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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Babesia microti-like piroplasms are a recently recognized cause of illness in dogs in northwest Spain. Our objective was to describe the clinical characteristics and investigate the risk factors for azotemia and death among 58 B microti-like infected dogs. Twenty-one of the 58 (36%) dogs were azotemic at the time that the infection was diagnosed. The case fatality rate during the following week was 22%. Dogs with azotemia at the time of diagnosis were 10 times (95% CI, 3.26-28.8) more likely to die during the following week. Azotemia was the main cause of death for B microti-like infected dogs (attributable fraction = 90%). Severe anemia was present in 45 of the 58 (78%) dogs. Azotemic dogs also presented with hyperphosphatemia, hypoalbuminemia, hypercholesterolemia, proteinuria, and high urine protein: creatinine ratios, suggesting a glomerular component to the disease. Age was the only factor significantly associated with the risk of azotemia (P = .042): on average, a 4-year age increase doubled the risk of an infected dog being azotemic. The only factor significantly associated with mortality was azotemia (P = .001). We concluded that B microti-like infection is associated with a high risk of azotemia and mortality.
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PMID:Azotemia and mortality among Babesia microti-like infected dogs. 1505 62

Nineteen cattle with pyelonephritis were examined sonographically. A 3.5- and 5.0-MHz convex transducer was used for percutaneous and a 5.5-MHz linear scanner for transrectal examination. Ultrasonographic changes included enlarged kidneys, echogenic material, and flocculent fluid within a dilated and deformed renal sinus and a poor cortical medullary differentiation. Azotemia was detected in 10 and hematuria and proteinuria in all animals. Microbial culture revealed Corynebacterium renale in eight and Escherichia coli in five cattle. Sonography supplemented the clinical examination and clinicopathological analysis by providing additional information on renal disease in these patients.
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PMID:Sonographic application in the diagnosis of pyelonephritis in cattle. 1723 64

The paper shows the morphological findings of and clinical and demographic data on 61 patients with nonamyloid form of renal monoclonal immunoglobulin deposition disease (MIDD) unassociated with amyloidosis and/or Bence-Jones nephropathy: 40 cases of light-chain deposition disease, 18 cases of light-and-heavy- chain deposition disease (LHCDD) and 3 cases of heavy-chain deposition disease (HCDD). According to the composition of paraprotein deposits, the cases were distributed as follows: k (30), lambda (10), IgG/k (6), IgA/k (6), IgG/lambda (4), IgA/lambda (2), and IgA/gamma (3). Light microscopy revealed three variants of the glomerular structure: diffuse nodular glomerulopathy (42.6%), diffuse mesangeal dilation (27.9%), and inract glomeruli (29.5%). Varying severity of tubular atrophy was noted in 95% of cases. Tubular, glomerular, and smooth muscle basement membrane deposits substantially differed in immunofluorescent (100%, 91.8% and 54.1%) and ultrastructural studies (55.7%, 45.9%, and 4.9%, respectively). Azotemia (68.9%) and proteinuria (55.8%) were most commonly revealed. The incidence of nephrotic syndrome concurrent with severe proteinuria was 27.9%.
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PMID:[Morphological characteristics of the non-amyloid form of renal monoclonal immunoglobulin deposition]. 1729 Aug 87

Nineteen adults who had acute glomerulonephritis were reviewed with respect to the clinical course and long-term follow-up. The age range was from 17 to 55 years. Only one patient died during the acute episode. In 11 cases, onset occurred between November and January and 15 of the patients had a known respiratory tract infection three to 30 days before the onset. The most important symptoms noted were weight gain, edema, dyspnea, oliguria and red or smoky urine. The most prominent physical signs were elevated blood pressure, edema, abnormalities in the chest and fever of over 100 degrees F. Fifteen patients showed roentgen evidence of pulmonary vascular congestion, pleural effusion, cardiomegaly, pneumonia or a combination of these abnormalities. All the patients had proteinuria and red blood cells in the urine, and half of them had red blood cell casts. Azotemia, when present, subsided in 9.4 days. The average diastolic pressure was 105 mm. of mercury and the mean fall was 26 mm. in 23.5 days. At six months, nine of the 13 patients still being observed continued to show proteinuria or microscopic hematuria (seven showed both). A late follow-up of ten patients showed one to have significant hypertension and one to have early functional impairment and inconstant proteinuria. In these cases the average blood pressure was 140/91 mm. as compared with 119/74 mm. at the time of discharge. Sporadic glomerulonephritis in adults presents essentially the same pattern as it does in children. Urinary abnormalities may persist for months or even years, and neither the present series nor those reported by others clearly reveal the ultimate prognosis.
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PMID:SPORADIC ACUTE GLOMERULONEPHRITIS IN ADULTS. 1873 27

Focal segmental glomerulosclerosis (FSGS) recently has been recognized as a common cause of proteinuria in dogs in general, and in Miniature Schnauzer dogs in particular. This study describes the morphologic features present in the kidneys of 8 related proteinuric Miniature Schnauzer dogs. The FSGS, characterized by solidification of portions of the capillary tuft, affected 32% to 49% of examined glomeruli in these dogs. Synechiae, often accompanied by hyalinosis, were present in 13% to 54% of glomeruli and were more prevalent in older dogs. Seven of 8 dogs had arteriolar hyalinosis. Ultrastructurally, all dogs had evidence of a podocytopathy in the absence of electron-dense deposits, glomerular basement membrane splitting, or fibrils. All dogs had multifocal to extensive podocyte foot process effacement. Other podocyte changes included microvillous transformation, the presence of vacuoles or protein resorption droplets, cytoplasmic electron-dense aggregates, and occasional binucleation. Variable amounts of intraglomerular lipid were present in all dogs. All dogs were proteinuric, with measured values for the urine protein-to-creatinine ratio ranging from 1.2 to 6.5. Azotemia was mild to absent and dogs were euthanatized at 5.1 to 14 years of age, in all cases due to nonrenal diseases. The underlying cause of FSGS in these Miniature Schnauzer dogs has yet to be determined, but contributors likely include genetic podocytopathy, lipid abnormalities, and glomerular hypertension.
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PMID:Focal Segmental Glomerulosclerosis in Related Miniature Schnauzer Dogs. 2919 Nov 33


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