Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mice were infected with 1X 107 Plasmodium berghei Yoelii parasites intraperitoneally. Circulating parasite, malaria antibody and C3 concentrations were measures: parasitaemia and hypocomplementaemia were transient, but the antibody response was persistent. Animals were sacrificed at intervals and their kidneys examined: a glomerulonephritis associates with predominantly mesangial deposits of C3, IgG1, IgM and some IgA always developed after 7 days and persisted for up to 6 mth. Malaria antigen and antibody were demonstrated within the glomeruli. Microscopic haematuria occurred with proteinuria but without marked deterioration in renal function. Strains producing high and low affinity antibody were equally susceptible to the disease. Treatment with glucocorticoid, immunosuppressive, platelet function inhibiting and/or anticoagulant drugs, or indomethacin from the 1st day of infection failed to prevent development of the disease or to lead to its early cure. Eradication of the infection within its first 3 days prevented glomerular deposition of antibody and complement, and infection with a smaller antigen load followed by later treatment also produced subsequent cure.
J Pathol 1976 Dec
PMID:Mouse malaria nephropathy. 79 19

Proteinuria is supposedly a frequent and early manifestation of glomerulonephritis. Since albuminuria rather than proteinuria is the hallmark of glomerular disease, the present studies were designed to study the occurrence of albuminuria in normal mice (SWR/J strain) and in mice with a reproducible and predictable immune complex glomerulonephritis induced by chronic infection with lymphocytic choriomeningitis (LCM) virus. A radial immunodiffusion technique, specific for mouse albumin, was employed to quantify the albuminuria. Column chromatography of concentrated urine obtained from normal and nephritic mice demonstrated that albumin excreted in the urine had the same molecular weight as serum albumin and that identifiable fragments of albumin did not appear in the urine. Some albuminuria did occur in normal mice, 0.12 +/- SD. 0.13 mg. per 18 hours for 80 males and 0.13 +/- 0.09 mg. per 18 hours for 55 females. Increased albuminuria, defined as values greater than a normal mean + 2 S.D. (0.40 mg. per 18 hours) occurred in only 25 per cent of nephritic mice, although in more than 600 animals studied, immunofluorescent microscopy invariably demonstrated abnormal accumulation of immune complexes in the glomeruli of SWR/J mice chronically infected with LCM virus. Values of total proteinuria measured by the sulfosalicylic acid method did not correlate with radial immunodiffusion measured albuminuria. The results indicate that measurement of total proteinuria in mice is not a useful parameter of glomerular disease. Albuminuria, while increased in 25 per cent of nephritic animals, was not abnormal even in the presence of marked histologic alterations in 75 per cent of mice, suggesting that abnormal immunopathology may very commonly not be reflected in increased or pathologic albuminuria. Recent observations also suggest that this is the case in humans.
J Lab Clin Med 1975 Dec
PMID:Studies of abluminuria and proteinuria in normal mice and mice with immune complex glomerulonephritis. 81 41

In 37 patients of nephrotic syndrome, serum protein levels, protein fractions and urinary levels of proteins and their fractions were determined. The findings of serum levels of proteins and their fractions were compared with an equal number of age and sex matched controls. Twenty three patients showed selective and 14 non-selective proteinuria. Most of the patients with selective proteinuria showed good response to steroids therapy while those with non-selective proteinuria did not respond.
J Pak Med Assoc 1976 Dec
PMID:A study of protein clearances in patients with nephrotic syndrome. 82 57

Reproducibility of reading "N-Multistix" dipsticks by a semi-automated urinalysis instrument (Ames' "Clini-Tek") has been described for artifically prepared samples. Glucose, ketone, urobilinogen, and nitrite showed high reproducibility (greater than 90%) for reading multiple samples at predetermined analyte concentrations. Determination of proteinuria showed the lowest proportion of false positives (2-3%) and false negatives (0%). Determination of hemoglobinuria and bilirubinuria by dipsticks were the least reproducible. Urobilinogen showed no interference from bilirubin in concentrations up to 32 mg/liter. Precision was high for results for quality-control capsules provided by the manufacturer.
Clin Chem 1977 Dec
PMID:Evaluation of Ames' "Clini-Tek". 92 73

Renal function studies were done on asymptomatic hyperuricemic subjects and normouricemic controls matched as to age, sex and blood pressure. Abnormal urinary sediments and proteinuria were found more frequently in asymptomatic hyperuricemic subjects than in the controls. In addition, the maximal osmolar concentrating ability of urine was markedly reduced in the asymptomatic hyperuricemic subjects. There was no difference in renal function measured by phenolsulfonphthalein excretion between the groups. Our results suggest that hyperuricemia alone may contribute to renal tubular impairment.
J Urol 1977 Dec
PMID:Tubular function impairment in patients with asymptomatic hyperuricemia. 92 61

This autosomal dominant disorder usually appears in middle life. The most common findings are proteinuria, abdominal pain and palpable kidneys, followed by hematuria, hypertension, pyuria, uremia and calculi. In 15% of patients, death is due to cerebral aneurysm. Family counseling and the detection of "at risk" family members are important elements of management. Statistically, half of the offspring of one affected parent will have the disease.
Am Fam Physician 1977 Dec
PMID:Polycystic kidney disease. 93 Aug 6

