findings of LN activity. The patients had significantly higher IL-2R level before treatment (during LN flare) than after treatment (disease remission). A significant positive correlation was present between serum SIL-2R and proteinuria, and ANA as well, whereas the SIL-2R levels in LN patients were inversely correlated with serum levels of C3 and CH50. These observations suggest that serum SIL-2R level is an useful marker of disease activity in LN and may serve as a helpful adjunct in the management of this disorder.
Hua Xi Yi Ke Da Xue Xue Bao 1995 Sep
PMID:[The use of measuring serum soluble IL-2 receptor levels in cyclosporine-A treated lupus nephritis]. 858 6

We used streptozotocin (STZ) to induce the animal model of diabetes mellitus in rats. On the 7th and 14th days of induction, kidney disorder, the levels of NO3- in plasma and tissue homogenate in different periods were observed. The NO3- levels in relation to the application of L-arginine (L-Arg) were also noted. The results showed that the kidney weight/body weight ratio significantly increased in different periods (P < 0.05). On the 7th day profuse proteinuria appeared and it markedly increased on the 14th day: creatinine clearance rate (Ccr) significantly raised, too (P < 0.005). The NO3- levels in plasma and tissue homogenate were getting higher with time. The level of NO3- significantly increased after L-Arg was perfused. It indicated that kidney disorder was present at the early stage of diabetes, and the raised Ccr indirectly indicated the increase of glomerular filtration rate. These suggest that NO3- and L-Arg may be important mediums which have effects of hyperfiltration and hyperperfusion of glomerulus.
Hua Xi Yi Ke Da Xue Xue Bao 1997 Sep
PMID:[L-arginine and nitric oxide have effects on glomerulus hyperperfusion of early diabetic rats]. 1068 27

This study was aimed to re-evaluate the proteinuria quantitative and qualitative methods for diagnosis of diabetic nephropathy (DN). 136 cases were divided into two groups of proteinuria negativeness and postiveness by the results of urine routine examination. The clinical and biochemical indices and the frequencies of other diabetic complications of the two groups were compared. The results showed that the blood glucose and glycated Hb in the two groups were increased, especially in the proteinuria negative group (P < 0.01 and 0.05, respectively). There was a high prevalence of hypertension and other diabetic complications in the two groups, and it was higher in the positive group than in the negative group (P < 0.05 and 0.01, respectively). The frequencies of hyperlipoproteinemia in the two groups were over 40%, but no significant defference was observed between them (P > 0.05). There was correlation between hypertension and proteinuria (P < 0.01) but no correlation between diabetic retinopathy and proteinuria. The prevalence of azotemia in the proteinuria negative group was 17.07%. These suggest that the amount of proteinuria can not completely reflect the duration and severity of DN. Negative proteinuria in routine examination cannot rule out DN. For diagnosis of DN, it is necessary to think about all data on blood glucose, blood lipid, blood pressure and the change in fundus oculi.
Hua Xi Yi Ke Da Xue Xue Bao 2000 Mar
PMID:[Re-evaluation of proteinuria and qualitive methods for diagnosis of diabetic nephropathy]. 1250 24