Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The case reports of late primiparae greater than 35 years of age were analysed in respect of the change of anamnestic risks, of the course of pregnancy, birth and puerperium, as well as of infant data. The incidence of late primiparae rose in our clinic from A 1.8% (n = 292, infants n = 294), via B 2.6% (n = 210, infants n = 213) to C 3.7% (n = 222, infants n = 225.) Previous history of internistic diseases was rare during all periods. In period C, the anamnestic risk "Status after sterility treatment" attains increasing importance (17%). The incidence of pre-eclamptic toxaemia (toxaemia associated with oedema, proteinuria and hypertension) with blood pressure levels greater than 140/90 mgHg and proteinuria greater than 1 0/00 is 5-7% for all periods. Preeclampsia and eclampsia are rare. During the C period, almost every tenth late primigravida received tocolytics. In 1979, 31% of the late primiparae were subjected to genetic amniocentesis, whereas in 1982 the percentage was 51% of the late primiparae. Spontaneous deliveries decreased from 81% (A) to 50% (C). The rates of Caesarean sections increased from 11% (A) via 21% (B) to 35% (C); hence, they were twice as high during all periods than among the entirety of hospital patients included in this study. The increase in the quota of Caesarean sections is due to the indications "foetal distress ante partum", "breech presentation" and the liberal use of Caesarean section in underweight infants. For example, the category of newborn with a bodyweight below 2500 g, the rate of Caesarean sections increased from 7% (A) to 56% (C).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Late primiparity: what has changed in the last 25 years?]. 656 34

Preeclampsia and eclampsia are very important health problems because they are the main contributors to maternal and perinatal morbidity and mortality. These disorders are unique in pregnancy and are characterized by oedema, proteinuria and hypertension. they occur in 0.5% to 30% of all pregnancies, primarily in primigravidas, after the 20-th week of gestation. Preeclampsia and eclampsia are diseases of undetermined cause. Many different factors might play an important role in the development of these diseases. One of them is nutrition. Recent studies have emphasized the possible role of general nutritional deficiency or imbalance of several specific nutrients in the aetiology of the disease. Deficiency of a variety of nutrients has been reported in patients with preeclampsia. The obtained results are contradictory and further study is necessary. Nevertheless, some evidence is highly suggestive of a relationship between nutritional status and the onset or progress of the disease. The article reviews the study that correlates the role of several nutritional elements with the pathophysiology of preeclampsia and eclampsia: proteins, lipids, calcium, vitamin D, sodium, magnesium and zinc. The evidence that supports or rejects the role of each of these nutrients is presented. In this way a guideline for general nutritional counseling in the prenatal period that will promote a healthier pregnancy, is offered.
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PMID:[The role of nutritional factors in pre-eclampsia and eclampsia]. 910 38

Preeclampsia and eclampsia account for major pregnancy complications in Mauritius, an emerging country (maternal mortality rate of 60 per 100,000 deliveries). This prospective longitudinal study was carried out in the main regional hospital in the north of the island, to measure inositol phosphoglycan-P type (IPG-P) in the urine of pregnant women (using an ELISA-based assay). Women had approximately 10 prenatal visits per pregnancy and a complete follow-up in this same referral centre after the first trimester of pregnancy. Urine samples were collected every 1-4 weeks in all women. In a cohort of 416 patients, preeclampsia (PE) was diagnosed in 34 women. In established PE (hypertension and proteinuria), the assay as a diagnostic test showed a positive likelihood ratio of 18.73, a negligible negative likelihood ratio with area under the curve (AUC) of 0.99, sensitivity of 96.7%, specificity of 94.8% and remained negative in control women (n=312), women with gestational hypertension (without proteinuria (n=56), and gestational diabetic mothers (n=14). Moreover, as a predictive screening test two weeks before the diagnosis of PE, the assay showed sensitivity of 84.2% and specificity of 83.6%. Detection of urinary inositol phosphoglycan-P type in pregnant women can be a useful confirmatory marker of PE, as well as a predictive marker, two weeks before the onset of the disease.
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PMID:Urinary inositol phosphoglycan-P type: near patient test to detect preeclampsia prior to clinical onset of the disease. A study on 416 pregnant Mauritian women. 2396 12

Preeclampsia and eclampsia continue to be major contributors to maternal mortality and morbidity. Lack of appreciation for the multi-organ involvement of preeclampsia, combined with overly rigid criteria for diagnosis, may hinder early diagnosis and appropriate management. Recently, the American College of Obstetricians and Gynecologists Task Force on Hypertension in Pregnancy evaluated the evidence and formulated new recommendations for diagnosis and management. This article reviews some of these recommended changes, including the new classification of the hypertensive diseases of pregnancy. Systolic blood pressure has been shown to be as important as diastolic blood pressure in the diagnosis of preeclampsia. Changes in proteinuria are not predictive of disease severity or maternal or fetal complications; therefore, the magnitude of proteinuria or changes in the amount should not dictate diagnosis or management. Instead, symptoms of cerebral involvement, such as headache and visual changes or signs of end-organ involvement including abnormal laboratory tests (elevated serum creatinine or liver function tests, low platelet count), are evidence of preeclampsia with severe features. Immediate induction of labor is recommended for women with gestational hypertension or preeclampsia at 37 weeks' gestation or later. Pregnant and postpartum women need to know important warning signs and symptoms of preeclampsia. Prompt diagnosis of preeclampsia and appropriate management will improve the quality of care for women.
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PMID:Major changes in diagnosis and management of preeclampsia. 2537 51

Preeclampsia is an entity that may present from 20th week of gestation up to 48 hours postpartum and is associated with hypertension and proteinuria. Eclampsia is emergence of convulsions pre-eclampsia in pregnant women with signs and symptoms. Recent studies showed that in some women, preeclampsia and even eclampsia may occur without hypertension or proteinuria. Here, we present a case of 26 years old women who had an uneventful pregnancy until 30 weeks' of gestation. She had only proteinuria in laboratory tests and was diagnosed as status epilepticus in early postpartum period. Preeclampsia and eclampsia is related with serious fetal and maternal morbidity and mortality and may present with atypical course. The awareness of atypical cases of preeclampsia enhances early diagnosis and management which are critical to avoid feto-maternal complications.
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PMID:Atypical eclampsia and postpartum status epilepticus. 2599 14