Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors report a 42-year-old patient with excruciating pains felt in the interscapular and lumbar regions and both lower extremities without symptoms of root involvement. Myelography suggested presence of a tumour of the conus medullaris or epidural tumour in this area, at the Th12--L1 level. During the operation a central prolapse of the nucleus pulposus was found in the midline on the anterior wall of the vertebral canal below the longitudinal ligament. After operation all symptoms disappeared and the patient resumed work.
Neurol Neurochir Pol
PMID:[Central prolapse of the Th12 -L1 nucleus pulposus with radiological signs of tumor of the conus medullaris]. 47 Nov 65

Trazodone, an antidepressant drug with an unknown mechanism of action, has been examined in order to demonstrate its central antiserotonin action. Trazodone antagonizes the head twitch response induced by 5-hydroxytryptophan in rats and mice, or by-5-methoxytryptamine in rats (the ED50 values are 9.3, 5.2, and 10.8 mg/kg respectively). It counteracts convulsions induced by tryptamine in rats (ED50=3.75 mg/kg). Trazodone abolishes hyperthermia induced by serotoninomimetics (LSD, quipazine, fenfluramine) in rabbits. It does not affect ptosis induced by reserpine, and diminishes stimulation of the locomotor activity induced by amphetamine. Our findings demonstrate that trazodone has a central antiserotonin action, similarly as three other antidepressant drugs: mianserin, danitracen and doxepin, whose central antiserotonin action has been found previously.
Pol J Pharmacol Pharm
PMID:On the central antiserotonin action of trazodone. 48 64

In a group of 300 patients with the diagnosis of lumbar nucleus pulposus prolapse treated surgically the authors found in 4 cases not the expected prolapse but varicose blood vessels surrounding the nerve roots and immobilizing them in adhesions. In another 5 patients vertebral canal varicosities were associated with nucleus pulposus prolapse. None of these cases of vertebral canal varicosities had been diagnosed before operation since the clinical state of these patients was not significantly different from the state of patients with nucleus prolapse and radiculography failed to supply sufficient diagnostic data or suggested presence of small prolapse. An auxiliary diagnostic finding in cases of vertebral canal varices may be frequent association of spinal anomalies (in 3/4 of the observed cases) and obesity (in 2/3 of cases). Surgical decompression of vertebral canal and liberation of roots from adhesions without excision or ligation of varicose veins gave good therapeutic results.
Neurol Neurochir Pol
PMID:[Varicosity of the lower part of the vertebral canal]. 63 33

The author studied electromyographic findings and surgical exploration results in 37 women and 63 men operated upon for nucleus pulposus prolapse. EMG investigations of paravertebral muscles were found to be useful in the diagnosis of motor root lesions. A correlation was found between the size of prolapse and the area of denervation potentials in paravertebral muscles. On the other hand, it was found that these investigations do not indicate accurately the level of nucleus pulposus prolapse.
Neurol Neurochir Pol
PMID:[Usefulness of electromyographic examinations of paravertebral muscles in patients with lumbosacral root compression syndrome]. 95 74

Ergometrine, a spasmolytic which also stimulates dopamine receptors, was investigated as a potential central stimulant. It did not influence the locomotor activity of normal rats and mice, and in high doses even depressed it. The locomotor activity depressed by reserpine, spiroperidol, and pimozide was elevated by ergometrine. Ergometrine antagonized neuroleptic-induced catalepsy and abolished ptosis and hypothermia produced by reserpine. Given alone ergometrine depressed the body temperature in rats and mice, and this effect was abolished by pimozide in both species, and by spiroperidol and haloperidol in mice. The hypothermia was not antagonized by atropine. In several respects the central action of ergometrine resembles that of apomorphine.
Pol J Pharmacol Pharm
PMID:Central action of ergometrine. 103 20

