Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Long-term administration of acetohydroxamic acid to dogs with experimentally induced urease-positive staphylococcal urinary tract infections and struvite urolithiasis resulted in dose-dependent inhibition of urolith growth or urolith dissolution. Inhibition of urolith growth was associated with drug dose-dependent reduction of urine urease activity, urine pH, crystalluria, pyuria, hematuria, and proteinuria. Lesions of the urinary tract of dogs treated with acetohydroxamic acid were less severe than those of control dogs. Dose-dependent adverse drug reactions included reversible hemolytic anemia, abnormal red cell morphology, and abnormalities of bilirubin metabolism.
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PMID:Effect of acetohydroxamic acid on dissolution of canine struvite uroliths. 2404 82

Long-term administration of acetohydroxamic acid (AHA) to dogs with experimentally induced urease-positive staphylococcal urinary tract infections, and bladder zinc disk foreign bodies inhibited urolith growth in 2 dogs and prevented urolith growth in 4 dogs. Inhibition and prevention of urolith growth were associated with reduction in urine urease activity, crystalluria, pyuria, hematuria, and proteinuria. Lesions in the urinary tract of AHA-treated dogs were less severe than those of infected control dogs. Administration of AHA for 6 months induced mild morphologic abnormalities in RBC, but did not cause hemolytic anemia.
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PMID:Effect of acetohydroxamic acid on prevention of canine struvite uroliths. 2404 83