Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Human infection with Schistosome hematobium is common in the Subsahel region of Ghana. Between January 1987 and July 1988, a study was conducted of all pregnant women attending Bawku District Hospital Antenatal-Clinic (ANC), Bawku/Upper East Region (Subsahel-Savanna), Ghana, with complaints and S. hematobium detected in their urine. Pregnant women received iron and folic acid tablets and tetanus-immunization. The partograms of 500 consecutive deliveries in Bawku Hospital (1600 deliveries/year) in the same period were used to collect data for the control group. To estimate the prevalence of S. hematobium infection in pregnancy in Bawku District, 200 pregnant women with a healthy pregnancy were screened. In 9 cases (4.5%) S. hematobium eggs were found in the urine. In 197 cases, the urine test revealed that 51 had proteinuria, 38 had blood in the urine, and 19 women had proteinuria and hematuria. The values were 22-40% with an average of 30%. The hospital delivery analysis of 500 consecutive partograms of the control group showed an average gestation at delivery of 38 weeks, birth weight of 2.917 kg, birth length of 48 cm, and gravidity of 3.6. 41 pregnant women were infected with S. hematobium. One of them had a double-infection of S. hematobium an S. mansoni. Because of 18 drop-outs, the outcome of the pregnancy in 23 women was followed up to delivery. Preterm (37 weeks) deliveries were 34.8% in this group vs. 23.8% in the control group. The births weights in term deliveries (37 weeks) were not significantly different (3012 g vs. 3103 g). In the preterm deliveries, the birth weight was significantly lower in the infected group (1768 g vs. 2457 g, p0.005). The complaints leading to subsequent diagnosis of infection were in 28 cases dysuria, 17 hematuria, 8 waistpain, and 10 lower abdominal pain. In the hospital deliveries, there was one neonatal death in which case the diagnosis of S. hematobium infection was made at the time of the premature delivery.
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PMID:Schistosoma haematobium infection in pregnancy. 135 2

The risk of renal damage from diphtheria, tetanus and typho-paratyphoid vaccination was assessed by means of a prospective and a retrospective study. The prospective study involved 817 young adults without history nor signs of urinary disease and therefore, with presumably healthy kidneys. Urine samples were taken before and after each injection and examined for proteinuria and microscopic haematuria. After a total of 1712 doses there was no evidence of post-vaccination nephropathy. In a retrospective study of 63 patients with various forms of glomerulonephritis vaccination was found to be responsible for one case of acute renal failure consecutive to proliferative lesions and one case of syndromic reaction in an asymptomatic Berger's disease. These two complementary studies show that post-vaccination nephropathy may occur, albeit rarely, and that current preventive measures should be pursued.
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PMID:[Renal risk of vaccinations. Prospective survey and retrospective study]. 622 1

Recently, the induction of SLE in naive mice employing monoclonal anti-DNA antibodies (anti-DNA Ab) carrying the pathogenic idiotype 16/6 (16/6 Id) has been reported. In the current study we report on the induction of experimental SLE by polyclonal IgG anti-DNA Ab derived from a patient with active SLE and carrying the 16/6 Id. Two different experiments were conducted in which BALB/c mice were immunized in the footpads with 1 microgram/ml or 5 micrograms/ml of anti-DNA Ab. The first experiment showed the appearance in the immunized mice of high titre anti-DNA Ab together with antinuclear antibodies, alopecia and proteinuria. In the second experiment we compared, as immunizing agents, 16/6 positive anti-DNA Ab and 16/6 negative anti-tetanus toxoid antibodies (anti-TT Ab) obtained from the serum of the same patients. Our results show that only mice immunized with 16/6 positive antibodies produced anti-DNA Ab, while mice immunized with anti-TT Ab did not show any DNA-binding activity but, surprisingly, developed high titre anti-cardiolipin antibodies.
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PMID:Induction of experimental SLE in naive mice by immunization with human polyclonal anti-DNA antibody carrying the 16/6 idiotype. 768 55

