Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 35-year old male patient who, since the age of 17, had membranoproliferative glomerulonephritis presented with recurrent atopic eczema and sinusitis. Outbursts of eczema, sinusitis and proteinuria occurred simultaneously. Signs of immune deficiency, with permanently extreme IgE levels (greater then 10.000 I.U/ml), defective neutrophil chemotaxis and monocyte phagocytotic function (Buckley's syndrome) were present. The role of these abnormalities in the pathogenesis of glomerulonephritis (chronic antigen production associated with focal infection and resulting in the formation of immune complexes, defective elimination of these circulating immune complexes) is discussed.
 ...
PMID:[Hyperimmunoglobulinemia E syndrome with recurrent infections (Buckley's syndrome) associated with membranoproliferative glomerulonephritis. A case in an adult]. 622 Dec 61