Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The participation of renal prostaglandins in the nephrotic syndrome has been investigated by the measurement of the urinary excretion of prostaglandin E2 (PGE2), renal function and the renin-angiotensin-aldosterone system before, during and after the administration of indomethacin in a group of patients diagnosed as having chronic idiopathic glomerulonephritis with and without nephrotic syndrome. Our results indicate increased renal production of PGE2 in nephrotic patients. This contributes to the maintenance of renal function, probably by counteracting an activated renin-angiotensin system and could be accompanied by a simultaneous and deleterious enhancement of the degree of proteinuria. Nevertheless, the participation of angiotensin II in this last even cannot be excluded.
Proc Eur Dial Transplant Assoc 1983
PMID:Participation of renal prostaglandins in the nephrotic syndrome. 657 32

The effects of thymus factor (TFX) and levamisole on the clinical picture and some indices of cellular immunity have been evaluated in 10 patients with nephrotic syndrome due to membranoproliferative glomerulonephritis Type I. The patients revealed decreased T-lymphocyte number and impaired responsiveness to phytohaemagglutinin (PHA) stimulation before treatment. An association between the slight diminution of proteinuria and the increase of E-rosette forming lymphocytes, increased responsiveness to PHA and return to normal of previously elevated B-cell percentages, was observed in four patients treated with TFX and one patients treated with levamisole.
Proc Eur Dial Transplant Assoc 1983
PMID:Effect of thymus factor and levamisole treatment in patients with persistent nephrotic syndrome. 660 17

In a study of 124 patients with systemic amyloidosis, renal involvement was the major presenting feature in 68 per cent of patients with AA and 42 per cent with AL disease. Renal failure contributed to the deaths of 72 per cent and 33 per cent of patients respectively. In 23 renal biopsies from patients with AA disease, quantitative glomerular amyloid infiltration correlated with urinary protein excretion and with serum creatinine. Seven of these patients had repeat biopsies; change in glomerular amyloid correlated with changes in both renal function and proteinuria. Four patients with end-stage renal amyloidosis have been successfully managed on CAPD for 37 patient months.
Proc Eur Dial Transplant Assoc 1983
PMID:Renal involvement in systemic amyloidosis. 665 78

The role of the immune system in the progression of experimental nephrotoxic serum nephritis (NTN) in rats has been evaluated. Proteinuria and renal functional impairment during the sub-acute phase of the disease determined the long-term prognosis of the nephritis regardless of the humoral autologous antibody levels. In contrast to the acute, immune mediated glomerulonephritis, chronic glomerular scarring in NTN proceeds independently of the host immune response.
Proc Eur Dial Transplant Assoc 1983
PMID:Acute and chronic nephritides: two different diseases? 665 82

In three unrelated kindreds, 21 subjects with hereditary renal disease were identified. The mode of inheritance was autosomal dominant and the main clinical features were asymptomatic proteinuria and/or haematuria. Three of the 16 females but none of the five males developed progressive renal failure. Renal biopsy carried out in six of the 21 patients showed varying degrees of mesangial change with glomerular deposition of IgM and C3 in some cases. Nerve deafness and renal ultrastructural changes typical of Alport's Syndrome were absent. The renal disease in these subjects does not conform with previously recognised types of familial nephropathy.
Proc Eur Dial Transplant Assoc 1983
PMID:Hereditary glomerulonephritis of non-Alport type. 687 56

Administration of prednisone to patients with nephrotic syndromes of different aetiologies caused an abrupt increase of proteinuria. The proteinuric effect started four hours after oral or intravenous administration and reached its maximum effect after eight to sixteen hours. In nine patients with epimembranous glomerulopathy mean proteinuria on non-prednisone (NP) days was 43.7 per cent lower than on prednisone (P) days. Variations were significantly greater at higher creatinine clearances. However, in individual patients there were neither differences in creatinine excretion nor in creatinine clearance between P and NP days.
Proc Eur Dial Transplant Assoc 1983
PMID:Prednisone-induced increase of proteinuria in patients with a nephrotic syndrome. 687 66

