Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

213 patients with urinary schistosomiasis were investigated under field conditions in the Peoples Republic of Congo by quantitative parasitological examination, urine analysis and abdominal ultrasonography. The study group consisted mainly of children. Disease related pathological ultrasonographical findings were dependent on the intensity of infection. Sixty patients had bladder wall thickening and 55 patients had vesical polyps. Those with multiple vesical polyps were the only patients with urinary retention and they had a significantly higher proteinuria than those with a singular polyp. Obstructive uropathy of different degrees was encountered in 50 cases. Of these, 21 patients had moderate to severe urinary tract obstruction and in all cases except one also presented concomitant vesical abnormalities. Nine patients revealed bilateral obstructive uropathy. Lesions of the lower urinary tract were a predisposing factor in the development of urinary tract obstruction. Morbidity of study patients was considered to be substantial. A proteinuria of more than one gramme per litre in spontaneously voided midday urine indicated a high probability for the presence of urinary tract obstruction and was considered an urgent indication for antischistosomal treatment.
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PMID:Morbidity in urinary schistosomiasis: relation between sonographical lesions and pathological urine findings. 393 56

The histories of 22 infants presenting during the first year of life with obstructive uropathy due to posterior urethral valves were analyzed to determine outcome and prognostic features. Mean patient age at the time of the initial surgical intervention was 39 days, and the mean duration of followup inclusive of renal function data was 5.8 years. One patient died (5 per cent) and one had end stage renal disease. The mean preoperative and postoperative serum creatinine concentrations during the initial hospitalization were 3.1 and 1.4 mg. per dl., respectively. Neither value was significantly predictive of the creatinine concentration at final followup. In contrast, the nadir creatinine value during the first year of life correlated significantly with final renal function. Children with nadir creatinine values less than or equal to 0.8 mg. per dl. by 12 months of age maintained creatinine levels less than or equal to 1.1 mg. per dl. at the time of final evaluation, whereas children with higher values during the first year of life were likely to have progressive renal failure. Of 19 final creatinine determinations 6 were normal and 5 exceeded 1.5 mg. per dl. Proteinuria, hypertension, renal biopsy findings, urinary infection, unilateral nephrectomy and type of surgery did not correlate significantly with functional outcome. Followup studies of longer duration are needed to determine the ultimate outcome of these patients, more than half of whom had some degree of renal insufficiency at final evaluation.
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PMID:Prognostic features in infants with obstructive uropathy due to posterior urethral valves. 396 41

Chronic pyelonephritis is secondary to urinary tract infection associated with vesico-ureteric reflux or obstructive uropathy. Pyelonephritis scarring almost always occurs in early childhood and is linked to the concomitant presence of urinary tract infection and renal papillae allowing intrarenal reflux. When bilateral, pyelonephritis scarring may lead to end-stage renal disease. Destruction of the renal parenchyma occurs over years and is often accompanied by arterial hypertension and proteinuria. Surgical correction of vesico-ureteric reflux does not prevent further renal scarring. Since sterile reflux does not appear to be harmful, it is important to diagnose vesico-ureteric reflux early and prevent urinary tract infection by administering chemoprophylaxis during the first seven years of life.
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PMID:[Importance of vesico-ureteral reflux in the pathogenesis of chronic pyelonephritis]. 634 Jan 86

It has been postulated that in some patients with obstructive and reflux uropathy proteinuria develops through an intermediate mechanism of immune complex glomerulonephritis involving antigenic material of renal tubular epithelium. A patient with a unilateral ureterocele and nephrotic syndrome underwent bilateral renal biopsies during surgical correction of the obstruction. The obstructed kidney showed mild pyelonephritis, but both kidneys showed a glomerulopathy with electron-dense deposits in the mesangial and paramesangial regions associated with positive immunofluorescence for immunoglobulin M (IgM) and the third component of complement (C3). An IgM antibody was eluted from the biopsy specimens and it reacted by indirect immunofluorescence with normal renal tubular epithelium and with the patient's renal tubular epithelium. The eluate also reacted with pre-eluted glomeruli of the patient, but not with normal glomeruli. All antibody activity could be removed from the eluate by pre-incubation with normal kidney. It is concluded that the unilateral renal obstruction produced tubular injury so that as yet unidentified antigens were recognized by the immune system. The resultant antibody response gave rise to circulating immune complexes which were then deposited in glomeruli with subsequent glomerular damage and nephrotic syndrome.
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PMID:Demonstration of an antibody to tubular epithelium in glomerulonephritis associated with obstructive uropathy. 700 83

Hematuria and proteinuria have been noted in athletes after heavy exercise. Evaluation of 383 marathoners after a 26-mile, 385-yard run revealed hematuria in 17 per cent and proteinuria in 30 per cent. These abnormalities were not related to sex. The condition is transient and appears to be benign. A diagnostic approach to avoid missing significant renal or urologic disease is outlined.
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PMID:Stress hematuria: athletic pseudonephritis in marathoners. 705 10

The present study was designed to evaluate the urinary albumin excretion in 62 patients with essential hypertension. None of them had prior proteinuria or history of nephropathy or uropathy. Patient data, blood pressure, proteinuria using Bradford's method, albuminuria by radial immunodiffusion, urinary SDS-PAA electrophoresis, plasma glucose, serum creatinine, serum cholesterol were determined. The urinary albumin excretion was significantly higher (p < 0.001) in the group of hypertensive patients (19.22 +/- 2.36 micrograms/min) compared to a group of 20 control subjects (4.17 +/- 0.67 microgram/min). Compared to a subgroup of hypertensive patients without ischemic heart disease (12.07 +/- 1.30 micrograms/min) microalbuminuria was higher (43.74 +/- +/- 5.74 micrograms/min; p < 0.001) in a subgroup of 14 patients with essential hypertension and ischemic heart disease with severe coronary events: unstable angina pectoris (9 patients), myocardial reinfarction (2 patients), ventricular arrhythmias (3 patients). A positive correlation between the microalbuminuria and the duration of hypertension was found (r = 0.64; p < 0.001). Therefore, microalbuminuria may represent a marker of the severity of vascular involvement in hypertensive patients.
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PMID:Microalbuminuria in hypertensive patients. 808 6

