Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0033687 (
proteinuria
)
24,015
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The purpose of the study was to determine if danazol was efficacious in the treatment of lupus MRL/MpJ (lpr) mice, as measured by longevity,
proteinuria
and serum amyloid protein (SAP) levels.
Danazol
, administered at an oral dose of 100 mg/kg, significantly prolonged survival of female MRL/MpJ (lpr) mice but had no effect on the mortality of their male counterparts. Medication with danazol began 40 days after birth of the mice and resulted in a significant decrease in
proteinuria
in female but not male lupus mice. The concentration of SAP, an acute phase reactant, was significantly decreased in danazol-treated female lupus mice at 80, 100, 120, 140 and 160 days of age when compared to vehicle-treated control mice. SAP levels in male lupus mice treated with danazol were significantly lower than normal control levels only at the 120 and 160 day time points. Measurements of mortality,
proteinuria
and SAP concentration indicate that danazol at 100 mg/kg is orally active in the treatment of MRL/MpJ (lpr) female, but not male mice.
...
PMID:The effect of danazol in the MRL/lpr mouse model of autoimmune disease. 318 43
Endometriosis of the bladder is an uncommon disease, but is common in gynecology. A 34-year-old woman visited us to be explored for the cause of microscopic hematuria and
proteinuria
, but gross hematuria had never been observed. Cystoscopic examination revealed a great number of pea size, hemispheric cysts on the trigone and the posterior wall of the bladder. Histopathological examination of the specimen taken by TU-biopsy showed vesical endometriosis.
Danazol
(17 alpha-Pregna-2, 4-dien-20-yno[2,3-d] isoxazol-17-ol) was given to induce menostasia and thereafter endoscopic findings and subjective symptoms were improved. Seventy-five cases of vesical endometriosis in the Japanese were reviewed.
...
PMID:[A case of vesical endometriosis]. 668 8
