Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors summarize their observations of 18 children with orthostatic proteinuria. The average time of follow-up was 4 and half years. They examined body measures and renal functions of the patients and compared their blood pressure, pulse rate, electrocardiographic curve, morphological and positional conditions of kidneys in lying and standing position, as well as change of quantity and quality of proteinuria (high, middle and low molecular weight) at day time and night both in proteinuric children with and without ptosis renis and in controls. The patients were taller than the average, but their body mass was small compared to their weight. Ptosis renis was found in 11 patients. Renal functions remained good. The authors detected changes only in quantity and quality of proteinuria during of long term follow-up, the other parameters remained normal or the change was like that of the controls. They propose, that these two parameters are of prognostic importance.
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PMID:[Long-term follow up of children with orthostatic proteinuria]. 237 63

The value of the urinary dipstick in the assessment of proteinuria was investigated in a study correlating laboratory measurements of protein and albumin against the dipstick protein in the same samples of urine; 94 patients (100 admissions) were studied at the Royal Air Force Renal Unit, each patient collecting two 24-h urine samples. Along with each 24-h sample, 10-ml aliquots of urine were obtained at 3 designated times during the day for both ward dipstick testing and laboratory assay; + or more on the dipstick correlated with abnormal proteinuria (greater than or equal to 150 mg/24 h) in 88% of cases, whilst trace values straddled the level of significant proteinuria. Further differentiation of trace was possible by repeat testing during the day. The subsequent presence of a dipstick negative during that day correlated with normality in all but 5% of cases. In order to ensure detection of renal disease presenting as isolated orthostatic proteinuria, assay of the mid-morning sample is recommended.
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PMID:Proteinuria--what value is the dipstick? 270 9

The authors discuss the correlations between the upper calyx syndrome and proteinuria. The syndrome was demonstrated in 33.6 per cent of all children with orthostatic proteinuria hospitalized at the Paediatric Clinic, Martin (Czechoslovakia) during 1978-1985. They consider the possible relations between these conditions that could be mediated by the activation of the renin/angiotensin II system. The direct stimulus of this system could rest in local ischaemization of parenchyma in the region of the proximal pole of the kidney or its partial passive congestion. They assume that these changes become more marked in the standing position and may cause proteinuria of orthostatic character. The inhibition of the renin/angiotensin II system may obviously lead to decreased proteinuria.
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PMID:Contribution to the aetiopathogenesis of orthostatic proteinuria in children: relation to the upper calyx syndrome. 274 92

Proteinuria may be an indication of underlying disease or may be found in various physiologic states. Careful quantitation of urinary protein and thorough patient evaluation are necessary to determine if proteinuria is cause for concern. Transient and orthostatic proteinuria appear to be benign, but persistent proteinuria may be a manifestation of serious disease.
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PMID:Asymptomatic proteinuria. Benign disorder or harbinger of disease? 337 58

A distinct glomerular damage characterized by the following clinical and pathological findings was verified in 20 children with a proteinuria. The clinical features were: 1) glomerular damage was frequent in adolescent males, the male to female ratio being 3:1; 2) the onset was initiated by asymptomatic proteinuria which remitted spontaneously after 3-5 years, with no resulting nephrotic syndrome; 3) there was no apparent cause for the proteinuria such as postural proteinuria, wandering kidney, hypertension or heart disease; 4) in no patient was there a past history of infection or occurrence of other diseases; 5) there were no morphological alterations except for fusion of the epithelial foot processes in about 40% of the glomerular capillary wall; and 6) immunofluorescence microscopy revealed the lack of deposition of immunoglobulins in 20 patients and deposits of complement (C3) or fibrinogen in 4 out of 20. The degree of fusion of epithelial foot processes in incomplete foot process disease was significantly different from that seen in orthostatic proteinuria, thin basement membrane syndrome and minimal change nephrotic syndrome. Compared to the latter, incomplete foot process disease is likely to occur at a higher age with a peak at adolescence, then remit spontaneously without therapy. These events may constitute a distinct entity.
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PMID:Benign persistent asymptomatic proteinuria with incomplete foot process disease in adolescents: a new clinical entity? 369 Aug 98

