Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twelve kidney, five biopsy and seven necropsy specimens, all from schistosomiasis mansoni patients were studied by light and immunoflurescent microscopy in an attempt to detect antigen in the glomerular walls. Deposits of IgM, IgG,I gA, IgE, complement C3 and fibrinogen were observered in most cases. Antigen was successfully detected in two cases(one biopsy and one necropsy specimen), both exhibiting proliferative glomerulonephritis. The only clinical manifestation was a slight proteinuria. IgG antibodies eluted from the sutopsy kidney homogenates showed specific binding mostly to Schistosoma mansoni gut, thus spggesting that the fixed antibodies (eluates) are, at least partially, consituted by antibodies similar to the anti-circulating antigen. These data reinfroce the hypothesis that renal injury in schistosomiasis is mediated through an immune complex disease.
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PMID:Human schistosomiasis: Schistosoma mansoni antigen detection in renal glomeruli. 6 11

In a patient with chronic hepatosplenic schistosomiasis a segmental sclerosing nephropathy led to terminal renal failure. The demonstration of glomerular capillary deposition of immunoglobulin and complement with electron dense deposits and lucent deformities of the glomerular basement membrane and the presence of antischistosome adult worm antibody in serum suggested that this was an example of immune complex nephropathy. Successful renal transplantation followed by niridazole treatment of the schistosomiasis induced a transient relapse of renal dysfunction with proteinuria and a fall in serum complement. The pathogenic schistosomal adult worm antigen was identified by immunofluorescence in the mesangium of the transplant; complement and immunoglobulin were present also in that site.
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PMID:Immune complex nephropathy i schistosomiasis. 12 58

A retrospective study of 60 renal biopsies obtained from nephrotic subjects with schistosomiasis showed amyloid deposits in 10 cases. Distribution was usually segmental, mainly mesangial and overlapped with the conventional mesangio-proliferative lesions of schistosomiasis. The invariable clinical presentation was proteinuria with generalized oedema of insidious onset and a slowly progressive or intermittent course. Differences from conventional schistosomal nephropathy are described. Response to anti-schistosomal treatment was very poor. Repeat renal biopsies showed no regression of the lesions. The possible links between schistosomiasis and amyloidosis are discussed and causes of amyloid deposition suggested.
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PMID:Renal amyloidosis and schistosomiasis. 55 61

Using the Raji cell radioimmune assay, we found low levels of circulating immune complexes (IC) in a small percentage of patients with schistosomiasis and filariasis. C3d levels, measured by immunoprecipitation, were elevated in a large number of these patients, whereas complement levels were within normal limits. Proteinuria was not found in any of the 55 patients studied. Circulating IC or elevated C3d levels were not found in any of the 19 patients with hydatidosis. The increased C3d levels, apparently not related to circulating IC, may be due to direct complement activation by parasite antigens or to sequestered IC. The latter hypothesis appears more attractive because the highest levels of C3d were found in schistosomiasis whereas schistosome antigens were unable to activate complement in vitro.
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PMID:Circulating immune complexes and C3d in human parasitosis. 57 77

In order to investigate the prevalence and type of glomerular lesions in patients with overt Schistosoma haematobium (S H) infection, renal biopsies obtained from 13 patients were studied by light microscopy (in 13), ultra-structural (in 9) and immunofluorescence (in 11) techniques. Renal function was normal in all patients, only two had mild proteinuria. Glomerular deposits were absent in four patients. Electron microscopy showed in four cases an increase of the mesangial matrix with subendothelial deposits in the mesangial area. Subepithelial deposits were also present in one of these cases. Associated or isolated deposits of IgM, IgG, Clq, C3 were identified in the glomeruli of seven patients. Attempt to detect schistosomal antigen by using a high titer human anti-SH conjugate serum was unsuccessful. The relation between the glomerular lesions observed and schistosomiasis and other parasitic diseases is discussed.
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PMID:Glomerular lesions in patients with Schistosoma haematobium infection. 72 31

