Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Anchoring of spinal cord at S2 level is described in a female patient aged 46, associated with bilateral equinovarus deformity and spina bifida in lumbar segment. The onset of the disease was sudden due to prolapse of intervertebral disc at L2-L3 and L3-L4 levels followed by bilateral flaccid-spastic paraparesis. In view of congenital spinal deformity lumbar tap was abandoned and MRI was carried out which showed spinal cord reaching down to S2 level. Diagnostic and therapeutic management is described and literature review is presented.
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PMID:[Spinal cord anchored at S2 level: diagnosis difficulties and risks]. 1159 30

Colostomy prolapse is a major cause of morbidity in paediatric patients with Hirschsprung's disease and anorectal malformations. Although it is commonly associated with the distal loop of a transverse colostomy, a sigmoid stoma can also be affected. We report six babies with anorectal malformations between day 10 and 6 months presenting with incessant crying and irritability following prolapsed colostomy stomas. In four patients only the distal stomas were involved but in the other two both proximal as well as distal loops had prolapsed. All the babies had poor oral intake and had bleeding from the prolapsed stomas. Manual reposition with sedation did not help. After reducing the prolapsed part a no. 7 or 7.5F Romsons tracheostomy tube was introduced through the stoma. A cotton tap (16-mm wide) was tied to the flanges of the tracheostomy tube and fastened around the flank for proper fixation. None of the babies had further prolapse and were passing stool through the tube. The tubes were kept for an average period of 4(1/2) (3-9(1/2)) months. Only one patient had frequent displacement of the tube, which the mother learned to reposition without any other problems. We feel that this non-operative simple procedure can be used for treatment of massive colostomy prolapse without any complications. Parents can learn this procedure easily thus avoiding frequent hospitalisation and other invasive procedures.
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PMID:A novel, easy, non-operative method of treating prolapsed colostomy. 1981 94

Tuberculous meningitis (TBM) remains the most dangerous form of tuberculosis with high mortality and potential complications. The prompt diagnosis and treatment of this condition remains a key for better prognosis. A 39-year-old woman presented with severe headache, fever, nausea and vomiting, with a history of headache for a month. On examination, confusion, neck rigidity, ptosis and upward plantar reflexes were present. After 7 days of empiric treatment without resolution of her symptoms, she had another spinal tap performed. The diagnosis of TBM was performed by the GeneXpert MTB/RIF assay from her cerebrospinal fluid (CSF). Antitubercular chemotherapy was started. The patient subsequently improved. Where available, the GeneXpert assay should be used immediately in CSF samples of patients suspected of TBM as an adjunct to clinical algorithms to increase the chance of a prompt diagnosis and treatment.
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PMID:GeneXpert MTB/RIF assay as initial test for diagnosis of tuberculous meningitis. 2607 38