Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Eighty-nine patients with onset of nephrotic syndrome over the age of 15 years and minimal changes on renal biopsy have been studied. Seventy-five patients were given a course of prednisone in an initial dosage of 60mg/24hr, tapering over the following 8-16 weeks. Only 45 were in remission after eight week's treatment, 55 after 16 weeks; eventually, a total of 58 lost their proteinuria completely. Of these, 24 per cent never relapsed, 56 per cent relapsed on a single occasion or infrequently, and only 21 per cent were frequent relapsers. Cyclophosphamide, used in 36 patients, had a similar time to response. Stability of remission was better than in similar children, 66 per cent being in remission at five years, after which no further relapses were seen.
Proc Eur Dial Transplant Assoc Eur Ren Assoc 1985
PMID:Adult-onset nephrotic syndrome with minimal changes: response to corticosteroids and cyclophosphamide. 399 49

To evaluate the role of renal haemodynamic factors in the pathophysiology of diabetic nephropathy, we determined by radionuclear techniques glomerular filtration rate (GFR) and renal plasma flow (RPF) in 18 patients affected by insulin dependent diabetes mellitus (IDDM) in good metabolic control, with normal blood pressure and plasma creatinine. GFR and RPF measured in the same patients after ten months correlated with proteinuria and duration of diabetes. Our finding of a significant correlation between the decline of RPF and duration of diabetes may support the haemodynamic hypothesis of progression of diabetic nephropathy.
Proc Eur Dial Transplant Assoc Eur Ren Assoc 1985
PMID:Radionuclear determination of glomerular filtration rate and renal plasma flow to detect early decrease of renal function in insulin dependent diabetes. 399 57

Six HBsAg negative patients with cirrhosis of the liver (CL) presented with recurrent bouts of palpable purpura in the legs due to small vessel leucocytoclastic vasculitis. In addition, all patients had renal failure, proteinuria and microhaematuria. Renal biopsy disclosed either diffuse proliferative (3 cases) or focal necrotising glomerulonephritis with crescents (2 cases). One patient had IgM-IgG mixed cryoglobulinaemia (type II). Four patients died of complications of their CL. Hepatocellular carcinoma was found in 1 case. In the patient without renal biopsy renal function improved following steroids and cyclophosphamide. The pathogenesis of this syndrome of cutaneous vasculitis with severe glomerular involvement in CL is unknown but could be immune-complex mediated.
Proc Eur Dial Transplant Assoc Eur Ren Assoc 1985
PMID:Renal involvement in a syndrome of vasculitis complicating HBsAg negative cirrhosis of the liver. 399 59

Colchicine has been used since 1972 to prevent the acute attacks of familial Mediterranean fever. The present study shows that colchicine is also effective in the prevention of amyloidosis. If initiated in patients without evidence of renal disease there is no appearance of proteinuria and no progression to renal insufficiency over long follow-up periods. Moreover, it ameliorates the course of the disease in patients with amyloid nephropathy and normal renal function. It does not alter the course of the disease if initiated after renal function is even mildly impaired. These findings suggest that colchicine prevents the new deposition of amyloid.
Proc Eur Dial Transplant Assoc Eur Ren Assoc 1985
PMID:The prevention of amyloidosis in familial Mediterranean fever with colchicine. 399 64

Renal plasma flow (RPF) and glomerular filtration rate (GFR) were estimated by 125I hippuran and 51Cr EDTA clearances using a single shot technique on two occasions at one-year intervals in 22 patients fulfilling the ARA criteria for systemic lupus erythematosus (SLE). All these patients had histologically proven renal disease. Filtration fraction was a better parameter than proteinuria, urinary sediment or GFR for recognising diffuse proliferative glomerulonephritis with a sensitivity of 61 per cent and a specificity of 88 per cent. After one year all the patients with an initially low filtration fraction (FF) had significantly changed their GFR, which demonstrates that this parameter indicates the presence of an active renal lesion.
Proc Eur Dial Transplant Assoc Eur Ren Assoc 1985
PMID:Filtration fraction: an index of renal disease activity in patients with systemic lupus erythematosus. 399 66

