Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To study valvular lesions in the acute phase of Kawasaki disease, 17 patients who were admitted to our institution before the 12th day of their illness were examined using real-time two-dimensional Doppler flow imaging (2DD: Toshiba SSH 65A) from January to September 1986. Pulsed Doppler, continuous wave Doppler, and M-mode echocardiography were also performed. Patients were examined daily from their admission to 12th day of illness, and after that, more than twice a week until the 28th day of illness. Fourteen of the 17 patients underwent Ga-67 scintigraphy. Cardiac catheterization, including selective coronary arteriography, was performed in 15 patients in the convalescent phase. Mitral regurgitation (MR) was detected in eight of the 17 cases (47%). MR appeared on 2DD 7.5 +/- 1.6th day of illness (mean +/- SD), lasting until 11.9 +/- 5.7th day of illness. MR was transient and mild in degree in all cases, and the regurgitant jet was directed towards the left atrial posterior wall. Neither prolapse nor deformity of the mitral valve was detected. The left ventricular volume indices (determined by the Pombo method) measured by M-mode echocardiography in the acute and convalescent phases were compared. In the group with MR in the acute phase, the end-diastolic volume index was 66.9 +/- 19.9 ml/m2 and the end-systolic volume index was 21.0 +/- 11.7 ml/m2. These were significantly greater than those in the convalescent phase (51.3 +/- 13.1 ml/m2, 14.1 +/- 4.0 ml/m2, respectively). However, no significant differences were observed in the group without MR. Positive uptake of Ga-67 was observed in six patients with MR, but in none of the seven without MR. The incidence of positive uptake was significantly higher in the patients with MR. Cardiac catheterization performed in the convalescent phase revealed that no patient had the findings of MR, other valvular lesions, coronary arterial lesions, or abnormal ventricular performance.
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PMID:[Mitral regurgitation in the acute phase of Kawasaki disease: scrutiny using real-time two-dimensional Doppler flow imaging]. 345 48

Ten youngsters with conal ventricular septal defect (VSD) and aortic regurgitation (AR) were studied by pulsed Doppler echocardiography (PDE). The ATL pulsed Doppler echocardiogram system combined with Toshiba SSH-11A cross-sectional echocardiographic system was used. The diagnostic findings of PDE for conal VSD was a systolic turbulent flow in the right ventricular outflow tract (RVOT) and the conus septum which was just in front of the aortic valve. The diagnosis of AR was obtained by a diastolic turbulent flow in the left ventricular outflow tract (LVOT) and an away flow in the ascending aorta which was recorded from the suprasternal notch. After confirmation of the diagnosis of conal VSD with AR by cardiac catheterization and angiography, operations were performed in all 10 cases. In 9 cases PDE revealed the systolic turbulent flow in the RVOT which cone through conal VSD. The systolic turbulent flow in the conus septum was detected in 5 cases. The diastolic turbulent flow in the LVOT due to AR was detected in all 5 cases of mild AR (1 degrees by Sellers). In all cases, the diastolic turbulent flow in the LVOT was detected near the anterior mitral leaflet. This localization of the diastolic turbulent flow may be due to the prolapse of the right coronary cusp. Spread of the diastolic turbulent flow in the LVOT could document the degree of AR. In 2 cases, PDE was recorded in the ascending aorta from the suprasternal notch. The diastolic away flow due to AR was observed in both cases. In conclusion, PDE is useful and non-invasive method for the diagnosis of conal VSD with AR.
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PMID:[A study of aortic regurgitation with conal ventricular septal defect by means of pulsed Doppler echocardiography]. 621 96