Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A ten years old boy with severe acute renal failure was presented. The development of acute uremia was proceeded by infectious mononucleosis. Renal biopsy revealed acute tubulointerstitial nephritis. Peritoneal- and haemodialysis was completed by steroid therapy and cytostatic treatment when glomerular proteinuria was observed. Following a 2 months uremic period the patient cured completely.
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PMID:[Successful treatment of acute tubulointerstitial nephritis associated with infectious mononucleosis and causing severe uremia]. 155 26

Plasmodium brasilianum causes chronic quartan malaria in the common marmoset Callithrix jacchus, whereas Epstein-Barr virus (EBV) infection is followed by an infectious mononucleosis-like syndrome that resolves. We infected weanling marmosets with one or both of these pathogens. Timing of the infections influenced outcome. Six animals were simultaneously infected with both agents; four became seriously ill (with accompanying proteinuria and edema) and either died or were killed. Histopathology indicated that glomerulonephritis had developed. The two survivors had more-prolonged parasitemia than did animals infected with P. brasilianum alone, as did animals infected with EBV before P. brasilianum. Five of the six simultaneously infected animals had absent or low titers of antibody to Epstein-Barr viral capsid antigens when compared with the other EBV-infected animals. Our results suggest that combined infection may be part of the etiology of quartan malarial nephropathy.
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PMID:Glomerulonephritis in common marmosets infected with Plasmodium brasilianum and Epstein-Barr virus. 284 17

Four patients (2 were HBsAg positive) with acute icteric viral hepatitis (VH) developed acute renal failure (ARF) in the course of their illness and in the absence of other complications. Their peak serum creatinine values (4.7-10, mean 7 mg/dl) were reached either before or simultaneously with their maximum serum aminotransferase values (1,390-2730, mean 2,032 mU/ml). Apart from VH no other factors responsible for precipitating ARF could be identified. In the HBsAg-negative patients, serological investigations for infectious mononucleosis, cytomegalovirus infection, and leptospirosis were negative. In 2 patients liver biopsy showed changes consistent with VH. Proteinuria was absent in all cases, making glomerulonephritis unlikely. The urinary sodium excretion was uniformly high (57-104, mean 78 mmol/l in random samples). Two patients required short courses of dialysis. All cases recovered completely with return of serum creatinine to normal values after a mean duration of 25 days. After a normal serum creatinine level had been achieved, 1 case was lost to follow-up, and the other 3 cases maintain normal renal and liver function tests 9 months (mean) after the initial episode. Otherwise uncomplicated VH is a potential cause of ARF, even in the absence of severe hepatic insufficiency. The mechanism of ARF in VH is unknown, but vasoconstriction phenomena induced by endotoxemia might contribute.
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PMID:Acute renal failure complicating viral hepatitis in the absence of severe hepatic insufficiency. 406 5

Immune complexes in serum, urinary excretion of albumin and beta-2-microglobulin were determined in patients with infectious mononucleosis, both during the acute stage of the disease and one month later. At the first examination immune complexes were detected in 8 out of 12 patients, using both the ClqBA and the PP-Lc methods, but had disappeared in all after one month. Urinary excretion was initially increased for albumin in one of 9 and for beta-2-microglobulin in 5 of 9 patients. A significant fall in excretion was noted for beta-2-microglobulin during the acute phase (0.486 to 0.190 ng/min (medians), p less than 0.01) whereas albumin excretion did not change significantly (9.0 to 4.0 micrograms/min). Excretions were normal in all patients after one month. The magnitude of proteinuria was not correlated to the serum level of immune complexes. Serum beta-2-microglobulin was initially increased in 8 of 9 patients, but normal after one month (3.8 to 2.2 mg/l, p less than 0.01). There was a significant correlation between levels of beta-2-microglobulin in serum and urine (rho = 0.833, n = 9, p less than 0.01). 51Cr-EDTA clearance was the same during the acute illness and one month later. It is concluded that the abnormalities in urinary protein excretion do not seem to be related to the presence of circulating immune complexes in infectious mononucleosis and that the elevated urinary beta-2-microglobulin excretion is most likely due to increase production.
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PMID:Urinary excretion of albumin and beta-2-microglobulin, glomerular filtration rate and immune complexes in serum during infectious mononucleosis. 618 60

A four-year-old boy developed oliguria, proteinuria and hypocomplementemia, without hematuria, in the course of proven infectious mononucleosis. A chest radiograph revealed a mild cardiomegaly, prominent pulmonary vasculature and pleural fluid. These abnormalities were compatible with acute glomerulonephritis and were in support of this clinical diagnosis in spite of the absence of hematuria.
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PMID:The chest radiograph in the diagnosis of atypical nephritis due to infectious mononucleosis. 650 88

This report describes the first pediatric case of chronic renal failure as a complication of infectious mononucleosis in a 3 1/2 year old girl. The clinical features were marked at onset by proteinuria and later by nephrotic syndrome. The evolution to chronic renal failure took about two years. In the renal biopsy, lesions characteristic of interstitial nephritis were observed, associated with focal and segmental glomeruloesclerosis and deposits of C3 in granular and discontinued form. Renal participation in infectious mononucleosis is not unusual and fundamentally it is manifested by proteinuria and abnormalities of urinary sediment, with interstitial nephritis as a characteristic lesion in the renal biopsy.
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PMID:[Chronic renal insufficiency secondary to infectious mononucleosis]. 663 11