The effect of continuous subcutaneous insulin infusion on renal function was studied in 12 patients with insulin-dependent diabetes mellitus. Serum creatinine was less than 110 mumol/L in all patients. Total urinary protein excretion was less than 250 mg/24 hr in seven patients (group I) and exceeded 0.5 g/24 hr in five (group II). Initial glomerular filtration rate was higher in group I compared with group II: 136.0 +/- 8.5 ml/min versus 103.2 +/- 4.6 ml/min (mean +/- SEM; p less than 0.02). After one to three months pump therapy glomerular filtration rate decreased in both groups. It remained stable during 32-36 months in group I (126.3 +/- 6.1, and 127.9 +/- 7.7 ml/min, respectively) but deteriorated in group II (98.6 +/- 4.4, and 60.0 +/- 6.8 ml/min, respectively; p less than 0.01 compared with group I). These results indicate that strict blood glucose control with continuous subcutaneous insulin infusion does not prevent deterioration of renal function in type I diabetic patients with clinical proteinuria. This suggests that other factors than metabolic control are involved in the course of diabetic nephropathy.
Proc Eur Dial Transplant Assoc Eur Ren Assoc 1985
PMID:The effect of continuous subcutaneous insulin infusion on renal function in type I diabetic patients with and without proteinuria. 399 67

Generalised sepsis was induced in sheep by caecal perforation. Serial measurement of haemodynamic parameters revealed that the subsequent generalised sepsis induced increased cardiac output and decreased systemic resistance comparable to that known to occur in man. Glomerular filtration rate in these animals fell significantly 48 hours after induction of sepsis and there was evidence of tubular damage in the finding of low molecular weight proteinuria and increased clearance of lysozyme. Pathological examination of the kidney revealed normal glomeruli, no consistent changes in tubular cells on light microscopy, negative immunofluorescence, but structural changes in proximal tubular cells on EM. In this model, non-hypotensive sepsis predictably produces damage to proximal tubular cells accompanied by reduction in GFR.
Proc Eur Dial Transplant Assoc Eur Ren Assoc 1985
PMID:Acute renal failure and tubular damage due to sepsis in an animal model. 399 81

The type of proteinuria and renal selectivity of glycosyl albumin has been evaluated in seven diabetic patients at the onset of plasma hyperosmolar state and after complete fluid replacement. The main feature of all patients was a marked increase in urinary excretion of beta 2-microglobulin, which promptly returned to normal after the correction of the fluid disequilibrium. This indicates that a reversible tubular injury is the first symptom of the dehydration process in diabetic patients with plasma hyperosmolality.
Proc Eur Dial Transplant Assoc Eur Ren Assoc 1985
PMID:Tubular function and renal selectivity towards glycosyl-albumin in diabetic hyperosmolar states. 399 86

Renal biopsy was performed in 20 graft recipients to characterise the histological features associated with poor renal function concomitant with cytomegalovirus infection (CMV). Eight patients presented with proteinuria, three had microscopic haematuria at onset, and five were hypertensive. Infection was accompanied by clinical symptoms (fever, leucopenia, mild hepatic damage, or pneumonitis) in 15 patients. In all cases, serum creatinine was greater than 2 mg/dl. All patients showed some glomerular alteration on biopsy, and vascular changes were the predominant feature in seven cases. IgM and complement (C3) were found in the glomeruli of five of six patients studied by immunofluorescence. Serum creatinine was below 2 mg/dl at ten to 26 months following the infectious episode in four patients and between 2-3 mg/dl in three patients. The remaining 13 developed irreversible rejection and end-stage renal failure. We conclude that CMV, the most commonly recognised viral infection following transplantation, can cause renal changes, both glomerular (CMV glomerulopathy) and vascular (transplant vasculopathy), which may induce poor graft function.
Proc Eur Dial Transplant Assoc 1983
PMID:Renal changes in cytomegalovirus infection. 630 1

A proliferative glomerulonephritis was induced in rats preimmunised with rabbit IgG by injecting a sub-nephrotoxic dose of rabbit anti-rat GBM IgG. All the rats developed a severe proteinuria within 2-5 days after the injection of anti-GBM IgG. At the same time, many mononuclear phagocytes infiltrated the glomeruli, the colloidal iron staining of the glomerular filtration barrier was altered, and the urinary excretion of laminin and of neutral proteinase strongly increased. However, the pattern and intensity of staining of different collagenous and non-collagenous BM glycoproteins were not modified, as shown by indirect immunofluorescence microscopy. The existence of a direct significant correlation between the proteinuria and the laminin urinary excretion, and between the latter and the urinary neutral proteinase activity suggests that lysosomal proteinase of mononuclear phagocytes may be involved in the damage of the GBM during the course of this experimental glomerulonephritis.
Proc Eur Dial Transplant Assoc 1983
PMID:Studies on the glomerular filtration barrier and on the urinary excretion of basement membrane glycoproteins during the accelerated model of nephrotoxic serum nephritis. 636 61


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