Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to examine the production mechanism of the midsystolic click in cases of a midsystolic click and a late systolic murmur, the relationship between the click and the motion of the mitral apparatus was studied by means of ultrasono-cardiotomography and the simultaneous recording of phonocardiograms and ultrasono-cardiograms (UCGs). It was found that the systolic click occurred in exact coincidence with the time at which the hump of the echo of the unusual early systolic anterior motion (early SAM) took its backmost position. This coincidence was found when the click was shifted either by postural changes or inhalation of amyl nitrite. The present ultrasono-cardiotomographic study demonstrated that the echo source of the early SAM could be attributed to the protrusion into the left ventricular outflow tract of the slackened elongated chordae tendineae in systole. The anterior leaflet moved suddenly to the position of maximal prolapse when the slackened chordae tendineae were stretched taut in midsystole. In other words, the midsystolic click occurred when the anterior leaflet prolapsed and the tension exerted on the chordae tendineae was at its maximum.
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PMID:Mechanism of production of midsystolic click in a prolapsed mitral valve. 92 11

In a 49-year-old male patient surgical treatment of hypertrophic obstructive cardiomyopathy (HOCM, clinical grade III, NYHA) by means of transaortic myotomy and myectomy was performed in November 1979. 6 months later the M-mode-echocardiogram revealed a distinct systolic anterior motion of parts of the mitral valve apparatus (SAM) as well as a marked holosystolic mitral valve prolapse (MVP). The two-dimensional echocardiographic examination demonstrated that the "SAM"-phenomenon was caused solely by chordae tendineae of the anterior mitral leaflet, while the prolapse was due to the posterior mitral leaflet itself.
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PMID:[Holosystolic mitral valve prolapse and "SAM" after surgical treatment of hypertrophic obstructive cardiomyopathy (author's transl)]. 719 57