Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 7 years (1981-1988) at the Kenyatta National Hospital (KNH), Nairobi the diagnosis of systemic lupus erythematosus (SLE) was made in 67 patients. In 23 of these patients lupus nephritis complicated the SLE. Lupus nephritis was diagnosed through renal biopsy, haematuria and proteinuria in urine with positive lupus erythematosus (LE) cell phenomenon. The histology found in these patients included 5 patients with minimal lesion, 7 patients with membranous, 3 with focal, 4 with diffuse, 3 with crescenteric and one with membranoproliferative glomerulonephritis. While patients with minimal, membranous and focal nephritis had general good outlook on low dose maintenance or intermittent high dose steroid therapy the others with diffuse, crescenteric and membranoproliferative nephritis had poor prognosis. Patients with diffuse proliferative, membranoproliferative and crescenteric nephritis tended to have septicaemia, pulmonary oedema, fluid overload and chronic renal failure with poor prognosis. These patients responded poorly to oral and parenteral steroid therapy whether high or low dose.
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PMID:Management of lupus nephritis at the Kenyatta National Hospital. 227 66

Two dogs were seen at the University Veterinary Teaching Hospital, Nairobi, Kenya, both having histories of dyspnoea, progressively enlarging abdomens, anasarca, ascites, pleural and pericardial effusion, and pulmonary oedema. One of the dogs had a mild neutrophilic leucocytosis, elevated levels of alkaline phosphatase, alanine aminotransferase, lactate dehydrogenase and proteinuria. Histopathological examination of the myocardium revealed some damage to myocytes and a mononuclear cellular infiltration involving the myocardium, liver and kidneys. The two dogs had a fondness for avocado fruits and, as the presenting syndrome is identical to that seen in goats, sheep and horses poisoned by avocados, a comparison is made and the probable manifestation of this poisoning presented.
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PMID:Putative avocado toxicity in two dogs. 789 92

Four hundred and three teenage secondary school students (50.6% males) from two girls' and two boys' Nairobi City Schools, selected by stratified sampling, were screened to determine the prevalence of proteinuria, haematuria, nitrituria and hypertension. Nine students (2.2%) had significant proteinuria while 14 (3.5%) had microscopic haematuria. Two students had combined proteinuria and haematuria. There was no statistically significant difference in the prevalence of proteinuria and/or haematuria between the sexes. Other urinary abnormalities detected were leucocyturia in 14(3.5%) and nitrites in four (1%). Leucocyturia was commonner in females (p = 0.001). Cloudy urinary appearance was significantly associated with the presence of leucocyturia (p = 0.0028) and proteinuria (p = 0.0276). Neither personal history of recurrent sore throat and skin infections nor family history of hypertension, diabetes mellitus or kidney disease was significantly associated with proteinuria or haematuria. Blood pressure tended to increase with age. Mean systolic and diastolic blood pressures were significantly higher in boys than girls in the age group 15-18 years (P < 0.001). Of the 397 students whose blood pressures were measured, four (1%) were found to be hypertensive. Weight and body mass index were strong positive correlates of blood pressure. The prevalence of proteinuria, haematuria, other urinary abnormalities and hypertension ranges between 1% and 3.5% among teenage secondary school children. The majority are asymptomatic and have no significant associations. It is recommended that routine urinalysis and blood pressure measurements should be part of the school health service so as to identify asymptomatic students who require close monitoring and/or intervention.
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PMID:Proteinuria, other selected urinary abnormalities and hypertension among teenage secondary school students in Nairobi, Kenya. 948 8

Antenatal care is now universally accepted as an essential part of obstetric care and most health authorities in developing countries are trying to offer this service to their populations. This study, part of the Nairobi Birth Survey, looks into the pattern and distribution of antenatal care in the City of Nairobi, particularly to assess the quality and appropriateness of the service. 96.4% of women attended antenatal clinic at least once, the majority (74.7%) being looked after at health center level. There was an overrepresentation of young, single, primigravidae who had received little formal education in the group that received no antenatal care. The quality of care varied from clinic to clinic but on the whole there was a tendency either not to do certain important investigations or failure to obtain the results in the cases where the tests were requested. Nearly 60% of the antenatal women had height between 155 cm and 164 cm, 2.7% had positive tests for syphilis, 10.5% were anemic and 10.3% were hypertensive. The perinatal mortality rate in the group that did not have antenatal care was found to be 4.8 times greater than that in the group that received antenatal care. 1 way of facilitating detection of risk factors is by designing an appropriate record card. An example of such a card has been successfully tested in rural areas of Kenya. The quality of antenatal care can be assessed by maternal height, blood pressure, blood group, hemoglobin, serological test for syphilis and urine examination for protein and sugar. Private doctor antenatal care tended to be inferior to hospital care. Just under 20% of the women were under 20 years old while 44% were 35 and over. A comparatively larger proportion of adolescents did not receive antenatal care. Primigravida and highly parous mothers are also classified as high risk cases. Nearly 15% of the mothers were single and showed a marked tendency for lack of antenatal care and health care center utilization. Anemia existed in 10.5% of a sample of 789 women. Proteinuria was detected in only 3.6%. In about 80% of the antenatal mothers no complications were found. Perinatal mortality and morbidity rates will be reduced as a result of antenatal care.
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PMID:The Nairobi birth survey. II. Antenatal care in Nairobi. 1226 54