Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Neuromyelitis optica spectrum disorder (NMOSD) has a wide disease spectrum and sometimes shows abnormal eye movement with brainstem manifestations. However, bilateral oculomotor nerve palsy with a midbrain lesion has never been reported in a patient with NMOSD. We describe a 61-year-old woman with progressive ptosis and diplopia. She displayed bilateral oculomotor nerve palsy and hypersomnia. Brain MRI demonstrated abnormal signal intensities in the midbrain and around the third ventricle and hypothalamus with a mild contrast enhancement. A cerebrospinal fluid study indicated elevated protein and pleocytosis. Because serum anti-aquaporin-4 IgG antibody was positive, the patient was diagnosed with neuromyelitis optica spectrum disorder with aquaporin-4 IgG. We report for the first time bilateral oculomotor nerve palsy as an initial manifestation in a patient with aquaporin-4 positive NMOSD.
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PMID:Bilateral oculomotor nerve palsy in a case of anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder. 3117 6

A 60-year-old man presented with no light perception, ptosis and ophthalmoplegia in the right eye. The right fundus examination showed marked optic disc swelling. Serological tests for infectious and infiltrative diseases were all negative. Serum aquaporin-4 antibodies were negative, but anti-myelin oligodendrocyte glycoprotein (MOG) antibodies were positive. Magnetic resonance imaging revealed an extensive lesion in the right optic nerve with abnormal enhancement in the right orbital apex. His vision and eye movements improved after corticosteroid therapy. This report attests to the wide clinical phenotype possible in anti-MOG disease, including orbital apex syndrome.
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PMID:Case Report: Anti-myelin Oligodendrocyte Glycoprotein (MOG) Positive in a Patient Presented with Orbital Apex Syndrome. 3301 11