The blood levels of 25-hydroxyvitamin D (25-HCC) in 26 patients with nephrotic syndrome (proteinuria of 6.5 g/24 h +/- 0.8 SEM) ranged between 1 and 18.6 ng/ml (8.6 +/- 1.0 SEM). This value was significantly lower (P less than 0.01) than that in normal subjects (21.8 +/- 2.3 ng/ml) and patients with chronic renal failure (24.8 +/- 2.3 ng/ml). There was inverse correlation (P less than 0.01) between levels of 25-HCC and magnitude of proteinuria and a direct relation (P less than 0.01) with serum albumin. Reduction in proteinuria was rapidly followed by a rise in blood 25-HCC toward normal. Ionized calcium levels were low in 16 of 26 nephrotic patients irrespective of degree of renal failure. In four of seven nephrotic patients with normal renal function, ionized calcium levels were low and showed an inverse relation with levels of parathyroid hormone. These data show that patients with nephrotic syndrome have low blood levels of 25-HCC probably due to its loss in urine. This derangement is probably responsible for the disorders of calcium metabolism in nephrosis.
Ann Intern Med 1977 Dec
PMID:Blood levels of 25-hydroxyvitamin D in nephrotic syndrome. Studies in 26 patients. 93 Dec 2

Certain hemodialysis patients need to be made anephric, either surgically or physiologically. Bilateral renal infarction with shredded absorbable gelatin sponge (Gelfoam) was performed on a woman with malignant hypertension being maintained on chronic center dialysis who was too great a surgical risk for bilateral nephrectomy. Peripheral embolization complicated the procedure resulting in a forefoot amputation for dry gangrene two months later. Her postinfarction peripheral plasma renins remained elevated, and she remained hypertensive but was more easily managed with fewer drugs. This technique has been successfully used by others in 1 patient with chronic renal failure and heavy proteinuria and another with hypertension and a solitary kidney. If, as in our case, postinfarction plasma renins remain elevated and hypertension persists, bilateral nephrectomy could be performed at a later date or infarction could be repeated.
Urology 1976 Dec
PMID:Treatment of uncontrolled hypertension by therapeutic renal infarction. 99 56

A prospective study of 10,074 white gravidas and 2,880 black gravidas carried out during the years 1959 to 1967 has been analyzed with respect to the impact of elevated blood pressures and/or proteinuria upon pregnancy outcome. Edema was not considered because no evidence is available to indicate that its occurrence increases risk. The mean arterial pressure exhibited during the fifth and sixth months of pregnancy was found to be of significance, as well as the absolute levels of blood pressure attained prior to labor and delivery. The degree of rise in blood pressure was not of importance in itself. However, categories with significant proteinuria had greater increases in mean arterial pressure than did comparable categories without it. Significant proteinuria alone but especially with hypertension was also detrimental to pregnancy outcome. Eight categories incorporating early and late hypertension with and without proteinuria were created, and these were given descriptive diagnostic labels. Only "gestational hypertension," as defined, proved to be essentially devoid of risk to the fetus. In all other non-normotensive categories there was an increase in the stillbirth rate, the perinatal mortality rate, the frequency of intrauterine growth retardation, and neonatal morbidity. In every category, each of these untoward events was greater in black than in white gravidas, and a higher percentage of blacks was noted in each of the hypertensive categories. It is believed that hypertension, significant proteinuria, or both are associated with decreased uteroplacental blood flow which is the common denominator for all of these deleterious effects. The study suggests that "gestational hypertension" occurring late but without proteinuria may or may not represent an early stage of "pre-eclampsia" but does not, at least, place the infant at any substantially increased risk.
Am J Obstet Gynecol 1976 Dec 01
PMID:Influence of blood pressure changes with and without proteinuria upon outcome of pregnancy. 99 75

The intraperitoneal injection of 1 g of bovine serum albumin daily for 5 days was shown by electron-microscope morphometry to cause swelling of the glomerular epithelial cells and very severe loss of foot processes. However, these changes were found in only 70 per cent. of glomeruli and the other 30 per cent. remained normal. After 7 days' recovery following five daily injections of 1 g of bovine serum albumin, the swelling of the glomerular epithelial cells had subsided and the foot process reappeared. These changes were accompanied by severe proteinuria which resolved only slowly when the injections were stopped. After daily injections of 0-8 g of egg albumin for 5 days there was no swelling of the glomerular epithelial cells and only very slight loss of foot processes detectable only by morphometry. There was a less severe proteinuria than after injections of bovine serum albumin and it resolved more rapidly when injections were stopped. It is suggested that these differences arise from the fact that bovine serum albumin is reabsorbed by the glomerular epithelial cell but egg albumin is not. Two of four rats allowed to recover for 7 days after five daily injections of 1 g of bovine serum albumin had unusual glomerular lesions.
J Pathol 1976 Dec
PMID:The morphometry of the glomerular epithelial cell and its foot processes after the injection of bovine serum albumin or egg albumin. 101 Oct 57


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