Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During an endemic of mumps in 1987, urinalysis was performed in 124 children with the symptoms of mumps during the acute phase of the disease, 36 children (29.0%) with microscopic hematuria and 8 children (6.4%) with proteinuria were studied. In the children with abnormal urinalysis, whose creatinine clearance was within the normal range, an urine culture for mumps virus was also performed. Nine specimens (20.4%) were positive, 8 (88.8%) of them during the first 5 days of illness. Renal biopsy, performed in a girl with persistent hematuria, revealed a mild mesangial proliferative glomerulonephritis with deposition of immunoglobulins A and M, C3, and mumps virus antigen in the glomerulus, suggesting an immune complex deposition. Electron microscopy demonstrated a moderate number of granular electron-dense deposits in the paramesangial regions. The relationship between the development of mumps and the onset of nephritis and the immunofluorescent demonstration of mumps antigen in the glomeruli suggested that the mesangial nephropathy may have developed after the mumps infection. Therefore, in our cases, the clinical course was benign.
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PMID:Mumps associated with nephritis. 225 53

Previous studies have suggested a relationship between reproductive history, pregnancy and birth factors, and the risk of neuroblastoma. We conducted a case-control telephone interview study that included a total of 504 children under the age of 19 years with newly diagnosed neuroblastoma identified by two national collaborative clinical trials groups, the Children's Cancer Group and the Pediatric Oncology Group. A total of 504 controls, matched to cases on age, were identified by random digit dialing. Conditional logistic regression was used to estimate the matched odds ratio (OR) and 95% confidence interval (CI) with adjustment for household income, and maternal race and education. In addition, case subgroups defined by age at diagnosis, tumour MYCN oncogene amplification status, and stage were evaluated. A suggestive pattern of increased risk was seen for a greater number of prior pregnancies, history of previous miscarriages and induced abortions, with nearly a twofold increase in risk for two or more prior induced abortions (OR = 1.9, 95% CI [1.0,3.7]). No association was found for the following diseases or conditions during pregnancy: hepatitis, rubella, measles, mumps, chickenpox, mononucleosis, vaccinations, morning sickness, pre-eclampsia, bleeding, proteinuria, anaemia, urinary tract infections, heart disease, kidney disease, liver disease and diabetes. A weak association was found for hypertension during pregnancy. Several labour and delivery factors were related to an increased risk, including threatened miscarriage, anaesthetic during labour (specifically epidural) and caesarean delivery. We found associations between premature delivery (<33 weeks: OR = 1.9, 95% CI [0.7,4.8]), very low birthweight (<1500 g: OR = 2.6, 95% CI [0.7,10.3]) and risk of neuroblastoma. There was no consistent pattern of increased risk found for most factors within subgroups defined by age at diagnosis, stage or MYCN status.
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PMID:Association of pregnancy history and birth characteristics with neuroblastoma: a report from the Children's Cancer Group and the Pediatric Oncology Group. 1170 80