A clinical epidemiological study was conducted to determine the association, if any, between the incidence of urinary schistosomiasis and urinary tract infection. The urinary excretion of protein and cells was also studied. Data was collected from 2 rural Nigerian communities--1 with a low level of endemic urinary schistosomiasis and the other with a high level. Midstream urine specimens were collected from the 2 populations. The laboratory procedures are described and the findings are presented in detailed tables. Proteinuria, haematuria, pyuria and bacteriuria were found to occur at significantly higher levels in the area of high than low schistosomiasis endemicity.
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PMID:Studies on the prevalence of renal disease and hypertension in relation to schistosomiasis. III. Proteinuria, haematuria, pyuria and bacteriuria in the rural community of Nigeria. 75 49

Radiologic findings are reported from 2 communities, 1 with high and the other with low endemicity of urinary schistosomiasis, of Ibadan. After studying the 2 rural communities with varying endemicities of urinary schistosomiasis by total cross-sectional population survey, a stratified sample was obtained using defined criteria (all cases of proteinuria of 100 mg%; all cases of diastolic blood pressure of 90 mm or greater; all cases with significant bacteriuria; 20% of cases with history of nocturia; and age-selected trace and absent proteinuria for 20% of cases). Plain X-ray abdomen and intravenous pyelogram were carried out on this defined sample population. Findings on plain abdominal X-ray, using the usual parameters of psoas and kidney shadows in the Nigerian, indicated that the 2 communities studied were similar, but urinary calculi and urinary tract distortion were significantly more prominent in the community with the higher endemicity of urinary schistosomiasis. X-rays are not included in the text, instead tabular information on the morphology of renal areas is presented.
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PMID:Studies on the prevalence of renal disease and hypertension in relation to schistosomiasis. V. Radiological findings: plain X-ray abdomen and intravenous pyelogram. 75 50

Salmonella typhi or Paratyphi A was isolated from the blood in 16 out of 21 Suanese patients who had prolonged fever of one of 10 months' duration and hepatesplenic schistosomiasis. Most patients had severe anaemia. The serum alkaline phosphatase was raised in 16 patients. Bilharzial lesions were demonstrated in the liver biopsies of 10 patients. Three patients had in addition the nephrotic syndrome and moderate proteinuria was present in nine other patients. Changes of proliferative glomerulonephritis were noted in the renal biopsies of two patients with the nephrotic syndrome. Treatment with chloramphenicol cured the salmonella infection in all patients, reversed the raised alkaline phosphatase and the proteinuria, and led to a marked reduction in the size of the hepatosplenomegaly.
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PMID:Salmonellosis complicating schistosomiasis in the Sudan. 85 Feb 87

The association of Schistosoma mansoni infection and proteinuria was investigated by measuring quantitative urinary protein in a defined population in an endemic area in northeastern Brazil. Persons with schistosomiasis had higher mean urinary protein than those without. Two of 162 persons with schistosomiasis had clear evidence of renal disease (pathologic proteinuria, abnormal urinary sediment). These results seemed to be related neither to the intensity of S. mansoni infection as measured by fecal egg excretion nor to the presence of hepatic and splenic enlargement in schistosomiasis.
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PMID:The association of Schistosomiasis mansoni and proteinuria in an endemic area. A preliminary report. 115 97

In a prospective study of renal involvement in 100 consecutively hospitalized patients with hepatosplenic schistosomiasis mansoni, 15 exhibited persistent proteinuria of varying degree, which in 6 instances was accompanied by hypertension. Nine patients had the nephrotic syndrome. The most common glomerular lesion in this group was membrano-proliferative glomerulonephritis. Surgical biospy obtained during splenectomy in 15 patients without clinical evidence of renal involvement showed glomerular lesions in 6 instances. Focal proliferative glomerulonephritis was the most common lesion in this group. The detection of silent glomerular lesions in patients with Schistosoma mansoni infection suggests that the glomerular alterations may precede clinical manifestations of renal disease.
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PMID:Renal involvement in patients with hepatosplenic Schistosomiasis mansoni. 125 74


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