To study the frequency and examine the role of rhabdomyolysis in the acute renal failure in tetanus 18 patients with the diagnosis of generalized tetanus consecutively admitted to the infectious disease hospital were evaluated. Of these 14 were male and 4 female with mean age of 31.8 +/- 2.0 years. Except for mild proteinuria recorded in 9 patients, the urinalysis were unremarkable. Serum creatinine higher than 1.4mg/dl was recorded in 39% of the patients, abnormal levels of CPK in 87,5% and serum myoglobin greater than 120 micrograms/l in 39% of the patients. Oliguria was documented in one patient and none required dialysis therapy. No correlation was found between renal failure and myoglobin and/or CPK serum levels. Acute renal failure in tetanus was not infrequent; usually it was non-oliguric, mild and transient and not related to the severity of the disease or to serum levels of myoglobin and/or CPK.
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PMID:Tetanus as a cause of acute renal failure: possible role of rhabdomyolysis. 811 81

A peptide based on the complementarity determining region (CDR)1 of a human monoclonal anti-DNA autoantibody (hCDR1) was shown to either prevent or treat an already established murine lupus in systemic lupus erythematosus (SLE)-prone mice or in mice with induced experimental SLE. The present study was undertaken to determine the therapeutic potential of hCDR1 in a model of lupus in severe combined immunodeficient (SCID) mice engrafted with peripheral blood lymphocytes (PBL) of patients with SLE. To this end, PBL obtained from lupus patients were injected intraperitoneally into two equal groups of SCID mice that were treated either with the hCDR1 (50 micro g/mouse) once a week for 8 weeks, or with a control peptide. Mice were tested for human IgG levels, anti-dsDNA autoantibodies, anti-tetanus toxoid antibodies and proteinuria. At sacrifice, the kidneys of the successfully engrafted mice were assessed for human IgG and murine complement C3 deposits. Of the 58 mice transplanted with PBL of SLE patients, 38 (66%) were engrafted successfully. The mice that were treated with the control peptide developed human dsDNA-specific antibodies. Treatment with hCDR1 down-regulated the latter significantly. No significant effect of the treatment on the levels of anti-tetanus toxoid antibodies could be observed. Treatment with hCDR1 resulted in a significant amelioration of the clinical features manifested by proteinuria, human IgG complex deposits as well as deposits of murine complement C3. Thus, the hCDR1 peptide is a potential candidate for a novel specific treatment of SLE patients.
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PMID:Amelioration of lupus manifestations by a peptide based on the complementarity determining region 1 of an autoantibody in severe combined immunodeficient (SCID) mice engrafted with peripheral blood lymphocytes of systemic lupus erythematosus (SLE) patients. 1532 Sep

The CD40-CD154 costimulatory pathway has been shown to be critical for both T- and B-cell activation in autoimmune disease. Here, we assessed the effects of blocking this pathway using CD40 DNA vaccine enhanced by dendritic cell targeting on the development of active Heymann nephritis, a rat model of human membranous nephropathy. DNA vaccination delivers plasmid DNA encoding the target antigen, either alone or in combination with enhancing elements, to induce both humoral and cellular immune responses. To determine whether CD40 DNA vaccine targeting the encoded CD40 directly to dendritic cells would improve the efficacy of the vaccination against self-protein CD40, we utilized a plasmid encoding a single-chain Fv antibody specific for the dendritic cell-restricted antigen-uptake receptor DEC205 (scDEC), the target gene CD40, and the adjuvant tetanus sequence p30. This vaccine plasmid was compared to a control plasmid without scDEC. Rats vaccinated with scDEC-CD40 had significantly less proteinuria and renal injury than did rats receiving scControl-CD40 and were protected from developing Heymann nephritis. Thus, CD40 DNA vaccination targeted to dendritic cells limits the development of Heymann nephritis.
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PMID:DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats. 2322 73