Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Anticonvulsants remain necessary during pregnancy and the removal of such drugs is not recommended. However, on the available evidence, the physician may expect an increased risk of malformation including eye abnormalities as has been outlined. The abnormalities include growth deficiencies and delayed motor/mental development together with dysmorphic features, the most common of which seems to be cleft lip/cleft palate. Additionally, many of these children suffer from eye abnormalities including hypertelorism, ptosis, strabismus, epicanthal folds, and in this case abnormalities of the lacrimal apparatus.
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PMID:Multiple systemic and periocular malformations associated with the fetal hydantoin syndrome. 10 74

The case report of a 20 year old woman illustrates the course of blepharochalasis. This disease was defined as an entity by E. Fuchs in 1896. It is characterized by relapsong edematous tumefaction and increasing relaxation of the eye lids with atrophy of the skin, blepharophimosis and emergence of a pseudoepicanthus. Folding of the oral mucosa in the upper lip, the so-called double lip, euthyroid struma, and, in later stages, orbital fat hernia and prolapse of the lacrimal gland, are further facultative symptoms. Partially, late stages of the disease had been described as Ascher- or Laffer-Ascher-Syndrome. This syndrome is no separate entity.
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PMID:[Blepharoachalasis (Fuchs) and the Laffer-Ascher syndrome]. 56 95

Herniation of the lacrimal gland is a condition that occurs unilaterally or bilaterally. Either or both lobes of the lacrimal gland may prolapse. Orbital lobe prolapse may be associated with blepharochalasis, a disease of puberty. We developed a surgical technique for the repair of prolapsed lacrimal glands. It is important to have adequate hemostasis and closure of the orbital septum.
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PMID:Surgical repair of prolapsed lacrimal glands. 62 40

Ip methoxamine (Met), norepinephrine (NE), xylazine (Xyl), and clonidine (Clo) produced dose-related reversal of ptosis induced by reserpine. These agonists had equivalent Emax values, however, the order of potency was: Clo greater than Met approximately NE greater than Xyl. Met-induced antiptotic action was competitively inhibited by prazosin (Pra) (apparent pA2 = 6.86), but not by idazoxan (Ida); Xyl-induced antiptotic action was competitively inhibited by Ida (apparent pA2 = 6.39), but inhibited by Pra in a noncompetitive manner. These results suggested that the eyelids of mice had both alpha-1 and alpha-2 adrenoceptors. In mice lacrimal gland, Met, and NE elicited dose-related lacrimal secretions, however, Xyl and Clo had no such reaction. Lacrimal secretions elicited by Met or NE were inhibited by Pra, but not by Ida. These results suggested that the lacrimal gland of mice had only alpha-1 adrenoceptor.
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PMID:[Effects of alpha adrenoceptor agonists and antagonists on palpebral fissure and lacrimation in mice]. 135 Aug 80

We describe a 3-generation family with lacrimo-auriculo-dento-digital syndrome (LADD). In addition to the well described abnormalities of ears, teeth, lacrimal apparatus and digits, the patients exhibit several previously undescribed anomalies, including minor facial anomalies (broad forehead, telecanthus, bulbous nasal tip, full jaw, ptosis and flared nostrils), involvement of the first and second toes, and congenital renal disease causing death in the neonatal period in 2 cases.
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PMID:Lacrimo-auriculo-dento-digital syndrome: evidence for lower limb involvement and severe congenital renal anomalies. 141 42

We retrospectively reviewed the complication rate associated with silastic tube intubation in the treatment of congenital and acquired obstructions of the lacrimal system in 82 patients with a follow-up of 3 to 66 months. Complications included tube prolapse, extrusion or breakage, punctal erosion, conjunctival irritation, intranasal discomfort, and tube inspissation with mucoid debris ("dirty tubes"). The rate was highest in the first 3 months (41%); it decreased to less than 10% after 6 months. Based on these findings, we recommend that silastic nasolacrimal tubes be regarded as semi-permanent devices which may safely be left in place for years.
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PMID:Long-term placement of silastic nasolacrimal tubes. 164 12

The potential antidepressant effect of flerobuterol (dl-(fluoro-2 phenyl)-1 t-butylamino-2 ethanol), a new drug related to beta-adrenoceptor agonists, was evaluated and compared with imipramine and salbutamol using classical psychopharmacological tests in mice. Like imipramine and salbutamol, flerobuterol (0.5-32 mg kg-1, ip) fully prevented apomorphine (16 mg kg-1, sc)- and partly reversed reserpine- and oxotremorine-induced hypothermia. At higher doses (16-32 mg kg-1), flerobuterol enhanced the toxic effects of yohimbine. Unlike imipramine, flerobuterol and salbutamol did not reduce immobility duration in the behavioural despair test. Salbutamol and flerobuterol decreased locomotor activity. Flerobuterol did not induce mydriasis, did not prevent oxotremorine-induced tremors or salivary and lacrimal gland secretion and did not reduce reserpine-induced palpebral ptosis. Propranolol (8 mg kg-1, ip) but not alpha-methyl-paratyrosine (75 mg kg-1, ip) prevented the flerobuterol-induced antagonism of apomorphine-induced hypothermia. Our results suggest that flerobuterol demonstrates potential antidepressant activity, which could be related to beta-adrenoceptor activation in mice.
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PMID:Flerobuterol: a potential antidepressant drug related to beta-adrenergic agonists. Experimental profile in mice. 168 9

The paper presents a family with 28 members belonging to four generations. 12 of them show an association of blepharophimosis--ptosis--dystopia of the inferior lacrimal points and epicanthus. 9 members of the family in the 3rd and 4th generations were examined and a dominant mode of transmission was evidenced.
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PMID:[The syndrome of blepharophimosis-ptosis-dystopia of the inferior puncta lacrimalia and epicanthus]. 181 41

A case of exceedingly rare mycobacterial infection following blepharoplasty is recorded. This nursing home employee underwent a combined blepharoplasty, eyelid ptosis correction, and replacement of breast implants. One month later, she developed localized abscesses of both eyelids. Cultures revealed nontuberculous mycobacterial infection. The infection was controlled after ten months of antibacterial therapy using doxycycline. We believe that the patient's exposure to debilitated individuals due to her nursing profession and the presence of a Jones tube in the right lacrimal system were major contributing factors.
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PMID:Mycobacterial infection following blepharoplasty. 189 16

This paper presents the findings in a series of 30 patients with blepharochalasis, including the age of onset, sex, predisposing factors, symptoms and signs, frequency and duration of attacks, and length of the history. There were 16 bilateral and 14 unilateral cases. The condition can be divided into an active (early) and a quiescent (late) stage. The active stage is further subdivided into intumescent (hypertrophic) and atrophic forms. The sequelae included excess thin skin, fat herniation, lacrimal gland prolapse, ptosis, blepharophimosis, pseudoepicanthic fold, proptosis, conjunctival injection and cysts, entropion, and ectorpion. Surgery primarily involved blepharoplasty, ptosis correction, and lateral canthal reattachment alone or in combination. The pathology showed a variable picture of epithelial atrophy, vasculitis, and loss of elastic fibers, which did not greatly help to differentiate blepharochalasis from angioedema, lymphedema, dermatochalasis, tumors and infiltrations, and floppy lid syndromes. Blepharochalasis is probably a localized angioedema. The diagnosis depends on the clinical features of intermittent attacks of localized swelling affecting one or more eyelids associated with thinning of the skin giving either an intumescent (hypertrophic) or atrophic appearance in the active stage of the condition and progressing to atrophic changes in the quiescent (late) stage.
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PMID:Blepharochalasis. A review of 30 cases. 191 19


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