Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Radiological findings of segmental renal hypoplasia are reported, based on the observation of 6 children aged between 8 and 14. The leading clinical symptom is arterial hypertension. Urinary tract infection and proteinuria are additional common findings. Cases with bilateral disease often have renal failure. The intravenous urogram shows unilateral or bilateral small kidneys with segmental renal scarring and transverse lobulation. In the pathological areas the calyces are ectatic or clubbed and their infundibulum is elongated. Vesico-ureteral reflux is frequent. In angiography the lobulated segments appear hypovascular. Diagnosis was verified by histological examination.
Pediatr Radiol 1976 Dec 15
PMID:Segmental renal hypoplasia in childhood. 101 4

Urinary excretion of lysozyme was investigated in a group of 66 patients with various renal diseases, nephrolitiasis and urinary tract infections. The results obtained demonstrate that the amount of the enzyme excreted is related to the entity of tubular damage whereas is not with glomerular damage. No correlation was found between lysozyme excretion neither to the degree of proteinuria neither to the amount of leukocytes and bacteria in the urine. In patients with urinary infections urinary lysozyme increases only when there is a tubular injury of some entity. In 90 pediatric patients with urinary infection and pyelonephritis lysozyme in the urine was found only in two cases. Therefore urinary lysozyme determination cannot be considered for the detection of early tubular injury and is not a helpful diagnostic tool in urinary tract infections.
Quad Sclavo Diagn 1976 Dec
PMID:[Behaviour of urinary excretion of lysozyme in renal diseases and in urinary tract infections (author's transl)]. 102 90

The effects of levamisole, ribovirin, and cyclophosphamide in preventing the spontaneous autoimmune disease of NZB/W mice have been evaluated. These drugs all had a significant effect, both in delaying mortality, and in postponing the development of antinuclear antibodies and proteinuria. Single-stranded DNA linked to IgG was also used but had no demonstrable effect. The results of therapeutic studies in murine lupus must be interpreted with caution in relation to the human disease, but as both levamisole and ribovirin are now being used in man, our results suggest that further studies with these drugs are warranted.
J Rheumatol 1976 Dec
PMID:Therapeutic trials with levamisole and other agents in NZB/W mice. 108 66

Administration of D-serine to rats induced acute necrosis of the proximal straight tubules, proteinuria, glucosuria, and aminoaciduria. Proteinuria and glucosuria developed at the onset of tubular necrosis and disappeared when the tubules were completely relined by new epithelium. Our findings suggest (1) that abnormal loss of protein and glucose in urine is due to diffusion of these substances from interstitium to tubular fluid across the denuded permeable basement membranes of the necrotic tubules, and (2) that tubular cells normally are a barrier to diffusion of certain solutes betweeen interstitial and tubular fluids. Amino-aciduria preceded the onset of tubular necrosis and increased excretion of some amino acids persisted after tubular repair. Thus, D-serine-induced aminoaciduria may be due to impaired reabsorption of amino acids by the injured proximal straight tubules, as well as by backward diffusion of amino acids from the interstitium.
Arch Pathol 1975 Dec
PMID:D-serine nephrotoxicity. The nature of proteinuria, glucosuria, and aminoaciduria in acute tubular necrosis. 120 37

33 cases of chronic glomerulonephritis who responded unsatisfactorily to treatment with indomethacin alone were treated in addition with a low dose of cyclophosphamide. The five patients with focal glomerulosclerosis responded poorly. The remaining 28 patients showed a statistically significant improvement in renal function and proteinuria.
Clin Nephrol 1975 Dec
PMID:Treatment of chronic glomerulonephritis with a combination of indomethacin and cyclophosphamide. 120 60

Membranous nephropathy (MN) accounts for about 20 percent of cases of the nephrotic syndrome. The importance of renal biopsy in establishing the diagnosis is emphasized. In the great majority of MN patients, no etiologic factor can be discerned. In a significant minority, MN appears to be a manifestation of sarcoidosis, diabetes, lupus, syphilis, malaria, or toxicity from heavy metals or drugs. In some cases the "cause" is neoplasia (including lymphoma) or a viral infection. Massive proteinuria, hypoproteinemia and edema are the principal manifestations of MN, finally resulting in renal failure. Treatment consists chiefly of diet and diuretic drugs. In the more pronounced cases, corticosteroids may have a favorable effect and in very resistant cases, cyclophosphamide is indicated. Judicious use of these modalities if often associated with the diminution or disappearance of the clinical signs of MN.
J Am Geriatr Soc 1975 Dec
PMID:Membranous nephropathy: an overview. 120 87

