Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of a large renal cyst of the right kidney presenting as persistent proteinuria in a child is reported. The preoperative differentiation and pathogenesis of the proteinuria are discussed.
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PMID:Simple renal cyst manifest by proteinuria in children. 91 17

Under ultrasound guidance, we treated 25 cases of renal cyst with 99% ethanol instillation to prevent the recurrence of this disease from January 1985 to June 1987. Patients' age was from 17 to 85 years old with the average age of 63 years. Twelve cases were men, and 13 cases were women. Among the 25 cases, eleven were asymptomatic and 14 showed clinical features of lumbago, microhematuria, hypertension or proteinuria. The aspirated site was the right side in 9, left side in 14 and bilateral kidneys in 2 cases. Subsequently, cyst puncture was carried out 27 times. We encountered 12 complications following puncture. These complications were derived from the puncture itself or caused by the ethanol instillation. Flank pain caused by the injection of ethanol, nausea, causalgia or a feeling of drunkenness appeared immediately after the inoculation procedure. However, no serious complications such as pneumothorax, perirenal hematoma or infection were recognized. Some complications arose in 7 cases of 9 examples (77.8%) following more than 50 ml of ethanol injection, but the complications were observed in only 5 cases of 18 examples (22.8%) following less than 50 ml of administration. Based on these findings, ethanol injection in renal cysts appears to be useful for the treatment of this disease. In case of huge cysts when more than 50 ml of ethanol, is instilled the case should be followed up carefully after the instillation procedure.
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PMID:[Renal cyst puncture under ultrasound guidance: complications of ethanol injection]. 306 4

The amount of proteinuria is a prognostic indicator in a variety of glomerular disorders. To examine the importance of urinary protein excretion in autosomal dominant polycystic kidney disease, this study determined the clinical characteristics of autosomal dominant polycystic kidney disease patients with established proteinuria and the frequency of microalbuminuria in hypertensive autosomal dominant polycystic kidney disease patients without proteinuria. In 270 autosomal dominant polycystic kidney disease patients, mean 24-h urinary protein excretion was 259 +/- 22 mg/day. Forty-eight of 270 autosomal dominant poly-cystic kidney disease patients had over proteinuria (> 300 mg/day). The patients with established proteinuria had higher mean arterial pressures, larger renal volumes, and lower creatinine clearances than did their nonproteinuric counterparts (all P < 0.0001), a greater pack year smoking history (P < 0.05), and the projection of a more aggressive course of renal disease (P < 0.05). All autosomal dominant polycystic kidney disease patients with established proteinuria were hypertensive, as compared with 67% without established proteinuria (P < 0.001). Forty-nine patients with hypertension and left ventricular hypertrophy without established proteinuria were examined for microalbuminuria; 41% demonstrated microalbuminuria. Those with microalbuminuria had higher mean arterial pressure, larger renal volumes and increased filtration fraction. Therefore, established proteinuria and microalbuminuria in autosomal dominant polycystic kidney disease patients are associated with increased mean arterial pressure and more severe renal cystic involvement.
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PMID:Overt proteinuria and microalbuminuria in autosomal dominant polycystic kidney disease. 789 1

The simple renal cyst (SRC) is a common entity even though its actual incidence is difficult to determine given that it tends to manifest itself in an asymptomatic fashion. Occasionally, cases of SRC with clinical manifestations have been described in the literature, such as arterial hypertension (AHT) and biological alterations such as hematuria or proteinuria. The purpose of this article is to find the prevalence of AHT, proteinuria, and hematuria in patients with SRC detected via echography. 1,197 echographs that explored the renal area--a number equal to that of the number of patients--were reviewed. In 66% of the cases, the echographs were taken for some purpose unrelated to renal pathology. For those who presented SRC, blood pressure, proteinuria per 24 hours, and urine sediment were determined. SRC was detected in 93 patients (7.7%). The prevalence of AHT in patients with SRC was 31%, but 57% of those were older than 85 years. Two patients presented AHT and proteinuria; both fulfilled the criteria for nephrongiosclerosis. Two other patients presented hematuria and proteinuria; one was found to be afflicted with IgA nephropathy and the other with vesical carcinoma. A patient with hematuria was a carrier of renal lithiasis. We conclude that the prevalence of AHT in patients with SRC did not yield a significantly different result from that of the general population. In those patients who presented proteinuria and/or hematuria, one cause was found to be responsible; therefore, the presence of such alterations in patients with SRC should be considered coincidental.
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PMID:[Prevalence of arterial hypertension, proteinuria and hematuria in patients with simple renal cyst]. 829 Jul 56

