Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of this study is to validate the International Consultation on Incontinence Questionnaire-Vaginal Symptoms (ICIQ-VS) in Portuguese. Two hundred four women (108 symptomatic, 94 asymptomatic, and two with no data) with mean age of 55.4 years received a Portuguese version of the ICIQ-VS. Clinical data and pelvic organ prolapse quantification index (POP-Q) were obtained. Retest was performed 3 weeks later. Responsiveness was assessed after 20 weeks of postsurgical follow-up. Overall, most patients presented POP-Q > 2. ICIQ-VS demonstrated good psychometric properties (validity, reliability and responsiveness). The test-retest reliability was moderate to excellent for all questions. The construct validation distinguished differences in ICIQ-VS scores between symptomatic (ICIQ-VS5a > 0) and asymptomatic (ICIQ-VS5a = 0) women. ICIQ-VS was highly responsive to surgical treatment and discriminated between levels of change in the vaginal symptoms score, sexual matters score, quality-of-life score, and POP-Q. The Portuguese version of ICIQ-VS was successfully validated.
 ...
PMID:The Portuguese validation of the International Consultation on Incontinence Questionnaire-Vaginal Symptoms (ICIQ-VS) for Brazilian women with pelvic organ prolapse. 1850 83

The objective of this study was to report the initial anatomic, radiographic, and genetic evaluations of a novel form of spontaneous pelvic organ prolapse (S-POP) in mice. We observed S-POP in a colony of UPII-SV40T transgenic mice developed for studies on bladder cancer. We utilized magnetic resonance imaging and necropsy to characterize this finding. We have established a breeding colony to identify inheritance patterns and for future studies. Selective breeding isolated the S-POP phenotype from the transgene. In contrast to other animal models, the S-POP mouse does not require an obligatory antecedent event to manifest pelvic organ prolapse. Necropsy and imaging demonstrate significant displacement of the pelvic organs distal to the pelvic floor in both sexes. The appearance of the POP is similar to that seen in the human female phenotype. Preliminary breeding studies indicate an autosomal dominant inheritance pattern. This mouse may be an effective animal model for the study of POP in humans.
 ...
PMID:Inherited pelvic organ prolapse in the mouse: preliminary evaluation of a new murine model. 1880 54

Forty-seven women participated in a pilot study for a multi-centre randomized controlled trial of the effectiveness of pelvic floor muscle training (PFMT) for women with prolapse. Women with symptomatic stage I or II prolapse [measured by Pelvic Organ Prolapse Quantification (POP-Q)] were randomized to a 16-week physiotherapy intervention (PFMT and lifestyle advice; n = 23) or a control group receiving a lifestyle advice sheet (n = 24). Symptom severity and quality of life were measured via postal questionnaires. Blinded POP-Q was performed at baseline and follow-up. Intervention women had significantly greater improvement than controls in prolapse symptoms (mean score decrease 3.5 versus 0.1, p = 0.021), were significantly more likely to have an improved prolapse stage (45% versus 0%, p = 0.038) and were significantly more likely to say their prolapse was better (63% versus 24%, p = 0.012). The data support the feasibility of a substantive trial of PFMT for prolapse. A multi-centre trial is underway.
 ...
PMID:A randomized controlled trial of pelvic floor muscle training for stages I and II pelvic organ prolapse. 1880 10

To determine the relationship between pelvic organ prolapse and spinal curvature changes, a cross-sectional study was done in Gynecologic and Obstetrics educational hospitals and clinics in North West of Iran. One hundred patients were classified as cases based on the presence of abnormality at the spinal curvature and 100 patients classified as controls with no abnormality. The POP-Q (pelvic organ prolapse quantitation) staging system was used for assessment of prolapse stage and a flexi-curve malleable rod for measurement of thoracic and lumbar length and width, respectively. Main outcome was the stage of prolapses. The stage of prolapse was higher in cases compared to controls. There was a significant statistical difference between prolapse stage in two groups (p-value = 0.035). Among cases, grade II prolapse was the most prevalent abnormally (56%) and the grade III, I and IV were observed in 32, 5 and 7%, respectively. These observations underline the importance of taking into account the abnormal changes in spine curvature of patients when investigating risk factors for development of pelvic organs prolapse.
 ...
PMID:Abnormal spinal curvature as a risk factor for pelvic organ prolapse. 1908 74

Sexual well-being is an important parameter of women's health and quality of live. Sexual disorders may occur in women with pelvic organ prolapse and/or stress urinary incontinence and also after pelvic reconstructive surgery. Sexual dysfunction after POP or SUI surgery has been poorly documented but new condition specific questionnaires have been developed to help us to better evaluate such consequences. This paper reports available data and highlights more specifically consequences of surgery with mesh reinforcement which is, currently, an important issue particularly when performing by vaginal approach.
 ...
PMID:[Sexual outcome after pelvic reconstructive surgery]. 1923 4

The focus of improving health care outcomes today relies on utilizing evidence-based practice. Pelvic organ prolapse affects women of all ages and negatively impacts their quality of life. Evidence-based tools for consistent assessment of prolapses have been developed, validated, and used by many clinicians. Use of these tools needs to become standard of practice for all clinicians who work in the women's health arena. The Brink scale and the POP-Q assessment tool can assist clinicians, direct quality care, and provide evidence-based practice.
 ...
PMID:Improving evidence-based practice: use of the POP-Q system for the assessment of pelvic organ prolapse. 1971 36