The prognosis in patients with glomerulonephritis can now be established with some confidence. The major advance has been the use and interpretation of renal biopsies. The different histological varieties have their own evolution and prognosis. The clinical/pathological correlations assist the physician in determining the prognosis in patients with glomerulonephritis. On the clinical side, the most important observation is the simplest: proteinuria or hematuria may persist separately for many years without alteration of renal function. However, in patients with persistent proteinuria associated with hematuria the prognosis is poor, as the evolution is towards renal failure.
Schweiz Med Wochenschr 1975 Dec 20
PMID:[Proceedings: Evolutive forms of glomerulonephritis and their prognosis]. 121 70

Rats with a nephrotoxic serum nephritis reveal changes of proteinuria and content of serum proteins as well as serum cholesterol in the direction of a nephrotic syndrome as is seen after Daunomycin. Nevertheless, the morphological findings with TEM and especially with SEM are quite different. A striking feature of the nephritis is the rather good preservation of cell processes through all the time of experiment in spite of the elevated proteinuria. Moreover, podocytes with furrowed or ribbed surfaces originate and are most numerous when the signs of inflammation are most pronounced. These furrowed podocytes are interpreted as representing a special reactive, perhaps mobilized form. With SEM it is evident that the glomeruli are altered focally and segmentally in the nephrotoxic serum nephritis.
Beitr Pathol 1975 Dec
PMID:Podocytes of rat kidneys with nephrotoxic serum nephritis. A combined transmission and scanning electron microscopic study. 121 24

1. The detailed anatomy of the structures forming the glomerular filtration barrier and the proximal tubules was studied during development of foetal and neonatal pigs. 2. In the glomerular filtration barrier during ontogenetic development an increased number of fenestrae was noted in the endothelium. The condensation decreased in the glomerular basement membrane and an increase in the widths of the pedicles was observed. 3. The proximal tubular cells revealed a highly specialised organisation with an enlarged cell surface (microvilli) towards the lumen. In the apical part of the cell a zone containing vesicles probably pinched off from the base of the microvilli was observed. At the base of the cell elongated mitochondria and electron dense bodies were found. 4. An increase in the number of vesicles was observed in the proximal tubular cells from piglets receiving colostrum and exhibiting proteinuria. Judging from these results it seems probable that the nephrons are able to function already in the metanephros of the pig foetuses of 4 cm CR-length. 5. The results imply that there was no structural evidence of an immature glomerular filtration barrier being the cause of neonatal proteinuria. On the other hand an enhanced involvement of the cells of the proximal tubules was noted and this is interpreted to be due to the absorption of proteins from the primary urine after onset of colostrum ingestion by the newborn piglet.
Anat Embryol (Berl) 1975 Dec 31
PMID:Functional structure of the glomerular filtration barrier and the proximal tubuli in the developing foetal and neonatal pig kidney. 122 84

A 14-month feeding experiment was conducted with 16 high-yielding cows, each given a daily supplement of 2 kg soya meal regardless of milk yield or the stage of lactation, in comparison with 8 normally-fed cows. At monthly intervals various parameters of carbohydrate, fat and protein metabolism and of liver function were determined. At the end of the trial, samples of liver were obtained by biopsy for morphological and histochemical examination. Supplementation had a pronounced effect on milk yield and fat content, averaging over 900 kg of milk and 0.2% fat content more than during the preceding year. The parameters of metabolism revealed clear signs of subclinical ketosis, particularly during the first third of the trial period. Changes were greatest during the 3rd and 4th months of the trial, when the protein content of the ration was particularly high (over 3 kg) and when the energy supply ratio was particularly unfavourable (PEQ 300). At the end of the trial some abnormalities were detected in individual animals in the biochemical properties of blood and urine, and the morphological, histochemical and ultrastructural appearance of the liver. These changes included increases in KK, BTS and bilirubin concentrations in the blood; ketonuria, proteinuria; perilobular fat infiltration with glycogen depletion; changes in succinate dehydrogenase and acid phosphatase activities. In most animals the liver seemed to have become adapted to a high protein intake.
Arch Exp Veterinarmed 1975 Dec
PMID:[Experimental studies on the ketogenic effect of high doses of proteins in dairy cows]. 124 54


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