Incidence of simple renal cysts was calculated in 30,316 patients receiving routine ultrasound examination in one hospital, and 170 cases visiting Chiba University Hospital were further analyzed in terms of their clinical features. Incidence of simple renal cyst was 14% in all populations and ratio of male to female was 1.6:1. Patients age ranged from 8 to 92 years (average age 58.6 years) and number of a renal cyst was increased after fifth decade in both sexes. Patients of Chiba University Hospital were examined on symptoms and clinical courses with maximal follow up to 132 months (average 18 months). Symptoms associated with simple renal cysts were: none (75.3%) pain (14.7%) and gross hematuria (6.4%). Urinalysis of patients without associated urinary diseases, showed microhematuria in 40% and proteinuria in 12%, however, grade of microhematuria and proteinuria was not correlated with size of cysts. Number of cysts tended to increase with age. Size of cysts and rate of enlargement were increasing along with age. In any cases, renal function was not and affected nor occurred malignant tumor during follow-up period. Cyst punctures with sclerosing agent were performed in 16 patients, and most of the cysts remained the same as or exceeded their original size. It is concluded that routine follow-up is sufficient in most cases without symptoms, since simple renal cysts increase slowly, and impairment of renal function and progression to malignant tumors do not occur.
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PMID:[A simple renal cyst]. 846 80

Renal tubular acidosis (RTA) is applied to a group of transport defects involving the reabsorption of bicarbonate (proximal RTA or type II), the excretion of hydrogen ion (distal RTA or type I), or both (type III). Aldosteron deficiency and resistant state to aldosteron form hyperkalemic RTA which is called type IV RTA. A large number of etiologies of RTA have been identified. Almost all RTA in childhood are congenital. In contrast, almost all RTA in adulthood are secondary. Two renal complications such as low molecular weight proteinuria and renal cyst formation have recently been described in distal RTA. Molecular defects of RTA will be identified in the near future.
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PMID:[Renal tubular acidosis (RTA)]. 890 39

During the last few years there has been a renewed interest in blood-pressure-induced kidney damage, due to a progressive increase in the incidence and prevalence of hyipertension and vascular diseases as a cause of end-stage renal disease (ESRD). The need to prevent ESRD demands continued efforts to achieve the early identification of persons with hypertension who are at risk and to provide them with effective antihypertensive therapy. Ambulatory blood pressure monitoring (ABPM) has been used successfully to assess blood pressure values and identify risk markers for cardiovascular diseases. A logical approach would be to use it also to identify those for ESRD. For hypertensive and type 1 diabetics ABPM data usually have a stronger correlation to the presence and magnitude of microalbuminuria than do routine office blood pressure measurements. The best Pearson correlation coefficients for relationship between ambulatory blood pressure values and urinary excretion of albumin were obtained with nocturnal blood pressure regardless of whether systolic, diastolic or mean blood pressure were considered. Moreover, high percentages of non-dippers have been found among subjects with renal failure, subjects undergoing dialysis (haemofiltration, peritoneal dialysis, continuous ambulatory peritoneal dialysis (CAPD), subjects with renovascular hypertension and with cystic kidney disease, subjects who have had a kidney transplant and subjects with cyclosporine-induced hypertension. Finally, ABPM seems to be prognostic for development of proteinuria in some refractory hypertensives. Whether higher nocturnal blood pressure values and the non-dipping pattern constitute a cause or are consequences of renal disease should be addressed in prospective studies. Assessment of nocturnal blood pressure seems to be an important tool in the management of patients with hypertensive-related renal disease and of patients who are susceptible to developing it.
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PMID:Ambulatory blood pressure and the kidney. 1021 47

