Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033687 (proteinuria)
 24,015 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Under ultrasound guidance, we treated 25 cases of renal cyst with 99% ethanol instillation to prevent the recurrence of this disease from January 1985 to June 1987. Patients' age was from 17 to 85 years old with the average age of 63 years. Twelve cases were men, and 13 cases were women. Among the 25 cases, eleven were asymptomatic and 14 showed clinical features of lumbago, microhematuria, hypertension or proteinuria. The aspirated site was the right side in 9, left side in 14 and bilateral kidneys in 2 cases. Subsequently, cyst puncture was carried out 27 times. We encountered 12 complications following puncture. These complications were derived from the puncture itself or caused by the ethanol instillation. Flank pain caused by the injection of ethanol, nausea, causalgia or a feeling of drunkenness appeared immediately after the inoculation procedure. However, no serious complications such as pneumothorax, perirenal hematoma or infection were recognized. Some complications arose in 7 cases of 9 examples (77.8%) following more than 50 ml of ethanol injection, but the complications were observed in only 5 cases of 18 examples (22.8%) following less than 50 ml of administration. Based on these findings, ethanol injection in renal cysts appears to be useful for the treatment of this disease. In case of huge cysts when more than 50 ml of ethanol, is instilled the case should be followed up carefully after the instillation procedure.
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PMID:[Renal cyst puncture under ultrasound guidance: complications of ethanol injection]. 306 4

In the pregnant tethered sow, water intake and motor activity were found to be related to urinary problems and productivity. Therefore, further studies were undertaken on these points. The 258 pregnant sows from eight breeding finishing herds were submitted to water intake control and the investigation of motor activity was performed on 125 pregnant sows from 6 herds. Despite the same process of water supply, the intake varied a lot from sow to sow (mean: 17 litres/day/pregnant sow, (sigma = 6.9 l). The major part of water was drunk during feeding time. The following factors were found associated with water intake: body condition, lameness, parity, stage of pregnancy. The relations between water intake and urine composition were assessed. A low water intake was close related to high urine gravity and to abnormalities (crystals, proteinuria, bacteriuria). The pregnant tethered sows spent an average time of 250 min in the standing position. A diurnal rhythm was clearly observed and it was synchronized by feeding time. The following factors were found to be related to the standing time: parity, body condition, lameness. The frequency of standing up per 24 hours was not related to the total standing time. Under farm husbandry, standing time is rather inconstant in individual sows on subsequent days. Since photo cell apparatus cannot be used as a routine in veterinary practice, we have looked for a more simple method: the position of the sows one hour after feeding time. This index gave an accurate view of the total standing time and represented a practical parameter for epidemiological purposes. The relevance of measuring water intake and motor activity in veterinary practice is discussed.
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PMID:Relevance of some behavioural criteria concerning the sow (motor activity and water intake) in intensive pig farming and veterinary practice. 377 11

Wistar rats with surgically removed 5/6 of renal parenchyma were fed either standard (0.35% salt content) or a high-salt (2%) diet. Half of the animals of each group drunk plain water while the other half was provided water enriched with the angiotensin-converting enzyme inhibitor enalapril (ENA) at a dose of 5 mg/kg/day. In rats receiving standard diet, ENA had a significant inhibitory effect on the consequences of ablation: the rats had normal blood pressure, low proteinuria, and high endogenous creatinine clearance compared to water-drinking controls. The high-salt diet significantly enhanced the sequelae of ablation: a high blood pressure and proteinuria, low clearance, which ENA was unable to prevent in these animals. No plausible explanation for the absence of ENA's beneficial effect is available: one can speculate that, under conditions of high-salt intake, the activity of the renin-angiotensin system is suppressed leaving no place for ENA to exert its effect. We also believe that the highly adverse effect of a high-salt diet in chronic renal failure is due to growth factors other than angiotensin II.
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PMID:[Ineffectiveness of ACE inhibitors (enalapril) on glomerular damage in rats after a 5/6 nephrectomy and a high-salt diet]. 776 86