Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0033377 (prolapse)
 11,717 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Estrogens, whether natural or synthetic, have a wide range of clinical uses in the human female. In prepubertal females, estrogens are used in treating gonadal dysgenesis, excessive height, and genital infections. During the reproductive years, estrogens are used in managing 1) menstrual disorders (amenorrhea, menorrhagia, dysmenorrhea); 2) infertility (poor cervical mucus and anovulation); 3) pregnancy (abortion, lactation suppression); 4) dermatological disorders (acne vulgaris, hirsutism); 5) combined estrogen/progestogen usage for contraception; and 6) postcoital contraception. During the climacteric/postmenopausal years, estrogens are used in treating menopausal syndrome and breast cancer as well as various genital problems (infection, atropic vaginitis, genital prolapse). In the human male, estrogens are used in treating prostatic carcinoma and sexual problems. Estrogen therapy should be used with caution, and benefits should be weighed against the hazards. Possible side effects and alternative forms of treatment should be considered.
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PMID:Clinical uses of estrogens. 700 4

This study determines whether or not fibrin deposits occur more frequently in patients who had gynecologic surgical procedures for prolapse of uterus and treated with estrogens than in those in a control group. 11 women were given 50 ug of ethinyl estradiol daily for 3 weeks while 8 women were given 200 ug ethinyl estradiol daily for 12 days. The remaining 157 women who received no hormonal treatment served as controls. The women were examined postoperatively by the Iodine fibrinogen uptake test and phlebography according to the method of Nylander. The chi-square test with Yate's correction was used for data analysis. Fibrin deposits were found in 6 of the 11 women who received 50 ug ethinyl estradiol for 3 weeks and in 4 of 8 women receiving 200 ug for 12 days. Corresponding figures for the control group were 18 of 157, p 0.001. Estrogens should not prescribed to patients preoperatively. Estrogen therapy should be discontinued in patients who are about to be operated.
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PMID:Estrogens and postoperative thrombosis evaluated by the radioactive iodine method. 740 6

Estrogens are crucial for the proper functioning of genitourinary tract. Hypoestrogenism related to menopause could be linked to numerous disturbances of lower urinary tract. However, the results of most well designed clinical studies do not support use of estrogen or hormone replacement therapy for the treatment of genitourinary symptoms. According to evidence base medicine stress urinary incontinence, overactive bladder syndrome or pelvic organ prolapse are best treated by the surgery or non-hormonal drug therapy.
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PMID:The controversies regarding the role of estrogens in urogynecology. 1829 24