A fifty-three-year-old vaginally primipara was evaluated for urinary mixed incontinence symptoms and POP-Q stage II pelvic organ prolapse. Her past medical history was significant for Burch colposuspension conducted six years prior to her referral. Review of the operative report indicated prior use of six peri-urethral gortex sutures attached to Cooper's ligament. There was no documentation of cystoscopy at the end of the procedure. Following the surgery, the patient had persistent stress urinary incontinence symptoms and multiple episodes of poorly documented urinary tract infections. After evaluation for worsening symptoms of mixed urinary incontinence and symptomatic proLapse, the patient underwent a suburethral rectus fasciaL sling and sacrocolpopexy for her pelvic organ prolapse. FoLlowing an uneventful procedure, cystoscopy to document Lower urinary tract safety revealed a urothelial-covered gortex suture and tissue bridge in the bladder. The gortex suture was found to be attached to Cooper's ligament, consistent with patient's prior history of Burch colposuspension. Via the open abdominal incision, the intravesical suture was cut at its connection to Cooper's ligament. Through a transvesical approach, the intravesical suture and tissue bridge were incised and removed. The postoperative course was uneventful. This case report emphasizes the importance of intraoperative cystoscopy following an incontinence procedure. This abnormal appearance of the bladder lining is consistent with intravesical surgical materials complications. Intravesical surgical materials may contribute to persistent urinary symptoms or recurrent urinary tract infections (UTIs) in selected women. Detection and removal of these materials is recommended.
 ...
PMID:[A surprise in the bladder: the case of the misplaced gortex]. 1984 29

In the past, hysterectomy was routinely performed at the time of pelvic organ prolapse repair. Nowadays, in patients with abnormal uterus (fibroma, dysplasia...), hysterectomy should be performed at the time of surgery. In contrast, in young women especially with desire of childbearing, uterus preservation is the best choice. But there is still a debate in postmenopausal patients with normal uterus and POP. There is currently no argument for choosing hysterectomy or uterus preservation at the time of POP repair in regard of the anatomical results for the middle as well as the anterior and posterior compartments. But it has been proven that hysterectomy increased the perioperative morbidity. Subtotal hysterectomy decreases this morbidity and result in a decreased rate of mesh erosion. To date, literature is not conclusive about the impact of hysterectomy on lower urinary tract symptoms. Patient's counselling is important before hysterectomy with adequate information about potential psychosexual consequences of such procedure. At least, if uterus preservation, patients must be aware of the risk of malignant diseases (cervix or endometrial carcinoma) even if the risk is low in case of a good screening preoperatively.
 ...
PMID:[The role of hysterectomy during the repair of prolapse by promonotofixation]. 1996 71

Sexual well-being is an important parameter of women's health and quality of live. Sexual disorders may occur in women with pelvic organ prolapse and/or stress urinary incontinence and also after pelvic reconstructive surgery. Sexual dysfunction after POP or SUI surgery has been poorly documented but new condition specific questionnaires have been developed to help us to better evaluate such consequences. This paper reports updated data and highlights more specifically consequences of surgery with mesh reinforcement which is, currently, an important issue particularly when performing by vaginal approach.
 ...
PMID:[Sexual outcome after pelvic organ prolapse surgery]. 1996 76

Between August 2007 and May 2009, 28 patients with uterovaginal prolapse, stage 2 or greater, and who desired uterine preservation, underwent laparoscopic extraperitoneal uterine suspension to the anterior abdominal wall bilaterally using mesh. The primary outcome was recurrence, which was evaluated using point C. Secondary outcomes were effects on quality of life (Pelvic Floor Distress Inventory [PFDI-20] and Pelvic Floor Impact Questionnaire [PFIQ-7]) and sexual symptom (Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire [PISQ-12]) scores, operative time, blood loss, duration of hospitalization, and adverse events. After surgery, there was significant improvement in all pelvic organ prolapse quantification (POP-Q) measurements. The POP-Q score for point C was significantly farther from the hymen at 6-months and 1-year follow-up compared with the preoperative value (-7.8 and -8.0 vs 2.6, respectively; p < .001). The objective cure rates at 6 months and 1 year were 96.4% and 94.1%, respectively. There were no major intraoperative or postoperative complications. However, all patients reported postoperative dragging pain at the points of puncture ports where the mesh was fixed to the abdominal wall. The mean visual analog scale decreased from a mean (SD) 3-day score of 2.61 (1.26) to 0 at 1 month follow-up. Baseline PISQ-12 score changed significantly compared with the value at 6 months after operation (28.4 [2.7] vs 29.3 [2.9]; p < .001). The PFDI-20 and PFIQ-7 scores at 6 and 12 months after surgery improved significantly compared with the baseline scores (p < .001). The subjective success rates at 6 months and 1 year were 96.4% and 94.1%. respectively. Laparoscopic extraperitoneal uterine suspension to the anterior abdominal wall using mesh is a simple, safe, and effective procedure for treating uterovaginal prolapse. However, further studies of the long-term efficiency and reliability of this technique are needed to evaluate its value.
 ...
PMID:Laparoscopic extraperitoneal uterine suspension to anterior abdominal wall bilaterally using synthetic mesh to treat uterovaginal prolapse. 2059 51


<< Previous 1 2 3 4 5 6 7 8 Next >>