Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 54-year-old schizophrenic patient who presented with hyponatremia and nephrotic-range proteinuria was subsequently discovered to have a gastric adenocarcinoma. Psychogenic water drinking, sodium depletion, and cardiac, adrenal, hepatic, and thyroid disease were excluded as causes of hyponatremia. The serum creatinine concentration was normal, and, although renal biopsy showed changes consistent with immune complex glomerulopathy, proteinuria remitted without treatment. Moderately severe hyponatremia persisted, and the diagnosis of gastric adenocarcinoma was made after the onset of early satiety 1 year later. Surgical exploration at the time of partial gastric resection revealed local metastatic lymph node involvement. Following the patient's uneventful recovery from surgery, studies of osmoregulation of vasopressin release and renal water handling were performed to determine the cause of chronic hyponatremia refractory to sodium chloride administration. Oral water loading studies revealed normal urinary diluting ability and appropriate suppression of plasma vasopressin concentrations. However, hypertonic sodium chloride infusion studies revealed a highly significant correlation between plasma osmolality and plasma vasopressin concentration, and a low osmotic threshold for vasopressin release based on linear regression analysis of the plasma vasopressin response to increasing plasma osmolality. Low osmotic threshold for vasopressin release was confirmed by exponential (log linear) and parabolic methods of data analysis. The findings in these studies are consistent with the typical features of the reset osmostat variant of the syndrome of inappropriate antidiuresis. To our knowledge, this is the first report of the occurrence of this syndrome in association with gastric adenocarcinoma.
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PMID:Chronic hyponatremia due to resetting of the osmostat in a patient with gastric carcinoma. 836 36

1. Tamm-Horsfall glycoprotein was determined, by radioimmunoassay, in samples of urine from normal individuals under a variety of physiological conditions. 2. The amount of glycoprotein excreted in 24 h by our population (39 +/- 13 mg, corrected for body surface area) was found not to be influenced by sex, age (19-60 years) or amounts of Ca2+, Mg2+ and Na+ excreted. 3. Urine samples collected at 2 h intervals over 24 h from individuals drinking in response to thirst, contained quantities of the glycoprotein which showed high positive correlations with urine volumes, but not with Ca2+, Mg2+ or Na+ excretion. 4. The amounts of urine and of the glycoprotein were correlated for individuals in antidiuresis, induced by restriction of water intake. Relatively small amounts of glycoprotein were excreted by individuals in states of water-induced diuresis. 5. The amounts of glycoprotein excreted after exercise were positively correlated with the small volumes of urine voided, but they were uninfluenced by the degree of proteinuria or of hyaline cast formation. 6. The half-life for turnover of the glycoprotein in a given individual is highly variable, from a minimum of 3-7 to a maximum of 168 h.
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PMID:Factors affecting excretion of human urinary Tamm-Horsfall glycoprotein. 719 48