Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 67-year-old man was hospitalized with a diagnosis of nephrotic syndrome. Physical findings at admission were generalized edema and macroglossia. Urinalysis showed massive proteinuria, + +occult blood, and granular and broad casts. Ig A lambda monoclonal gammopathy was noted in the serum. There was no evidence of myeloma in the bone marrow aspirate, scintigram or X-ray of the bone. A biopsy specimen of the kidney showed massive deposits of structureless material in the glomeruli. Marked cell infiltration was also observed in the interstitium. Multinucleated giant cells were occasionally seen in the Bowman's capsules and the interstitium. There were reactive changes in the Bowman's capsule adjacent to the giant cell. The deposits were proved to be amyloid by positive staining with Congo red and apple-green birefringence by polarized light. In addition, microfibrills seen on electron microscopy displayed deposits. Amyloid depositions were observed in other tissues such as gingiva, skin and tongue. Staining of amyloid with Congo red was resistant to potassium permanganate, and amyloid was positively stained with lambda-light chain of immunoglobulin. These findings indicated that the patient had primary amyloidosis. Infiltration of the multinucleated giant cell has been reported only in patients with familial amyloidosis and secondary amyloidosis associated with rheumatoid arthritis. To our knowledge the present case is a first report of the giant cell infiltration in a Bowman's capsule in primary amyloidosis.
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PMID:[A case of primary amyloidosis associated with giant cell infiltration within a Bowman's capsule]. 147 13

A 9-year-old boy developed acute renal failure following intravenous acyclovir (30 mg/kg per day) administered for 6 days to treat herpetic encephalitis. Physical findings and urine output were normal, except for increasing blood urea nitrogen (BUN), serum creatinine and mild proteinuria. Acyclovir was discontinued. However BUN and serum creatinine continued to increase and peaked on the following day at 8.6 mmol/l of urea (24 mg/dl) and 194 mumol/l (2.2 mg/ml), respectively. Conservative treatment and hydration were carried out. The kidney function returned to normal within 1 week. The use of acyclovir when necessary in renal failure patients is discussed.
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PMID:Acute renal failure in a child associated with acyclovir. 763 29

The diagnosis of preeclampsia is made on the basis of hypertension, proteinuria and edema. Unfortunately, all three of these findings can be seen in the patient who is experiencing a flare of systemic lupus erythematosus. The management of these conditions is entirely different. Preeclampsia frequently results in the need for delivery and occasionally, especially when remote from term, can result in significant neonatal morbidity and mortality. Systemic lupus may be treatable with a variety of pharmacologic agents. It is not always possible to make the distinction between active lupus and preeclampsia, and occasionally the two occur concurrently. Nevertheless, the goal of the rheumatologist and perinatologist is to try to make that distinction. Physical findings and serologic markers can be useful in helping to distinguish between these two diagnoses. Under certain circumstances, delivery is indicated despite the presence of continued uncertainty as to the actual diagnosis.
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PMID:Hypertensive disorders of pregnancy. Differentiating preeclampsia from active systemic lupus erythematosus. 958 67