In 50 patients with lumbar nucleus pulposus prolapse the force of femoral abductors was determined by the test of Lovett and by means of dynamometric measurements. In 90% of patients paresis of these muscles was found. A comparison of the incidence of other signs of nerve root damage such as paresis of plantar and dorsal flexion of the foot and toes, sensory impairment on the foot and lack or weakness of ankle jerk showed that paresis of fermoral abductors was most frequent among them. This fact is explained by a particular predisposition for development of uncleus pulposus prolapse at the level of 4th and 5th intervertebral discs with resulting injury to the nerve roots L4, L5, and S1 innervating femoral abductors. The authors think that paresis of femoral abductors may be a pathognomonic sign in the diagnosis of nerve root lesions caused by nucleus prolapse at the levels L4-L5 or L5-S1. The frequency of paresis and the degree of weakness indicate the necessity of motor rehabilitation of this music group in comprehensive treatment of patients with lumbar disc prolapse.
Neurol Neurochir Pol
PMID:[Force of femoral abductors in patients with lumbar nucleus pulposus prolapse]. 115 63

Clinical investigations and plain film of the spine are not sufficient for diagnosis of three-level lumbar nucleus pulposus prolapse. Contrast investigations, especially radiculography with television monitoring, are particularly suitable for demonstration of multiple prolapses. In a material of 730 cases two-level prolapse was found in about 12% of cases and three-level prolapse in about 0.5% of cases and this suggests that radiculography should be carried out routinely before each operation for lumbar nucleus pulposus prolapse.
Neurol Neurochir Pol
PMID:[Diagnosis of 3-level lumbar nucleus pulposus prolapse]. 125 36

The authors present the case of mitral valve prolapse. In a young woman with three-year history of systematically treated epilepsia mitral valve prolapse with a spurious string within left ventricle has been diagnosed echocardiographically in coincidence with the symptoms of haemorrhagic diathesis of von Willebrand type in form of haemoptysis and or/massive haemorrhages in mouth occasionally being preceded by heart rhythm disturbances. No local changes have been observed in otorhinolaryngologic examination, bronchoscopy and gastroscopy. Possible mutual dependence of 3 above stated abnormalities is being discussed. It is not excluded, that mitral prolapse may constitute the primary entity and epilepsia is of secondary character as a result of cerebral ischaemic incidents or of cerebral embolism. It is also a matter of discussion to what extent abrupt haemodynamic disturbances connected with critical fall of systemic blood pressure due to mitral prolapse may influence the haemorrhagic episodes.
Pol Tyg Lek
PMID:[Coexistence of von Willebrand's disease with mitral valve prolapse]. 130 May 78

Video-laparoscopic colpopexy is an innovative procedure. This study included 15 post-hysterectomy with vaginal prolapse. The surgical technique has been described in detail.
Ginekol Pol 1992
PMID:Laser video-laparoscopic colpopexy. 130 35

Electrophysiological tests were performed in 60 patients aged between 18 and 63 years (mean age 38 years), and divided into two groups: with mitral valve leaves prolapse syndrome, and without this abnormality, in whom no other heart disease was diagnosed. Refraction of the right atrium, atrio-ventricular node, and right ventricle was evaluated together with cardiac response to different types of electrostimulation. A supraventricular dysrhythmia (most frequently atrial fibrillation) has been produced in 17 patients (42.5%) with mitral valve leaves prolapse syndrome whereas in the control group the same was produced in 2 patients (10%). Programmed stimulation of the ventricles did not produce ventricular tachycardia in none patient of both groups. Multiple ventricular beats have been produced in 3 patients with mitral valve prolapse syndrome and pairs of ventricular beats in other 3 patients of this group. Results suggest that "arrhythmogenic tendency", especially supraventricular dysrhythmia is more frequent in patients with mitral valve prolapse syndrome than in the general population.
Pol Tyg Lek
PMID:[Programmed atrial and ventricular stimulation in patients with mitral valve prolapse--a personal experience]. 143 74


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