Urine samples from 110 patients with different proteinuric diseases in childhood were analysed by Cellulose Acetate Electrophoresis (CAE) and several samples were also analysed by Sodium Dodecyl Sulphate Polyacrylamide Gel Electrophoresis (SDS-PAGE). CAE allowed the classification of proteinurias into 4 patterns; Tubular, Glomerular I, Glomerular II and Glomerular III, by albumin/globulin ratio, value of % gamma globulin fraction (% gamma) and alpha 1/alpha 2 globulin ratio. Proteinurias of the Tubular pattern included various diseases with tubular proteinuria, while proteinurias of the Glomerular I, II and III patterns included mainly postural proteinuria, proteinuria of nephrotic syndrome and proteinuria of various nephropathies, respectively. SDS-PAGE confirmed the tubular and the glomerular origins of the proteins. In the present study we described the clinical usefulness of CAE in the screening of proteinuric children for the following reasons. This method could be performed easily and immediately. This is one of the necessities for mass screening of proteinuric children. CAE can be helpful as one of indications of renal biopsy, since patients with the Glomerular III pattern often showed glomerular alterations and should be diagnosed histologically. Good correlation between % gamma and clinical data was found in follow-up study, so CAE is also helpful in understanding the disease course. Thus. CAE is recommended as a routine screening method of proteinuria as well as SDS-PAGE.
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PMID:Clinical usefulness of cellulose acetate electrophoresis as a screening of proteinuria in childhood. 403 Feb 20

An adolescent, contemplating a military career, was found to have orthostatic proteinuria. A thorough evaluation failed to reveal any renal abnormalities. He was tested on a milk-free diet at the request of the parents. The proteinuria cleared, but recurred on an initial open challenge; it did not recur subsequently on a blinded challenge. This experience suggests that patients with orthostatic proteinuria should be evaluated with an elimination diet trial.
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PMID:Orthostatic proteinuria and milk ingestion. 404 80

One thousand, eight hundred and forty-six apparently healthy nursery and school children living in the Khartoum area and belonging to different socio-economic classes were studied. Nine hundred and thirty-seven were boys, 909 girls. Their ages ranged from three to 16 years. N-multistix strips were used to test for proteinuria and haematuria, the former being also checked by the sulphosalicylic acid test. Children with proteinuria of 1+ or more were further investigated by examining their urinary sediment for abnormal deposits and by testing for orthostatic proteinuria using day and night specimens of urine with specific gravity of 1.018 or more. Children who had no proteins on orthostatic testing were rescreened for proteinuria 10-14 days after the initial screening. The prevalence rate for proteinuria was 7.2% with no significant difference between boys and girls. In both sexes the prevalence rate increased significantly with age but was not influenced by the socio-economic status. Of the children with proteinuria, haematuria occurred in 27% and abnormal urinary deposits in 14.8%. Orthostatic testing showed a negative result for proteins in 44%, orthostatic proteinuria in 40%, of whom a third had either abnormal urinary sediments or haematuria, and continuous proteinuria in 15.6% of whom the majority had abnormal deposits.
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PMID:Proteinuria in Sudanese children. 608 53

Twenty-one protein components were measured in urine specimens from 12 subjects with postural proteinuria in the recumbent posture and after a period of upright lordotic posture. The lordotic posture produced an increased urinary excretion of total protein and 19 protein components, particularly of albumin, IgG globulin, and transferrin (128, 68, and 167-fold, respectively). However, 90 min after the lordotic posture, most of the protein components returned to initial values, whereas albumin, IgG globulin, and transferrin remained high. beta 2-Microglobulin, retinol binding protein, and lysozyme showed the smallest increases after the lordotic posture. These findings suggest that proteinuria occurring after the lordotic posture may be characterized by an increased glomerular permeability.
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PMID:Quantitative determination of urinary protein components of children with postural proteinuria. 635 21

Percutaneous renal biopsy was performed on 15 patients with orthostatic proteinuria and 6 control subjects without proteinuria in order to investigate possible renal alterations. The light-microscopic findings were either normal or showed slight mesangial proliferation in the orthostatic group but were normal in the control subjects, while the immunofluorescence-microscopic study revealed mesangial, capillary or arteriolar deposits of complement C3 and/or immunoglobulins in 10 out of 12 cases with orthostatic proteinuria; complement C3 was seen in only one control subject. The electron-microscopic findings were similar in the two groups, showing slight subepithelial, intramembranous and mesangial alterations. Focal loss of the epithelial foot processes was seen in only one case with orthostatic proteinuria. It is concluded that there are no histological, electron microscopical or immunohistochemical alterations specific for orthostatic proteinuria. A finding of complement in the glomeruli in about half and of immunoglobulin in some of the patients with orthostatic proteinuria is in favour of an association to present or previous glomerulonephritis.
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PMID:Renal biopsy findings in orthostatic proteinuria. 708 Aug 9


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