Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recurrent systemic envenomation in patients who sustained viper bites, and who previously responded to antivenom, is well described in the literature. However, cases of recurrent neurotoxic envenoming after antivenom treatment are rarely reported. We present three patients who were envenomed by a cobra (Naja kaouthia or N. siamensis) and experienced recurrent neurotoxic envenomation after they initially responded to antivenom treatments. These three patients, aged 13, 35 and 65 years, were consulted to the Ramathibodi Poison Centre. All were bitten by cobra snakes and developed neurotoxic signs and symptoms including ptosis, muscle weakness, and respiratory failure. All were treated with, and responded to, Fragment Affinity-Purified Secondary Antibody [F(ab')2] antivenom. Two cases underwent debridement and fasciotomy. One case required extensive wound dressing with bleb aspiration, in addition to usual wound care. Approximately 6-14 hours after these procedures, all three patients developed recurrent signs and symptoms of neurotoxicity. All received second doses of antivenom, after which their symptoms improved, and all were ultimately discharged. Each of these cases exhibited recurrent systemic envenomation that resulted from cobra bites after they exhibited antivenom responses. We believe that non-neutralized venom that remained at the bite site, was released, and re-entered the circulation after the wound was manipulated or the patient underwent surgery. This may explain these instances of recurrent envenomation. Future investigations should examine other potential mechanisms of recurrent envenomation, especially in patients without histories of aggressive wound manipulation. If neurological effects recur, prompt re-treatment with antivenom should be considered.
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PMID:Recurrent neurotoxic envenoming of cobra bite. 3112 62

OBJECTIVE Pelvic organ prolapse (POP) is a very frequent situation in our population that may lead to a significant decrease in patients' quality of life. Currently, we are looking for predictive factors for the development of POPs; thus, this study seeks to evaluate whether the Fibulin 5 polymorphism (FBLN5) is associated with the occurrence of POP. METHODS This is a cohort study with postmenopausal women who were divided into groups by POP stage: POP stages 0 and I (control group) and POP stages III and IV (case group). Subsequently, analyses of genetic polymorphisms of FBLN5 were performed using the Restriction Fragment Length Polymorphism (RFLP) technique. RESULTS A total of 292 women were included in the study. Pregnancy, parity and vaginal delivery in the patients, as well as in data described in the literature, were related to the occurrence of POP in the univariate analysis. However, after binary logistic regression, home birth and age remained independent risk factors for POP. We found no association between the FBLN5 polymorphism and the occurrence of POP (p = 0.371). CONCLUSION There was no association between the FBLN5 polymorphism and the occurrence of POP in Brazilian women.
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PMID:Evaluation of the fibulin 5 gene polymorphism as a factor related to the occurrence of pelvic organ prolapse. 3263 75