Dapsone, a synthetic sulfone with chemical similarities to sulfapyridine, has been used for a number of years to treat leprosy and dermatitis herpetiformis. Recently, a number of prospective, randomized, double-blind trials have shown their success in the management of rheumatoid arthritis, with dapsone being superior to placebo and comparable to chloroquine and hydroxychloroquine. Its mode of anti-inflammatory actions in rheumatoid arthritis is not clearly understood, but modulation of neutrophil activity or inhibition of neutrophil inflammatory product formation or release appear to play a role. The major limiting side effect is hemolytic anemia, which may be mitigated through careful patient selection, conservative drug dosing, close monitoring, and possibly, concurrent administration of antioxidants or cytochrome P450 inhibitors. Methemoglobinemia is another common finding among patients receiving dapsone therapy, but rarely does it result in prominent symptoms other than transient pallor. Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints. In this report, two patients with advanced rheumatoid arthritis, who were safely and effectively treated with dapsone after failure with other second-line agents, are described and the literature is reviewed. We suggest that dapsone is an effective second-line agent in the treatment of rheumatoid arthritis.
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PMID:Dapsone in rheumatoid arthritis. 879 11

Previous studies have suggested a relationship between reproductive history, pregnancy and birth factors, and the risk of neuroblastoma. We conducted a case-control telephone interview study that included a total of 504 children under the age of 19 years with newly diagnosed neuroblastoma identified by two national collaborative clinical trials groups, the Children's Cancer Group and the Pediatric Oncology Group. A total of 504 controls, matched to cases on age, were identified by random digit dialing. Conditional logistic regression was used to estimate the matched odds ratio (OR) and 95% confidence interval (CI) with adjustment for household income, and maternal race and education. In addition, case subgroups defined by age at diagnosis, tumour MYCN oncogene amplification status, and stage were evaluated. A suggestive pattern of increased risk was seen for a greater number of prior pregnancies, history of previous miscarriages and induced abortions, with nearly a twofold increase in risk for two or more prior induced abortions (OR = 1.9, 95% CI [1.0,3.7]). No association was found for the following diseases or conditions during pregnancy: hepatitis, rubella, measles, mumps, chickenpox, mononucleosis, vaccinations, morning sickness, pre-eclampsia, bleeding, proteinuria, anaemia, urinary tract infections, heart disease, kidney disease, liver disease and diabetes. A weak association was found for hypertension during pregnancy. Several labour and delivery factors were related to an increased risk, including threatened miscarriage, anaesthetic during labour (specifically epidural) and caesarean delivery. We found associations between premature delivery (<33 weeks: OR = 1.9, 95% CI [0.7,4.8]), very low birthweight (<1500 g: OR = 2.6, 95% CI [0.7,10.3]) and risk of neuroblastoma. There was no consistent pattern of increased risk found for most factors within subgroups defined by age at diagnosis, stage or MYCN status.
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PMID:Association of pregnancy history and birth characteristics with neuroblastoma: a report from the Children's Cancer Group and the Pediatric Oncology Group. 1170 80

Cytomegalovirus (CMV) infections have been associated with exacerbations of systemic lupus erythematosus (SLE). Their role in triggering this disease, however, remains a subject of debate. We present a 43-year-old man with no history of systemic illness who developed persistent signs and symptoms of a CMV-associated mononucleosis-like syndrome while fulfilling diagnostic criteria for previously undiagnosed SLE. The patient was admitted with persistent fever for 3 weeks, cervical lymphadenopathy, elevated liver function tests, and leukopenia. Further laboratory studies revealed positive antinuclear antibody, anti-dsDNA, anti-Sm/RNP, rheumatoid factor, and anticardiolipin antibodies along with decreased complement levels and proteinuria of 876 mg/dL. CMV immunoglobulin M was positive in the absence of CMV immunoglobulin G, supporting acute CMV infection. Symptoms improved with intravenous administration of methylprednisolone and ganciclovir therapy. Mechanisms by which CMV may trigger autoimmunity have been proposed, and this case could support CMV infection as a potential trigger for SLE in susceptible individuals.
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PMID:Cytomegalovirus as a trigger for systemic lupus erythematosus. 2085 22

A 21-year-old woman presenting with acute Epstein-Barr virus (EBV) infection (infectious mononucleosis) was noted to have renal involvement. She had proteinuria, leukocyturia and microscopic hematuria, and 10 days after admission became nephrotic (23 g of protein per g of creatinine). Renal biopsy revealed glomerular tuft collapse, visceral epithelial cell proliferation and vacuolization consistent with collapsing glomerulopathy. She had only transient deterioration in renal function, attributed to contrast nephropathy, but after recovery remained proteinuric. Renal disease is well described in EBV infection, but collapsing glomerulopathy has not been reported previously.
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PMID:Acute Epstein-Barr virus infection-associated collapsing glomerulopathy. 2587 88


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