Plasmapheresis (PE) was used in the treatment of three patients with biopsy proven mesangiocapillary glomerulonephritis (MCGN) of acute onset and renal failure. The percent of glomeruli with extracapillary proliferation varied from 40 to 90 per cent. Following PE, there were reductions in serum creatinine of 66 per cent, 61 per cent and 82 per cent in patients, one, two and three respectively. Plasmapheresis proved effective in a second episode of renal failure in patient three. After the completion of PE, renal function has remained stable in all patients for periods ranging from two to 12 months. However, haematuria and heavy proteinuria persist in every case. PE appears to facilitate recovery from renal failure in MCGN of acute onset, possibly by removing circulating mediators of acute inflammatory glomerular damage.
Proc Eur Dial Transplant Assoc 1983
PMID:Plasmapheresis induced recovery from renal failure in mesangiocapillary glomerulonephritis of acute onset. 687 67

We report the use of the orally active converting enzyme inhibitor Captopril in hypertensive patients with mild chronic renal failure. Twenty eight patients were followed for a period of six months. Eleven patients required the addition of furosemide. Mean arterial pressure (MAP) decreased in all but two at six months (MAP: 102 +/- 0.8 vs 133 +/- 2.2mmHg, p less than 0.001). Untoward effects were frequent: the commonest reactions are loss of taste (four patients), skin rashes (11 patients), proteinuria (2 patients), tachycardia (2 cases). These side effects disappeared after reduction of dose (10 cases) or withdrawal (8 cases). Patients on 300mg daily or less were free of any untoward effect. In summary (i) Captopril alone or in combination with furosemide has an antihypertensive effect in patients with chronic renal failure and hypertension; (ii) side effects seem to be dose dependant and a reduced dosage should be used in these patients.
Proc Eur Dial Transplant Assoc 1980
PMID:Long term effect of captopril in hypertension with chronic renal failure. 701 4

Four patients with acute renal failure due to myeloma (IgG with lambda, lambda, lambda, IgG with kappa) were studied; serum creatinine was 4.7, 5.9, 4.25, 10.8 mg%, and proteinuria 2.1, 2.8, 5.2, 4.2g/24h respectively. Renal biopsy specimens (3 patients) showed interstitial fibrosis, oedema, infiltration of mononuclear cells, tubular atrophy or dilatation with many 'myeloma kidney' casts. The patients were treated with plasmapheresis (2-4 exchanges) and methylprednisolone pulses (three to four 1g pulses). Maintenance therapy included prednisone, vincristine, melphalan and cyclophosphamide. After a follow up of 26, 17, 8, 6 months respectively, serum creatinine levels are 1.7, 2.4, 1.8, 4.2mg% respectively. Proteinuria disappeared after three months of therapy in 3 patients, and then remained absent for the successive follow up.
Proc Eur Dial Transplant Assoc 1980
PMID:Steroid pulses and plasmapheresis in the treatment of acute renal failure in multiple myeloma. 724 8

Twenty-six cases of Mesangial Proliferative Glomerulonephritis and diffuse IgM deposits were studied. Nine had nephrotic syndrome; 8 minimal urinary abnormalities; 7 asymptomatic proteinuria; 2 recurrent haematuria. Immunofluorescence revealed granular mesangial deposits in 14 cases and interrupted linear deposits in the others, chiefly along the capillary walls. In the latter group the clinical picture was mainly nephrotic syndrome or asymptomatic proteinuria. The clinical course is favourable: 7 cases recovered; 12 improved; 7 did not show any change. No progression of renal lesions was observed. Despite uniform histological features, this nephropathy is unlikely to be a unique disease, but in our opinion it should be considered separately from other glomerulopathies.
Proc Eur Dial Transplant Assoc 1981
PMID:Long term study of mesangial proliferative glomerulonephritis with IgM deposits. 732 78


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