In 103 subjects with asymptomatic isolated haematuria (persisting for more than 6 months in the absence of proteinuria, bacteriuria, impaired haemocoagulation or urological disease) renal biopsy was performed. The mean age of the patients was 25.2 years, range 14-58 years. In 94% glomerular changes were detected--most frequently minimal glomerular lesions (67%) and proliferative mesangial glomerulonephritis (15%). Focal segmental proliferative glomerulonephritis was rare (4%). Immunofluorescent examination revealed IgA nephropathy in 40% (all cases of diffuse and focally segmental proliferative glomerulonephritis and one quarter of minimal glomerular lesions). Changes of tubules and interstitium were recorded in 26%, with the exception of one patient they were always associated with glomerular affection. From the investigation ensues that the predominating cause of isolated asymptomatic haematuria, not clarified by non-invasive examination, is usually not serious and is an affection frequently associated with tubulointerstitial changes. As many as 40% of isolated cases of haematuria may be the manifestation of IgA nephropathy. The deposition of IgA is more frequently associated with a more advanced grade of glomerular affection. Indication of diagnostic renal biopsy in isolated haematuria remains individual.
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PMID:[Isolated hematuria in adolescents and adults. The value of renal biopsy]. 851 37

A group od 129 patients with persistent asymptomatic microhematuria was studied for 7 years (1987-1994). At the beginning of the study, 31 patients showed mild proteinuria (less than 1 g/day) and in the rest of 98 patients, 21 showed microalbuminuria. At the end of the study none of the patients developed renal failure, urological disease, hypertension. Six patients out of 31 with mild proteinuria (less than 1 g/day), developed an increase of proteinuria over 2 and 3/day and underwent a renal biopsy while 2 out of 21 patients with altered microalbuminuria completely recovered after the follow-up period. The rest of 77 patients at the end of the study still showed isolated microhematuria. The results of this study support the hypothesis that in a population with age range between 16 and 28 years, the presence of persistent microhematuria, also associated with mild proteinuria, even for a long time, does not seem to lead to changes of renal function or to urological diseases.
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PMID:[7-year-follow up (1987-1994) of a population with asymptomatic persistent microhematuria and normal renal function]. 904 3

Efficiency of urine sediment analysis was evaluated in 423 specimens including 86 documented renal disorder ones using three methods; a traditional centrifugal and microscopic one, an image-scanning one and a flow cytometric one. Among the three methods, good correlations were observed in white blood cells and epithelial cells. Between white blood cells and bacterial counts a good correlation was observed only in the flow cytometry one. Female specimens usually demonstrated high values in white blood cells except with the microscopic method. Casts in patients with renal disorder exhibited significantly high in the flow cytometric method. In all methods, proteinuria specimens showed high cast count in the sediment. From these results we concluded that the flow cytometric method was clinically useful, especially in urinary tract disorder specimens.
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PMID:Comparison of three methods for analysis of urinary sediments. 904 47

Risk factors, prevalence, and intensity of infection with Schistosoma sp. and prevalence and magnitude of morbidity caused by schistosomiasis was assessed in a stratified random sample of 16,433 subjects from 2,409 households in 33 rural communities in Minya Governorate, Egypt. The prevalence of S. haematobium ranged from 1.9% to 32.7% among the communities and averaged 8.9%. The average intensity of infection was a geometric mean egg count (GMEC) of 8.5 per 10 ml of urine and ranged from 1.6 to 30.9. Prevalence was maximum (18-20%) in those 10-20 years of age and higher in males than in females. Intensity of infection followed the same pattern. Infection with S. mansoni was present almost exclusively in a single village, confirming spread of this species up the Nile River and its focality in Minya. Risk factors for S. haematobium infection were an age from 11 to 20; male gender; males bathing in, women washing clothing or utensils in, and children swimming or playing in canals; and a history of, or treatment for, schistosomiasis. Recent history of burning micturition was associated with infection in children but not in adults, while a history of blood in urine correlated with S. haematobium infection in both age groups. Reagent strip-detected hematuria and proteinuria were highly associated, particularly in children, with S. haematobium infection. The presence of hepatomegaly or splenomegaly on physical examination was not associated with S. haematobium ova in the urine. Hepatomegaly, as measured by ultrasonography in the midclavicular line or the midsternal line, or ultrasonography-detected splenomegaly were not present more frequently in infected subjects than in uninfected subjects. Schistosoma ova were not detected more frequently in urine of subjects with ultrasonography-detected periportal fibrosis than in the urine from subjects without this finding. Ultrasonography-detected urinary bladder wall lesions were detected in only 6 (0.3%) subjects and obstructive uropathy was observed in 54 (2.7%) subjects. The absence of an association between prevalence of urinary tract morbidity and S. haematobium infections was surprising. Two possible explanations are 1) that repeated chemotherapy has reduced the prevalence of urinary tract morbidity and 2) that morbidity was not being detected by the ultrasonographic operators.
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PMID:The epidemiology of schistosomiasis in Egypt: Minya Governorate. 1081 2


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