During the last few years there has been a renewal of interest in blood-pressure-induced kidney damage due to a progressive increase in the incidence and prevalence of hypertension and vascular diseases as a cause of end-stage renal disease (ESRD). The need to prevent ESRD demands a continuation of effort to make the early identification of hypertensives who are at risk possible and to provide them with effective antihypertensive therapy. Since ambulatory blood pressure monitoring has been used successfully to assess blood pressure and identify risk markers for cardiovascular diseases, a logical approach would be to use it also to identify the risk markers for ESRD. Higher than normal percentages of non-dippers have been found among subjects with renal failure, during dialysis (haemofiltration, peritoneal dialysis and continuous ambulatory peritoneal dialysis), among cases of renovascular hypertension or cystic kidney disease and among cases of renal transplantation. Although this non-dipping pattern might be related to the presence of severe hypertension in some patients, such as those who have renovascular hypertension, in other cases the abnormal circadian variability is present with milder forms of hypertension or even in the absence of hypertension. Monitoring ambulatory blood pressure could offer advantages for protection of renal function during antihypertensive treatment of subjects with mild renal insufficiency. Furthermore, ambulatory blood pressure monitoring seems to have been prognostic for the development of proteinuria in a group of refractory hypertensives. Whether higher than normal nocturnal blood pressures and the non-dipping pattern are causes or consequences of renal disease should be addressed in prospective studies. The above notwithstanding, assessment of nocturnal blood pressure seems to be an important aid in the management of patients with hypertension-related renal disease and of patients who are susceptible to developing it.
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PMID:Ambulatory blood pressure during diseases of the kidney. 1054 49

Sixty-one patients affected by de Lange syndrome underwent a careful renal and urological evaluation including family and personal history, physical examination, urinalysis, renal tract ultrasonography, and serum creatinine. A voiding cystourethrography was performed in patients with urinary tract infections, in patients with renal ectopy, and in patients with small kidneys. Structural anomalies of the kidney and urinary tract were detected either by ultrasound or voiding cystourethrography in 25 patients (41%): absent or poor corticomedullary differentiation (N = 8; 13%), pelvic dilation (N = 6; 10%), vesicoureteral reflux (N = 5; 8%), small kidney (N = 3; 5%), isolated renal cyst (N = 3; 5%), and renal ectopia (N = 2; 3%). Renal function was normal in 52 patients (85%) but reduced in 9 patients (15%) with renal tract abnormalities. Overt proteinuria was disclosed in three patients with impaired renal function.
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PMID:Anomalies of the kidney and urinary tract are common in de Lange syndrome. 1563 88

Polycystic kidney disease (PKD) is associated with mutations in PKD1 and PKD2 and vascular abnormalities. The links between the epithelial and vascular defects, however, are poorly understood. Vascular endothelial growth factor (VEGF) has been shown to be critical for normal kidney development. In animal models, blockade of VEGF in the perinatal period can lead to abnormal glomerular development, impaired nephrogenesis, proteinuria, and renal failure. We hypothesized that brief blockade of VEGF signaling during early postnatal kidney development can lead to renal cyst development. On days 2 and 4 of life, CD-1 mice were treated with antibodies generated against the extracellular portion of the VEGF receptor 2 (DC101), the area of the receptor where VEGF binding occurs. Mice developed renal cysts between 2 and 3 weeks. The DC101-treated mice also had increased cell proliferation in the renal tubule epithelium. In addition, mice receiving DC101 developed abnormal glomeruli, proteinuria, and patchy cellular infiltrates. Early disruption of VEGFR-2 signaling during the perinatal period results in renal cyst formation, impaired glomerulogenesis, and inflammation. VEGF could be a key link between vascular and cystic changes in kidney cyst formation.
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PMID:VEGF receptor 2 blockade leads to renal cyst formation in mice. 1657 16


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